Local and global consequences of reward-evoked striatal dopamine release

Li, Nan; Jasanoff, Alan

doi:10.1038/s41586-020-2158-3

Cited by 62 publications

(51 citation statements)

References 44 publications

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“…The mesolimbic pathway originates in the VTA, which sends DAergic axons to the prefrontal cortex, nucleus accumbens (nAc), amygdala, cingulate gyrus, hippocampus, and piriformis complex of the olfactory bulb and the insular cortex [30]. DAergic innervation of the amygdala and cingulate gyrus is highly involved in the formation and processing of emotions.…”

Section: Figurementioning

confidence: 99%

Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

Speranza

Porzio

Viggiano

et al. 2021

Cells

174

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Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement of behavior, and selected higher cognitive functions. Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson’s disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction. Here we will discuss the current insights on the role of DA in motor control and reward learning mechanisms and its involvement in the modulation of synaptic dynamics through different pathways. In particular, we will consider the role of DA as neuromodulator of two forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD) in several cortical and subcortical areas. Finally, we will delineate how the effect of DA on dendritic spines places this molecule at the interface between the motor and the cognitive systems. Specifically, we will be focusing on PD, vascular dementia, and schizophrenia.

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Section: Figurementioning

confidence: 99%

Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

Speranza

Porzio

Viggiano

et al. 2021

Cells

174

View full text Add to dashboard Cite

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“…The cognitive and behavioral effects of striatal dopamine signaling are related to its influence on large-scale neural activity. Recent work in rodents has begun to characterize the nature of the relationship between local striatal signaling and cortex-wide effects ( 1 – 3 ). Striatal dopamine release, secondary to optogenetic or chemogenetic activation of mesolimbic pathways ( 2 , 3 ) or hypothalamic self-stimulation ( 1 ), has been shown to affect cortical activity, as has selective overexpression of striatal D2 receptors ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recent work in rodents has begun to characterize the nature of the relationship between local striatal signaling and cortex-wide effects ( 1 – 3 ). Striatal dopamine release, secondary to optogenetic or chemogenetic activation of mesolimbic pathways ( 2 , 3 ) or hypothalamic self-stimulation ( 1 ), has been shown to affect cortical activity, as has selective overexpression of striatal D2 receptors ( 4 ). This correspondence between striatal dopamine and cortical activity is of relevance, given the frequent simultaneous disruption of striatal dopaminergic function and cortical function in neuropsychiatric illness ( 5 , 6 ) and also for understanding the broad consequences of dopamine modulating pharmacotherapies.…”

Section: Introductionmentioning

confidence: 99%

Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness

et al. 2021

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Dopamine signaling is constrained to discrete tracts yet has brain-wide effects on neural activity. The nature of this relationship between local dopamine signaling and brain-wide neuronal activity is not clearly defined and has relevance for neuropsychiatric illnesses where abnormalities of cortical activity and dopamine signaling coexist. Using simultaneous PET-MRI in healthy volunteers, we find strong evidence that patterns of striatal dopamine signaling and cortical blood flow (an index of local neural activity) contain shared information. This shared information links amphetamine-induced changes in gradients of striatal dopamine receptor availability to changes in brain-wide blood flow and is informed by spatial patterns of gene expression enriched for genes implicated in schizophrenia, bipolar disorder, and autism spectrum disorder. These results advance our knowledge of the relationship between cortical function and striatal dopamine, with relevance for understanding pathophysiology and treatment of diseases in which simultaneous aberrations of these systems exist.

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“…Though FSCV has been a common method of detecting in vivo neurotransmitters for decades, an increasing number of optical detection alternatives exist that could also pair with fMRI 17,48–50 . A dopamine-sensitive protein-based MRI contrast agent has been used with BOLD 13 , and dopamine dynamics have been explored using near-infrared fluorescent sensors 15 and genetically encoded fluorescent sensors 14,16 . These techniques require either infusion cannulae or optical fibers for contrast agent dispersal or fluorescence detection, respectively, which use fMRI-compatible materials.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous fMRI and fast-scan cyclic voltammetry bridges oxygenation and neurotransmitter dynamics across spatiotemporal scales

Walton

Verber

Lee

et al. 2021

Preprint

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The vascular contributions of neurotransmitters to the hemodynamic response are gaining more attention in neuroimaging studies, as many neurotransmitters are vasomodulatory. To date, well-established electrochemical techniques that detect neurotransmission in high magnetic field environments are limited. Here, we propose an experimental setting enabling simultaneous fast-scan cyclic voltammetry (FSCV) and blood oxygenation-dependent functional magnetic imaging (BOLD fMRI) to measure both local tissue oxygen and dopamine responses, and global BOLD changes, respectively. By using MR-compatible materials and the proposed data acquisition schemes, FSCV detected physiological analyte concentrations with high spatiotemporal resolution inside of a 9.4 T MRI bore. We found that tissue oxygen and BOLD correlate strongly, and brain regions that encode dopamine amplitude differences can be identified via modeling simultaneously acquired dopamine FSCV and BOLD fMRI time-courses. This technique provides complementary neurochemical and hemodynamic information and expands the scope of studying the influence of local neurotransmitter release over the entire brain.

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Local and global consequences of reward-evoked striatal dopamine release

Cited by 62 publications

References 44 publications

Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness

Simultaneous fMRI and fast-scan cyclic voltammetry bridges oxygenation and neurotransmitter dynamics across spatiotemporal scales

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