Loading and relaxation dynamics of a red blood cell

Guglietta, Fabio; Behr, Marek; Falcucci, Giacomo; Sbragaglia, Mauro

doi:10.1039/d1sm00246e

Cited by 17 publications

(18 citation statements)

References 62 publications

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“…Liu et al [61] developed a coupled IBM-LBM with an absolute nodal coordinate formula and acceleration techniques to simulate large deformation in complex multiple flexible immersed structures. Guglietta et al [62,63] coupled the IB-LBM with the standard linear solid model to account for the red blood cell membrane viscosity. As for the rigid moving boundaries, researchers used various approaches to spread the IB force over fluid nodes by means of the Dirac delta function.…”

Section: Numerical Methods For Particle-fluid Hydrodynamicsmentioning

confidence: 99%

A Review on Contact and Collision Methods for Multi-Body Hydrodynamic Problems in Complex Flows

Karimnejad¹,

Delouei²,

Başağaoğlu³

et al. 2022

CICP

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Modeling and direct numerical simulation of particle-laden flows have a tremendous variety of applications in science and engineering across a vast spectrum of scales from pollution dispersion in the atmosphere, to fluidization in the combustion process, to aerosol deposition in spray medication, along with many others. Due to their strongly nonlinear and multiscale nature, the above complex phenomena still raise a very steep challenge to the most computational methods. In this review, we provide comprehensive coverage of multibody hydrodynamic (MBH) problems focusing on particulate suspensions in complex fluidic systems that have been simulated using hybrid Eulerian-Lagrangian particulate flow models. Among these hybrid models, the Immersed Boundary-Lattice Boltzmann Method (IB-LBM) provides mathematically simple and computationally-efficient algorithms for solid-fluid hydrodynamic interactions in MBH simulations. This paper elaborates on the mathematical framework, applicability, and limitations of various 'simple to complex' representations of close-contact interparticle interactions and collision methods, including short-range interparticle and particle-wall steric interactions, spring and lubrication forces, normal and oblique collisions, and mesoscale molecular models for deformable particle collisions based on hard-sphere and soft-sphere models in MBH models to simulate settling or flow of nonuniform particles of different geometric shapes and sizes in diverse fluidic systems.

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Section: Numerical Methods For Particle-fluid Hydrodynamicsmentioning

confidence: 99%

A Review on Contact and Collision Methods for Multi-Body Hydrodynamic Problems in Complex Flows

Karimnejad¹,

Delouei²,

Başağaoğlu³

et al. 2022

CICP

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“…In particular, Barthès-Biesel (2016) considered a capsule with membrane viscosity under simple shear flow, and they observed that the response (loading) time made dimensionless via the intrinsic time decreases with the capillary number. Moreover, Guglietta et al (2020Guglietta et al ( , 2021b studied the transient dynamics of RBCs under simple shear flow and in order to compare their numerical results against experiments, they reported the characteristic loading and relaxation times (in [s] on the y-axis) as functions of the shear rate γ (in [s −1 ] on the x-axis). We therefore decided to take this as an example, and to normalise both x-and y-axis with the capillary time t * , thus obtaining the dimensionless loading time t L as a function of the capillary number Ca.…”

Section: Simulation Set-up and Physical Parametersmentioning

confidence: 99%

“…The mechanical and rheological properties of suspensions of purely elastic capsules have been thoroughly studied analytically (Barthès-Biesel & Rallison 1981;Barthès-Biesel 1980, 1991, 1993Barthès-Biesel, Diaz & Dhenin 2002), experimentally (Chang & Olbricht 1993;Walter, Rehage & Leonhard 2001) and numerically (Pozrikidis 1995;Ramanujan & Pozrikidis 1998;Diaz, Pelekasis & Barthès-Biesel 2000;Dodson & Dimitrakopoulos 2009;Clausen & Aidun 2010;Bagchi & Kalluri 2011;Clausen, Reasor & Aidun 2011;Krüger, Varnik & Raabe 2011;Pranay, Henríquez-Rivera & Graham 2012;Cordasco & Bagchi 2013;Karyappa, Deshmukh & Thaokar 2014;Krüger, Kaoui & Harting 2014;Rorai et al 2015;Alizad Banaei et al 2017;Kessler, Finken & Seifert 2008;Tran et al 2020;Wouters et al 2020;Aouane, Scagliarini & Harting 2021;Bielinski et al 2021;Esposito et al 2022). However, only a few studies were dedicated to understanding the effect of the capsules' membrane viscosity (Barthès-Biesel & Sgaier 1985;Diaz, Barthès-Biesel & Pelekasis 2001;Yazdani & Bagchi 2013;Li & Zhang 2019;Guglietta et al 2020Guglietta et al , 2021aZhang et al 2020;Guglietta et al 2021b;…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Li & Zhang (2019 coupled a finite difference method with the immersed boundary-lattice Boltzmann (IB-LB) method to simulate the effect of the viscosity at the interface. This implementation has been then employed to investigate mainly the dynamics of RBCs, highlighting the key role played by the membrane viscosity on the deformation and the associated characteristic times (Guglietta et al 2020(Guglietta et al , 2021bLi & Zhang 2021) as well as on the tumbling and tank-treading dynamics (Guglietta et al 2021a;.…”

Section: Introductionmentioning

confidence: 99%

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Suspensions of viscoelastic capsules: effect of membrane viscosity on transient dynamics

Guglietta,

Pelusi,

Sega

et al. 2023

J. Fluid Mech.

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Membrane viscosity is known to play a central role in the transient dynamics of isolated viscoelastic capsules by decreasing their deformation, inducing shape oscillations and reducing the loading time, that is, the time required to reach the steady-state deformation. However, for dense suspensions of capsules, our understanding of the influence of the membrane viscosity is minimal. In this work, we perform a systematic numerical investigation based on coupled immersed boundary–lattice Boltzmann (IB-LB) simulations of viscoelastic spherical capsule suspensions in the non-inertial regime. We show the effect of the membrane viscosity on the transient dynamics as a function of volume fraction and capillary number. Our results indicate that the influence of membrane viscosity on both deformation and loading time strongly depends on the volume fraction in a non-trivial manner: dense suspensions with large surface viscosity are more resistant to deformation but attain loading times that are characteristic of capsules with no surface viscosity, thus opening the possibility to obtain richer combinations of mechanical features.

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“…32 Guglietta et al performed a detailed comparison of loading and unloading dynamics with three different typologies of load, namely stretch, shear, and elongational flow, while changing the membrane viscosity of the cell. 33 They concluded that the time asymmetry of loading and unloading processes is profound in shear flows and increases on higher load strengths.…”

mentioning

confidence: 99%

Dynamic response of red blood cells in health and disease

Hareendranath

Sathian

2023

Soft Matter

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Loading and relaxation dynamics of a red blood cell

Abstract: We use mesoscale numerical simulations to investigate the unsteady dynamics of a single red blood cell (RBC) subjected to an external mechanical load. We carry out a detailed comparison between...

Cited by 17 publications

References 62 publications

A Review on Contact and Collision Methods for Multi-Body Hydrodynamic Problems in Complex Flows

A Review on Contact and Collision Methods for Multi-Body Hydrodynamic Problems in Complex Flows

Suspensions of viscoelastic capsules: effect of membrane viscosity on transient dynamics

Dynamic response of red blood cells in health and disease

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