By the end of World War II and in the shadow of the Cold War, many Asia-Pacific nations developed their psychiatric disciplines and strengthened their mental health care provision. This article examines the activities of the first generation of psychiatrists in Taiwan during the postwar period, focusing on their self-fashioning during the transition of a medical discipline. At this time, psychiatry was imagined by the state and by professionals as a science serving different clinical and political objectives. Psychiatrists, however, enjoyed a relatively unrestricted environment that allowed them to gradually form a professional identity. At the height of the Cold War, the state attempted to use psychiatry for political ends. Because of its initially malleable nature and undeveloped content, psychiatry could be employed by various authorities for diverse purposes, including patient care, scientific inquiry, psychological warfare, and even political probes to obtain crucial information. Nevertheless, psychiatrists sought to create spaces where they could develop their professional autonomy and prevent exploitation amid complicated political polemics.