Local allergic conjunctivitis: a phenotype of allergic conjunctivitis

Yamana, Y; Fukuda, Ken; Ko, Ryota; Uchio, Eiichi

doi:10.1007/s10792-019-01101-z

Cited by 35 publications

(39 citation statements)

References 26 publications

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“…Vitro testing of IgE antibodies and specific allergens are widely used [27]. Some scholars claim that the results of IgE of tears and IgE of serum are sometimes inconsistent, so the IgE positive rate of tears may be more meaningful for local allergic conjunctivitis [107].…”

Section: Opn Opn Expression Is Enhanced In 2 Diseasesmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.

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Section: Opn Opn Expression Is Enhanced In 2 Diseasesmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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“…A previous report using skin prick test or ImmunoCAP, wherein results were highly correlated with the current panel IgE test [15], revealed that the positivity of D. pteronyssinusand house dust-speci c IgE in patients with asthma was higher compared with patients with COPD [16,17]. Contrarily, the positivity for Candida (21.5%) and moth (35.4%) in this study was comparable to the reported positivity in asthma [16] and was not different between ACO and non-ACO COPD (Table 1).…”

Section: Discussionmentioning

confidence: 57%

Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

Toyota

Sugimoto

Kobayashi

et al. 2020

Preprint

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Background Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD pathology is unclear. This study aimed to identify the specific IgE related to clinical features of COPD and the diagnosis of asthma-COPD overlap (ACO). Methods We recruited 70 patients with COPD and analyzed 39 IgE using panel IgE test (View Allergy 39®). ACO was diagnosed according to the Japanese Respiratory Society Guidelines. Results As for perennial aeroallergens, the positivity for moth (35.4%), cockroach (23.1%), Dermatophagoides pteronyssinus (21.5%), house dust (21.5%), and Candida (21.5%) and, concerning pollen, Japanese cedar (36.9%) and Japanese cypress (23.1%) exceeded 20%. Only the positivity of IgE for Dermatophagoides pteronyssinus and house dust was significantly higher in ACO compared with that in non-ACO COPD. Moreover, it contributed to the diagnosis of ACO in an IgE class-dependent manner. Patients with cockroach IgE exhibited higher residual volume, whereas those with Japanese cedar IgE exhibited better diffusion capacity than negative patients. The contribution for ACO diagnosis by the receiver operating characteristic curve analysis was comparable among total IgE (cutoff value: 158 IU/mL), blood eosinophil count (234/µl), and fraction of exhaled nitric oxide (31.0 ppb). Conclusions The prominent role of mite-specific IgE in the diagnosis and pathology of ACO and the potentially detrimental effect of cockroach sensitization on air trapping in COPD were suggested. The finding highlights the future development of a treatment targeting IgE as a treatable trait in COPD.

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“…33 A recent Japanese study suggests the existence of an ocular counterpart of LAR in non-atopic patients with conjunctivitis and detectable total IgE in tears. 34 Unfortunately, the specificity of IgE in tears was not defined, since conjunctival allergen challenge was not performed. There is still a lack of knowledge on the nature of ocular symptoms as to whether there is a real sensitization in conjunctiva or whether the symptoms occur as a result of nasal-ocular reflexes due to allergen exposure.…”

Section: Lar and Conjunctivitismentioning

confidence: 99%

Local allergic rhinitis: a pediatric perspective

Beken¹,

Eguiluz‐Gracia²,

Yazıcıoğlu³

et al. 2020

Turk J Pediatr

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Local allergic rhinitis (LAR) is a differentiated rhinitis phenotype defined by perennial or seasonal rhinitis symptoms without systemic atopy. The diagnosis can be made by a positive response to the nasal allergen challenge (NAC) (the gold standard for diagnosis) in the absence of skin prick test and/or serum allergenspecific immunoglobulin E. Clinical and epidemiological studies have demonstrated that LAR affects individuals from different countries, races, and age ranges. Several studies have shown that the onset of nasal symptoms occurs during childhood in a significant proportion of LAR individuals. Evidence of LAR has been growing, especially in pediatric and Asian populations. A review of the literature reveals that most LAR studies of pediatric populations have appeared in the last three years. The prevalence of LAR in children ranges from 3.7% to 66.6%, and similar to what has been observed in adults, prevalence is higher in Western countries. Publications have shown that LAR in children can be either seasonal or perennial, and diagnosis of LAR confirmed by NAC have been reported with numerous allergens (house dust mites, pollens, molds, and dander). These findings illustrate that LAR is an important differential diagnosis in children with presumed non-allergic rhinitis, and a through review of the very recent literature can contribute to the clinical identification and diagnosis of LAR in children with no evidence of systemic atopy, as well as update readers' knowledge of the topic.

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Local allergic conjunctivitis: a phenotype of allergic conjunctivitis

Cited by 35 publications

References 26 publications

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

Local allergic rhinitis: a pediatric perspective

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