Lobular carcinoma in situ with microinvasion

Nemoto, Takuma; Castillo, Nieva; Tsukada, Yoshiaki; Koul, Ashok Raj; Eckhert, Kenneth H.; Bauer, Ronald

doi:10.1002/(sici)1096-9098(199801)67:1<41::aid-jso9>3.0.co;2-m

Cited by 27 publications

(13 citation statements)

References 10 publications

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“…Although microinvasion is virtually almost exclusively associated with high nuclear grade-comedo ductal carcinoma in situ (DCIS), it may also be associated with other types of DCIS and with LCIS [6] (Figs. 1 and 2).…”

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confidence: 99%

Microinvasive Carcinoma of the Breast

Bianchi

Vezzosi

2008

Pathol. Oncol. Res.

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The increased rate of early detection of breast cancer due to widespread mammographic screening has led to an increased incidence not only of in situ but also microinvasive carcinoma (MC). MC has been reported to have a favourable prognosis, but specific definitions have varied in the past making the clinical significance of this entity a subject of debate. In fact, although the diagnosis of MC often appears in pathology reports, this term has not been used in a consistent, standardized manner. In addition, the histological diagnosis of MC can be problematical for the pathologist due to a variety of in situ patterns and artefacts that may be misinterpreted as stromal invasion. Definitions and diagnostic criteria of MC are reviewed and discussed. Based on a review of literature, incidence of axillary lymph node involvement, according to different definitions of microinvasion, is reported.

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Section: Abbreviationsmentioning

confidence: 99%

Microinvasive Carcinoma of the Breast

Bianchi

Vezzosi

2008

Pathol. Oncol. Res.

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“…MIBC is frequently found in a high nuclear gradecomedo ductal carcinoma in situ (DCIS) setting, less frequently with other types of DCIS or lobular carcinoma in situ (LCIS) [4]. The sole presence of an invasive breast carcinoma 1 mm or less, without any in situ background, is very rare and should be better regarded as an invasive carcinoma of that specific diameter [5].…”

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confidence: 99%

Microinvasive breast cancer: pathological parameters, cancer subtypes distribution, and correlation with axillary lymph nodes invasion. Results of a large single-institution series

et al. 2015

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“…Not only do both pleomorphic lobular carcinoma in situ and lobular carcinoma in situ with necrosis show different morphology, they can also exhibit a more aggressive biologic marker profile compared to classic lobular carcinoma in situ. 6,[8][9][10][11][12] Microinvasive lobular carcinoma has been associated with pleomorphic lobular carcinoma in situ or lobular carcinoma in situ with necrosis, 6,8,9,13 although in routine practice, microinvasive carcinomas have also been observed in association with classic lobular carcinoma in situ. Lobular carcinoma in situ with nonclassic features has also been found to be more frequently associated with adjacent invasive carcinoma, especially invasive lobular carcinoma.…”

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confidence: 99%

Atypical lobular hyperplasia and classic lobular carcinoma in situ in core biopsy specimens: routine excision is not necessary

Hwang

Barke

Mendelson³

et al. 2008

Modern Pathology

104

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Standardized recommendations for the management of lobular neoplasia in core biopsy specimens are not established. The aim of our study was to define morphologic features of lobular neoplasia in core biopsies that predict the finding of ductal carcinoma in situ or invasive carcinoma in the subsequent excisional specimen. We reviewed 333 cases of atypical lobular hyperplasia or lobular carcinoma in situ without ductal carcinoma in situ or invasive carcinoma diagnosed in core biopsies from 1996 to 2006. Subsequent excision was performed in 41% (136/333) of cases, including atypical lobular hyperplasia (n ¼ 48), lobular carcinoma in situ (n ¼ 39), and lobular neoplasia associated with atypical ductal hyperplasia (n ¼ 49). Upgrades were identified in 2% (1/48) of atypical lobular hyperplasia, 23% (9/39) of lobular carcinoma in situ, and 27% (13/49) of lobular neoplasia associated with atypical ductal hyperplasia cases. When further analyzed, the upgraded cases of lobular carcinoma in situ were associated with radiologic-pathologic discordance in 6/9 cases and with nonclassic pathology (two lobular carcinoma in situ with necrosis and one pleomorphic lobular carcinoma in situ) in the remaining three cases. The frequency of upgrade was 11% (3/26) in classic lobular carcinoma in situ, and 46% (6/13) in nonclassic types (pleomorphic or with necrosis). After excluding cases with discordant imaging/ pathology, there was a 5% upgrade in our excisional specimens. After excluding cases where the upgrade was associated with nonclassic morphology, the upgrade in our study was 1%. Our results suggest that atypical lobular hyperplasia and classic lobular carcinoma in situ with concordant radiology and pathology can be appropriately managed with clinical follow-up without surgery.

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Lobular carcinoma in situ with microinvasion

Cited by 27 publications

References 10 publications

Microinvasive Carcinoma of the Breast

Microinvasive Carcinoma of the Breast

Microinvasive breast cancer: pathological parameters, cancer subtypes distribution, and correlation with axillary lymph nodes invasion. Results of a large single-institution series

Atypical lobular hyperplasia and classic lobular carcinoma in situ in core biopsy specimens: routine excision is not necessary

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