Abstract:Low-dose morphine applied to the harvest graft site can reduce local pain, morphine use, and chronic donor site pain after cervical spine fusion surgery.
“…Studies have suggested a reduction in donor-site pain by using different operative techniques [20][21][22][23], reconstructing the iliac crest using various materials such as coralline hydroxyapatite [24], or calcium phosphate [25] or inserting resorbable mesh [26], or bioactive ceramic spacers [27]. Many recent studies have also suggested superior short and long-term outcomes from post-operative analgesic infusion to the donor-site [18,[28][29][30][31]. A recent Cochrane Review protocol has been established to analyze this data collectively [32].…”
The design of the study includes case series, technical note and review of the literature. Autogenous bone graft (autograft) harvest from the iliac crest remains the gold standard substrate for spinal fusion. Persistent donor-site pain is the most common cause of morbidity after autograft harvest, occurring in one-third of patients.
“…Studies have suggested a reduction in donor-site pain by using different operative techniques [20][21][22][23], reconstructing the iliac crest using various materials such as coralline hydroxyapatite [24], or calcium phosphate [25] or inserting resorbable mesh [26], or bioactive ceramic spacers [27]. Many recent studies have also suggested superior short and long-term outcomes from post-operative analgesic infusion to the donor-site [18,[28][29][30][31]. A recent Cochrane Review protocol has been established to analyze this data collectively [32].…”
The design of the study includes case series, technical note and review of the literature. Autogenous bone graft (autograft) harvest from the iliac crest remains the gold standard substrate for spinal fusion. Persistent donor-site pain is the most common cause of morbidity after autograft harvest, occurring in one-third of patients.
“…Die verbleibenden 17 Originalarbeiten wurden analysiert ( [36,38,39,40,41,42,43,44,45,46,47,50,51,52,53,55,56];…”
Section: Einfluss Der Studien Von Reubenunclassified
“…Macrae [18] zitierte in seiner Veröffentlichung "Chronisch postoperative Schmerzen" im British Journal of Anesthesia zwei gefälschte Arbeiten von Reuben et al [50,56]. Er schreibt: "Es gibt mehrere Arbeiten, die Vorteile der Regionalanästhesie zeigen, z.…”
Section: Analyse Von Beispielenunclassified
“…Er schreibt: "Es gibt mehrere Arbeiten, die Vorteile der Regionalanästhesie zeigen, z. B. nach Hysterektomie, Sectio caesarea, Knochenspanentnahme [56] und Thorakotomie. Allerdings gibt es auch Studien, die keine Vorteile belegen konnten.…”
In February 2009 a major case of scientific misconduct was discovered. The American pain researcher Dr. S. Reuben had published 21 papers over a period of 15 years that were found to be fraudulent. Suddenly many advances in postoperative pain therapy which had been assumed to be correct seemed questionable. In this review article the lessons which can be learnt from this case are described. This review also reveals that it is almost impossible for reviewers or readers of scientific journals to detect scientific fraud. However, several warning signs can be identified that might be useful when reading clinical papers. In retrospect many of these signs were detectable in Reuben's studies. Based on the fraudulent papers of Reuben it will be shown how and to what extent falsified results can affect other types of literature, such as practice guidelines, meta-analyses, review articles and oral presentations.
“…reduzieren [2]? Ist das plausibel, noch dazu, wenn Meta analysen, die ja einen kompletten Über blick über vergleichbare Studien geben, die Effektivität von Maßnahmen zur Be einflussung chronischer Schmerzen eher skeptisch beurteilen?…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.