Lobothallia radiosa:A New Record of Lichen Genus Lobothallia from China

Mamut, Reyim; Suo, Feiya; Abbas, Abdulla

doi:10.3724/sp.j.1142.2012.30305

Cited by 5 publications

(2 citation statements)

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“…(+)‐Usnic acid ( PS0 ) (Figure ) is a benzofurandione, phloroglucinol like, secondary metabolite from lichens (Figure ): some species growing in China accumulate usnic acid, a finding that makes the compounds of industrial interest when compared to other low occurring secondary metabolites and it is now commercially available.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimycobacterial activity of (+)‐usnic acid conjugates

Cirillo

Borroni

Festoso

et al. 2018

Archiv der Pharmazie

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New therapeutics are urgently needed to fight tuberculosis and mycobacteria-related diseases that are a major health hazard especially in poor countries. Natural products have been the source of important antitubercular drugs in the past and still need to receive attention as a potent reservoir of chemical structures. Fifteen known and two new (+)-usnic acid (a benzofurandione formerly isolated from lichens) enamines and hydrazones are here described and tested against sensitive and multidrug-resistant strains of mycobacteria. Among several (+)-usnic acid conjugates, PS14 and PS18 showed potent activity against both susceptible and resistant Mycobacterium tuberculosis strains (MIC values of 1-32 and 2-32 mg/L, respectively) comparable with MIC of other antitubercular drugs already in use for tuberculosis treatment.

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Section: Introductionmentioning

confidence: 99%

Synthesis and antimycobacterial activity of (+)‐usnic acid conjugates

Cirillo

Borroni

Festoso

et al. 2018

Archiv der Pharmazie

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“…highest isolated yield of 26%. [112] It occurs in nature as both (-) and (+) isomers as well as a racemic mixture and is one of the few lichen secondary metabolites that are commercially available. UA has been of interest to chemist and pharmacologists owing to the broad range of its biological activity, such as antitumor, antiviral, antimicrobial, anti-inflammatory, and insecticidal effects.…”

Section: Cytotoxic Activity Against Other Four Cancer Cell Linesmentioning

confidence: 99%

Bioactive compounds from lichen usnea aciculifera vain and usnic acid conjugates

Lam

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Phytochemical investigation of lichen Usnea aciculifera Vain led to the isolation of nine new dimeric xanthones, usneaxanthones A-I (3644), along with 36 known compounds (135, 45). The chemical structures of the isolated compounds were elucidated by a combination spectroscopic data (1D, 2D NMR, HRESIMS), ECD�experiments, and single-crystal X-ray�as well as comparison of their NMR data with those in the literature. The biological activities of isolated compounds were evaluated for antibacterial, anti-dengue and cytotoxic activites. The results revealed that depsides may have potential as lead compounds for the development of new antibacterial and anti-dengue agents. Futhermore, dimeric xanthones exhibited highly potent cytotoxicity against HT-29, HCT116, MCF-7 and A549 cancer cell lines with IC50 values ranging from 2.41 to 9.86 ?M. Among isolated compounds, usnic acid was obtained as a major compound. Twenty-five usnic acid derivatives (UA01UA25) were synthesized and evaluated on ?-glucosidase activity. UA02, UA06, UA08, UA11UA14, UA16UA17 and UA24UA25 were identified as new semisynthetic compounds. For ?-glucosidase activity, UA01, UA03UA04, UA06, UA11UA13 and UA17UA18 exhibited potential activity with IC50 from 14.5199.04 ?M compared with acarbose (IC50 93.6 ?M) as a positive control.

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