Local allergic rhinitis: natural history

Rondón, Carmen; Campo, Paloma; Doña, I; Roca, F. de la; López, Natalia Blanca; Blanca, Miguel

doi:10.1186/2045-7022-3-s2-o1

Cited by 1 publication

(5 citation statements)

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“…Patients had a direct or dual response to NAPT, followed by release of triptase, ECP and sIgE in nasal secretions. A significant finding in the two studies was a progressive increase in the level of the nasal sIgE from 1 to 24 hours after the NAPT [12,13]. An immediate response was presented with a significant increase in the level of triptase 15 minutes to 1 h after the exposure compared with the baseline values where patients with delayed dual responses reacted to increased triptase from 15 minutes to 6 hours [12].…”

Section: Positive Response To Nasal Allergen Provocation Testmentioning

confidence: 88%

“…Several studies have confirmed that more than 47% of patients with a previous diagnosis of IR have LAR with a positive NAPT response followed by a subjective (symptomatic) score and objective parameters (acoustic rhinometry, anterior rhinomanometry, nasal secretions with presence of sIgE and inflammatory mediators) [6,8,9,[11][12][13]. The first kinetic study of local production of IgE and inflammatory mediators after NAPT was administered to patients with LAR sensitized to grass pollen [12].…”

Section: Positive Response To Nasal Allergen Provocation Testmentioning

confidence: 99%

“…The first kinetic study of local production of IgE and inflammatory mediators after NAPT was administered to patients with LAR sensitized to grass pollen [12]. An immediate response was presented with a significant increase in the level of triptase 15 minutes to 1 h after the exposure compared with the baseline values where patients with delayed dual responses reacted to increased triptase from 15 minutes to 6 hours [12]. Patients had a direct or dual response to NAPT, followed by release of triptase, ECP and sIgE in nasal secretions.…”

Section: Positive Response To Nasal Allergen Provocation Testmentioning

confidence: 99%

“…Patients with LAR have typical symptoms of AR (rhinorrhea, nasal blockage, runny and itching nose), which is usually associated with ocular symptoms and a good response to oral antihistamines and nasal corticosteroids [8,9,12]. Patients with LAR, as well as those with AR, have anterior rhinorrhea, nasal itching and secretion as the most common symptoms [8,9].…”

Section: Clinical Manifestations Nasal Symptoms and Comorbiditiesmentioning

confidence: 99%

“…This discovery preceded the development of the idea of local allergic rhinitis (LAR), as well as the state of the local allergic response of the nasal mucosa in the absence of atopy [7]. Further research in the field of LAR was conducted by a group of Spanish ear, nose and throat (ENT) allergists led by Rondon et al This condition is characterized by the local production of sIgE antibodies [1,8,9], TH2 inflammatory response [5,[7][8][9][10], the positive response to nasal allergen provocation test (NAPT) [6,8,9,11] with overt symptoms and increased levels of sIgE, tryptase and eosinophil cationic protein (ECP) in nasal secretions [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Local allergic rhinitis

et al. 2014

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Local allergic rhinitis is a localized allergic response of the nasal mucosa to aeroallergens in the absence of atopy with characteristic production of specific local immunoglobulin E antibodies in the nasal mucosa, T helper type 2 cellular infiltration response during the exposure to aeroallergens and positive results via the nasal allergic provocation test with the release of inflammatory mediators (triptase and eosinophil cationic proteins). Even though the prevalence of local allergic rhinitis has been and is still being investigated, a large number of patients with diagnosed non-allergic rhinitis or idiopathic rhinitis are currently classified as having local allergic rhinitis. The causes of local allergic rhinitis are most commonly house dust, dust mites, pollens and many others. Diagnosis of local allergic rhinitis is made using nasal allergen provocation tests when the prick test for standard inhalation allergens and the serum specific immunoglobulin analysis for aeroallergens are negative. The increasing amount of data on localized allergic response in non-atopic patients asks for many answers regarding local allergic rhinitis. These answers can be obtained by a study on the prevalence and incidence in children and adults, the impact of positive family atopy in the development of disease, the impact of associated diseases of the lower respiratory tract and conjunctiva, the effectiveness of drug treatment and the issue of administration of specific immunotherapy. SažetakLokalni alergijski rinitis lokalizovani je alergijski odgovor nosne mukoze na aeoroalergen u odsustvu atopije, sa karakterističnom produkcijom lokalnih specifičnih imunoglobulin E antitela u nosnoj mukozi, T helper type 2 odgovorom mukozne ćelijske infiltracije tokom ekspozicije aeroalergenima i pozitivnim nazalnim alergijskim provokacionim testom (odgovorom) sa oslobađanjem inflamatornih medijatora (triptaze i eozinofilnog katjonik proteina). Iako se prevalencija lokalnog alergijskog rinitisa ispituje, veliki broj pacijenata sa dijagnozom nealergijskog rinitisa ili idiopatskog rinitisa sada je klasifikovana kao lokalni alergijski rinitis. Uzročnici su najčešće kućna prašina, grinje, poleni i mnogi drugi. Dijagnoza se postavlja nazalnim alergenskim provokacionim testom, jer je prik test na standardne inhalatorne alergene negativan, negativan je i nalaz serumskih specifičnih imunoglobulin na aeroalergene. Povećani broj podataka o lokalizovanom alergijskom odgovoru kod "neatopičara", traži mnoge odgovore o lokalnom alergijskom rinitisu: studije o prevalenciji i incidenciji kod dece i odraslih, uticaj pozitivne porodične atopije u razvoju bolesti, uticaj udruženih oboljenja donjih disajnih puteva i konjuktivitisa, efikasnost farmakološke terapije i pitanje primene specifične imunoterapije.

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Section: Positive Response To Nasal Allergen Provocation Testmentioning

confidence: 88%