Local anaesthetic activity of β-caryophyllene

Ghelardini, Carla; Galeotti, Nicoletta; Mannelli, Lorenzo Di Cesare; Mazzanti, Gabriela; Bartolini, Alessandro

doi:10.1016/s0014-827x(01)01092-8

Cited by 269 publications

(190 citation statements)

References 4 publications

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“…Essential oils rich in sesquiterpenes present biological properties which include spasmolytic, 24 local anaesthetic, 25 anti-inflammatory, 26 antimicrobial 23 and antifungal action. 27 Calamusenone, the major component found here, is frequently isolated from Acorus calamus, 17,28 a semi-aquatic plant of the Araceae family found in central Asia, India, North America and Europe.…”

Section: -22mentioning

confidence: 99%

Chemical composition and antimicrobial activity of the essential oil of Hyptis pectinata (l.) Poit.

Santos¹,

Costa²,

Alves³

et al. 2008

Quím. Nova

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ChemiCal Composition and antimiCrobial aCtivity of the essential oil ofEssential oil was extracted from leaves of Hyptis pectinata using hydrodistillation, and its composition determined using GC-FID and GC-MS. Chemical analysis showed that there was a predominance of sesquiterpenes, of which b-caryophyllene (18.34%), caryophyllene oxide (18.00%) and calamusenone (24.68%) were measured for the first time in the genus Hyptis. Twenty-one compounds were identified, and calamusenone was isolated using preparative thin layer chromatography with a silica gel plate (60 PF 254 ). The minimal inhibitory concentration (MIC) and minimal microbicidal concentration (MMC) were determined for various pathogenic microorganisms. H. pectinata oil was most effective against Gram (+) bacteria and yeasts.

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Section: -22mentioning

confidence: 99%

Chemical composition and antimicrobial activity of the essential oil of Hyptis pectinata (l.) Poit.

Santos¹,

Costa²,

Alves³

et al. 2008

Quím. Nova

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“…É o caso do limoneno na sua forma enantiômera (D-limoneno), na terapia de câncer de mama, pâncreas e próstata [11,21] e do β-cariofileno que apresenta atividade espasmolítica [6], anestésica local [19] e antiinflamatória [27].…”

Section: ] Tendo Aproximadamente Teor Sete Vezes Superior Aounclassified

Composição química dos frutos de Campomanesia adamantium (Cambessédes) O.Berg

Vallilo¹,

Lamardo²,

Gaberlotti³

et al. 2006

Ciênc. Tecnol. Aliment.

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RESUMOFrutos de C. adamantium (Myrtaceae), coletados em diferentes estádios de amadurecimento na Floresta Estadual de Assis -São Paulo -, foram avaliados quanto à composição nutricional, perfil de óleo volátil e presença de elementos inorgânicos. O fruto apresentou alto teor de água (75,9%), baixo pH (4,3) e elevada acidez (1,2 g em ácido cítrico). Além disso, destacou-se como excelente fonte de vitamina C (234 mg 100 g -1 ). No óleo volátil, foi possível identificar 40 componentes que corresponderam a 93,3% dos compostos presentes. Como componentes majoritários do óleo, destacaram-se o α-pineno (10,6%), limoneno (10,1%) e o β-(z)-ocimeno (9,2%). Entre os minerais (16), os principais constituintes foram o K (1304 mg kg -1 ), Ca, P e Mg na concentração compreendida entre 165 e 175 mg kg -1 e, como micro elementos, o Fe (11,3 mg kg -1 ) e o Al (15,9 mg kg -1 ). O valor energético do fruto (66,3 kcal 100 g -1 ) deveu-se quase que exclusivamente aos carboidratos totais (11,6%). Palavras-chave: Myrtaceae, gabiroba, composição centesimal, valor calórico, óleo essencial.collected in different stages of maturation at Assis State Forest, São Paulo, were evaluated for nutritional composition, volatile oil profile and presence of inorganic elements. The fruit showed a high level of moisture (75.9%), low pH (4.3) and high acidity (1.2 g in citric acid). It is a significant source of vitamin C (234 mg 100 g -1 ). In the volatile oil, 40 compounds were identified corresponding to 93.3% of the oil contents. The major components were α-pinene (10.6%), limonene (10.1%) and the β-(z)-ocimene (9.2%). Among the inorganic elements the nutrients exceed: K (1304 mg kg -1 ), Ca, P, and Mg from 165 to 175 mg kg -1 concentration and the microelements Fe (11.3 mg kg -1 ) and Al (15.9 mg kg -1 ). The caloric value (66.3 kcal 100 g -1 ) was due almost exclusively to the total carbohydrates (11.6%). Keywords: Myrtaceae, gabiroba, centensimal composition, caloric value, essential oil. -INTRODUÇÃOOs frutos de C. adamantium, popularmente conhecidos como "gabiroba" ou "gabiroba-do-mato", apresentam formato redondo, de coloração que varia do verde escuro ao verde claro e amarelo, e exalam aroma cítrico, agradável ao olfato. Essa espécie pertence à família Myrtaceae, composta por mais de 100 gêneros e 3.600 espécies. A planta se desenvolve de forma arbustiva, atingindo até 2 m de altura, muito ramificada e com ramos delgados. Suas folhas são simples, opostas, ovais ou elípticas, membranáceas ou cartáceas, com base aguda à obtusa, apresentando ápice agudo com cerca de 4 cm de comprimento e 2 cm de largura [14].A planta floresce nos meses de setembro a novembro, com flores brancas, solitárias, axilares ou terminais. Os frutos amadurecem de novembro a dezembro, sendo comestíveis e consumidos por várias espécies de pássaros e mamíferos [8,25].Citações da literatura indicam a ocorrência da espécie em campos de cerrado, no Centro -Oeste e no Sudeste do Brasil e, em alguns casos, chegando a ultrapassar os limites do País para alcançar as terras do Urugua...

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“…Affonso et al,6 in studies about tissue cultures of Lantana camara, have also verified an increase in caryophyllene by addition of TDZ. β-caryophyllene has antiinflammatory and anesthetic properties, 15 furthermore it has been used in spices, soaps, detergents, creams and lotions, and also in a variety of food products and beverages. 16 The enhancement in caryophyllene content is very interesting, considering its wide importance in pharmaceutical, cosmetic and food industries.…”

Section: Resultsmentioning

confidence: 99%

Leaf and root volatiles produced by tissue cultures of Alpinia zerumbet (pers.) Burtt & Smith under the influence of different plant growth regulators

2011

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Volatiles produced by plantlets of Alpinia zerumbet were obtained by means of simultaneous distillation-extraction (SDE). The effects of indole-3-acetic acid, kinetin, thidiazuron and 6-benzylaminopurine on leaf and root volatile composition obtained by tissue cultures were investigated. A higher content of β-pinene and a lower content of sabinene were observed in leaf volatile of plantlets cultured in control, IAA and IAA+ TDZ media, as compared with those of donor plants. In vitro conditions were favorable to increase caryophyllene content. Volatile compounds from the root were characterized mainly by camphene, fenchyl-acetate and bornyl acetate; which constitute about 60% of total volatile.

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Local anaesthetic activity of β-caryophyllene

Cited by 269 publications

References 4 publications

Chemical composition and antimicrobial activity of the essential oil of Hyptis pectinata (l.) Poit.

Chemical composition and antimicrobial activity of the essential oil of Hyptis pectinata (l.) Poit.

Composição química dos frutos de Campomanesia adamantium (Cambessédes) O.Berg

Leaf and root volatiles produced by tissue cultures of Alpinia zerumbet (pers.) Burtt & Smith under the influence of different plant growth regulators

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