Loading and release of doxorubicin hydrochloride from iron(iii) trimesate MOF and zinc oxide nanoparticle composites

Abstract

The porosity of iron(iii) trimesate and the presence of nanoparticles significantly affect the loading and release of doxorubicin.

An overview of the development of composites containing Mg and Zn for drug delivery

“…It was reported that the prepared bio-nanocomposite could be used for anticancer drug delivery. Bhattacharjee et al [175] successfully incorporated ZnO into Fe (III) trimesate metal-organic framework (MIL-100(Fe)) to deliver anticancer drugs of doxorubicin hydrochloride (DOX) by the one-pot in-situ method. The investigation rendered interesting insights into the incorporation of NPs into MIL-100(Fe) and its drug loading capacity as well as release rates.…”

Biocompatible Drug Delivery System Based on a MOF Platform for a Sustained and Controlled Release of the Poorly Soluble Drug Norfloxacin

“…Drug delivery systems that comprise metal–organic frameworks (MOFs) as carriers or vehicles have proven to be attractive over the years and several researchers have reported cases with a focus on drug loading and delivery. − It is equally interesting to realize that MOFs are excellent platforms for a sustained and controlled release of drug molecules, and the property is potentially demanding for those drugs in the pharmaceutical industry that face major formulation-related problems of low water solubility, , thus leading to the decreased bioavailability of active pharmaceutical ingredients (APIs). It is not surprising that the focus has shifted to the latter with new investigations, if not too many, emerging on the sustained and controlled release of drugs from MOF-based drug delivery systems (DDSs). − …”

“…MOFs are hybrid crystalline materials that consist of cationic metal nodes and anionic/neutral organic linkers connected via coordination bonds expanding in three dimensions. − The high pore volume and surface area of MOFs have attracted researchers from all over the world, enabling their use in various applications, namely, gas storage, , catalysis, , dye adsorption, drug delivery, − ,− etc. Many MOFs possess a variety of biological applications aided by (i) biocompatibility, biodegradability, and nontoxicity; (ii) facile surface chemistry that allows conjugation of various functionalities; (iii) the ability to load a variety of cargos; ,− (iv) stability within the gastrointestinal tract; etc .…”

“…Therefore the search for a DDS that shows an effective and efficient release of NFX in a sustained and controlled manner and is easily processable is highly desirable. Although several drugs have been loaded on various MOFs, − ,− norfloxacin loading and its release from MOFs have not been studied and reported to date. During our experiments in the laboratory, we have observed that norfloxacin is a notorious drug molecule, as it rapidly precipitates out in aqueous media even at very low concentrations (0.40 mg mL –1 at pH 7 and 0.45 mg mL –1 at pH 7.5).…”

GCMC simulations to study the potential of MOFs as drug delivery vehicles

“…Studies have reported the use of MOFs in combination with chemotherapy drugs, doxorubicin, paclitaxel, etc., for the treatment of lung cancer, which proves the MOF-loaded drug system for doxorubicin and paclitaxel to be significantly effective. [20][21][22][23][24] Researchers are also trying to surface-modify MOFs in order to increase their absorption and drug-loading efficiency, improve the stability of MOFs' oral drug delivery systems, and regulate the compatibility between MOFs and biological systems. 25 Computer simulation technology refers to a technical method that dynamically simulates or re-enacts the UiO-66-NDC 0.7 400-500 14 behavior of a complex system on a digital computer so as to obtain quantitative indicators of the characteristics of the system and provide a basis for the decision-making process, 26 which is not limited by experimental conditions, time, and space and has great flexibility and arbitrariness.…”