SummaryBilateral external fixator frames are frequently preferred over unilateral frames due to their superior rigidity. The objective of this study was to compare the biomechanical features of bilateral external fixators with those of unilateral external fixators that are combined with an intra-medullary pin. Three-dimensional, solid models were created of several unilateral and bilateral external fixator frames. The callus in the fracture gap was also modeled. Biomechanical analyses of all constructs were performed by the finite element method. This modeling approach allows the determination of stresses, displacements, and strains in the components of the various constructs, and thus the calculation of their relative stiffness. In addition, local shear strain values in the fracture gap, currently thought to be one of the deciding factors in the process of bone healing, can also be determined. The concept of equivalent stiffness modulus, which represents a weighed average stiffness of a construct to various loads, was defined. Using this concept, it was shown that when the intramedullary pin is well seated in the epiphyseal bone, the various unilateral frames have an equivalent stiffness modulus that is similar or even greater than that of bilateral frames with a similar arrangement of transcortical pins.