Load-to-strength ratio at the radius is higher in adolescent and young adult females with obesity compared to normal-weight controls

Singhal, Vibha; Huynh, Carolyn; Nimmala, Supritha; Mitchell, Deborah M.; Pedreira, Clarissa Carvalho; Bader, Abeer; Flanders, Karen; Zheng, Jane; Bouxsein, Mary L.; Misra, Madhusmita; Bredella, Miriam A.

doi:10.1016/j.bone.2022.116515

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…Abdominal fat, as measured by WC, is a known risk factor for metabolic syndrome, type 2 diabetes, and cardiovascular disease, which may be due to adipose gene expression of the effector genes [ 53 ], its proximity to vital organs and its role in producing inflammatory adipokines [ 54 , 55 ]. However, incorporating the weight component could enhance the predictive power by indicating the overall load on the body, including the strain on bones, joints, and organs [ 56 , 57 ]. Furthermore, the integrated approach of WWI better reflects the adiposity-related biochemical stress on the body.…”

Section: Discussionmentioning

confidence: 99%

The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES

Guo,

Qing,

Chen

et al. 2024

Eat Weight Disord

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Background Amidst growing evidence of the intricate link between physical and mental health, this study aims to dissect the relationship between the waist-to-weight index (WWI) and suicidal ideation within a representative sample of the US population, proposing WWI as a novel metric for suicide risk assessment. Methods The study engaged a sample of 9500 participants in a cross-sectional design. It employed multivariate logistic and linear regression analyses to probe the association between WWI and suicidal ideation. It further examined potential nonlinear dynamics using a weighted generalized additive model alongside stratified analyses to test the relationship's consistency across diverse demographic and health variables. Results Our analysis revealed a significant positive correlation between increased WWI and heightened suicidal ideation, characterized by a nonlinear relationship that persisted in the adjusted model. Subgroup analysis sustained the association's uniformity across varied population segments. Conclusions The study elucidates WWI's effectiveness as a predictive tool for suicidal ideation, underscoring its relevance in mental health evaluations. By highlighting the predictive value of WWI, our findings advocate for the integration of body composition considerations into mental health risk assessments, thereby broadening the scope of suicide prevention strategies.

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Section: Discussionmentioning

confidence: 99%

The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES

Guo,

Qing,

Chen

et al. 2024

Eat Weight Disord

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“…Previous studies have reported that these factors affect bone health during adolescence (50,51). In addition, this study investigated the association between obesity status and BMD, which, although most important for bone health, does not 100% represent bone health, as Longhi et al and Vibha et al both found an increased risk of bone fractures in the extremities of adolescents with excess obesity compared with average weight, which may be related to reduced bone strength due to reduced cross-sectional and cortical areas of the skeleton (27,52).…”

Section: Discussionmentioning

confidence: 99%

Effect of obesity status on adolescent bone mineral density and saturation effect: A cross-sectional study

Wang

Fang²,

Li³

et al. 2022

Front. Endocrinol.

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BackgroundThe effect of obesity status on bone mineral density (BMD) in adolescents and whether there is a saturation effect is still insufficient. A cross-sectional study of adolescents aged 12–19 was conducted to investigate them.MethodsWeighted multivariate linear regression models were used to assess the relationship between obesity status and BMD via datasets from the National Health and Nutrition Examination Survey 2011–2018. The nonlinear relationships and saturation values were ascertained by fitting smooth curves and analyzing saturation effects. At the same time, the subgroup stratified analysis was also performed.Results4056 adolescents were included in this study. We found that body mass index (BMI) and waist circumference (WC) were significantly associated with total BMD, which remained significant in subgroups stratified by age, gender, standing height, and ethnicity. We also noticed an inverse correlation between left leg fat/lean mass and left leg BMD, which was only significant in males and other races. Fitting smooth curve and saturation effect analysis showed that BMI, WC, left leg fat/lean mass, and BMD had a specific saturation effect. There was a saturation effect on bone mineral density in adolescents with a BMI of 22 kg/m2, a WC of 70.5 cm, or a left leg fat/lean mass of 0.2994.ConclusionsWe found a positive saturation effect of BMI and WC with BMD and a negative saturation effect of left leg fat/lean mass with BMD. Appropriate obesity status allows adolescents to have better bone mass development but not excessive obesity.

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“…µFEA was used to assess strength estimates (stiffness and failure load) and elastic modulus using published methods [ 3 , 24 ]. The load-to-strength ratio (factor of risk) at the distal radius was calculated to assess the risk of fracture at the distal forearm by relating applied force of fall to bone strength [ 25 ]. A higher load-to-strength ratio is consistent with greater risk of fracture.…”

Section: Methodsmentioning

confidence: 99%

Bone Density, Geometry, Structure and Strength Estimates in Adolescent and Young Adult Women with Atypical Anorexia Nervosa versus Typical Anorexia Nervosa and Normal-Weight Healthy Controls

Tuli,

Singhal,

Slattery

et al. 2023

Nutrients

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Our objective was to characterize bone outcomes in adolescent and young adult women with atypical anorexia nervosa (AAN) compared to typical AN and normal-weight healthy controls (HC) based on DSM-5 criteria. Four hundred thirty-two participants (141 AN, 131 AAN and 160 HC), ages 12–21 years, underwent dual-energy X-ray absorptiometry for areal BMD, and a subset had high-resolution peripheral quantitative CT assessment of the distal radius and tibia for volumetric BMD (vBMD), bone geometry and microarchitecture, and microfinite element analysis for estimated strength. The groups did not differ for age, pubertal stage, menarcheal age or physical activity. BMI and bone outcomes overall were intermediate in AAN compared with AN and HC. This applied to spine, total hip and femoral neck BMD measures and many distal tibial measures. However, the mean whole-body less head BMD Z-score did not differ between AAN and AN, and it was lower in both vs. HC. Similarly, many distal radius measures did not differ between AAN vs. AN or HC but were lower in AN than HC. Lower BMI, lean mass and bone age, older menarcheal age and longer illness duration correlated with greater impairment of bone outcomes. These data indicate that individuals with AAN overall have bone outcomes that are intermediate between AN and HC.

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Load-to-strength ratio at the radius is higher in adolescent and young adult females with obesity compared to normal-weight controls

Cited by 10 publications

References 34 publications

The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES

The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES

Effect of obesity status on adolescent bone mineral density and saturation effect: A cross-sectional study

Bone Density, Geometry, Structure and Strength Estimates in Adolescent and Young Adult Women with Atypical Anorexia Nervosa versus Typical Anorexia Nervosa and Normal-Weight Healthy Controls

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