Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

Aroni, Mauricio Andrés Tinajero; Oliveira, Guilherme José Pimentel Lopes de; Spolidório, Luís Carlos; Andersen, Ole; Foss, Morten; Marcantonio, Rosemary Adriana Chiérici; Stavropoulos, Andreas

doi:10.1007/s00784-018-2588-6

Cited by 18 publications

(15 citation statements)

References 43 publications

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“…Aroni et al functionalized with Sr ions the surface of deproteinized bovine bone (Sr-DBB) to be used as implantable material for calvarial critical size defect in rats (5 mm in diameter), with two different doses of Sr loaded onto DBB particles: 19.6 μg/g and 98.1 μg/g. For both concentrations of Sr a fewer number of inflammatory cells in the bone defect site was observed and a higher amount of new bone formation was detected at 60 days when compared to Sr-free counterpart [ 115 ]. Also Elgali et al functionalized a deproteinized bovine bone (DBB) with SrHA powders with three levels of Ca substitution by Sr: 5% (SrHA005), 25% (SrHA025) and 50% (SrHA050).…”

Section: Biomaterials For Bone Tissue Engineering Approach and Their ...mentioning

confidence: 99%

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

et al. 2022

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Strontium (Sr) is a trace element taken with nutrition and found in bone in close connection to native hydroxyapatite. Sr is involved in a dual mechanism of coupling the stimulation of bone formation with the inhibition of bone resorption, as reported in the literature. Interest in studying Sr has increased in the last decades due to the development of strontium ranelate (SrRan), an orally active agent acting as an anti-osteoporosis drug. However, the use of SrRan was subjected to some limitations starting from 2014 due to its negative side effects on the cardiac safety of patients. In this scenario, an interesting perspective for the administration of Sr is the introduction of Sr ions in biomaterials for bone tissue engineering (BTE) applications. This strategy has attracted attention thanks to its positive effects on bone formation, alongside the reduction of osteoclast activity, proven by in vitro and in vivo studies. The purpose of this review is to go through the classes of biomaterials most commonly used in BTE and functionalized with Sr, i.e., calcium phosphate ceramics, bioactive glasses, metal-based materials, and polymers. The works discussed in this review were selected as representative for each type of the above-mentioned categories, and the biological evaluation in vitro and/or in vivo was the main criterion for selection. The encouraging results collected from the in vitro and in vivo biological evaluations are outlined to highlight the potential applications of materials’ functionalization with Sr as an osteopromoting dopant in BTE.

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Section: Biomaterials For Bone Tissue Engineering Approach and Their ...mentioning

confidence: 99%

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

et al. 2022

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“…One paper was not analyzed in the further steps of the review because it was in Japanese and there were no resources that allowed proper translation, 122 one paper was retracted 123 and three papers were excluded because they used non-synthetic CaPs. [124][125][126] In the meta-analysis, 45 papers with 133 quantitative bone formation comparisons and 20 studies with 57 quantitative remaining material comparisons could be included.…”

Section: Paper Identification and Selectionmentioning

confidence: 99%

Bioinorganic supplementation of calcium phosphate-based bone substitutes to improvein vivoperformance: a systematic review and meta-analysis of animal studies

Lodoso‐Torrecilla

Gunnewiek²,

Grosfeld

et al. 2020

Biomater. Sci.

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“…Sr was also found to possess inherent antimicrobial potential, in vitro, when incorporated in the formulation of bioglass [29,30]. Furthermore, Sr was shown to promote osseointegration of Ti implants and to have a positive effect on bone regeneration [31][32][33]. Sr has also been used as a treatment for osteoporosis, acting by inhibiting osteoclast activity and accelerating osteoblast proliferation [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Properties of Strontium Functionalized Titanium Surfaces for Oral Applications, A Systematic Review

et al. 2021

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The aim of this systematic review was to assess the current scientific evidence of the antimicrobial potential of strontium (Sr) when used to functionalize titanium (Ti) for oral applications. Out of an initial list of 1081 potentially relevant publications identified in three electronic databases (MEDLINE via PubMed, Scopus, and Cochrane) up to 1 February 2021, nine publications based on in vitro studies met the inclusion criteria. The antimicrobial potential of Sr was investigated on different types of functionalized Ti substrates, employing different application methods. Nine studies reported on the early, i.e., 6–24 h, and two studies on the late, i.e., 7–28 days, antimicrobial effect of Sr, primarily against Staphylococcus aureus (S. aureus) and/or Escherichia coli (E. coli). Sr-modified samples demonstrated relevant early antimicrobial potential against S. aureus in three studies; only one of which presented statistical significance values, while the other two presented only the percentage of antimicrobial rate and biofilm inhibition. A relevant late biofilm inhibition potential against S. aureus of 40% and 10%—after 7 and 14 days, respectively—was reported in one study. Combining Sr with other metal ions, i.e., silver (Ag), zinc (Zn), and fluorine (F), demonstrated a significant antimicrobial effect and biofilm inhibition against both S. aureus and E. coli. Sr ion release within the first 24 h was generally low, i.e., below 50 µg/L and 0.6 ppm; however, sustained Sr ion release for up to 30 days, while maintaining up to 90% of its original content, was also demonstrated. Thus, in most studies included herein, Sr-functionalized Ti showed a limited immediate (i.e., 24 h) antimicrobial effect, likely due to a low Sr ion release; however, with an adequate Sr ion release, a relevant antimicrobial effect, as well as a biofilm inhibition potential against S. aureus—but not E. coli—was observed at both early and late timepoints. Future studies should assess the antimicrobial potential of Ti functionalized with Sr against multispecies biofilms associated with peri-implantitis.

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Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

Cited by 18 publications

References 43 publications

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

Bioinorganic supplementation of calcium phosphate-based bone substitutes to improvein vivoperformance: a systematic review and meta-analysis of animal studies

Antimicrobial Properties of Strontium Functionalized Titanium Surfaces for Oral Applications, A Systematic Review

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