The efficacy of Milsana Ò VP 1999 and 2000 (a formulated plant extract of Reynoutria sachalinensis), known to induce resistance to powdery mildew on cucumbers, was tested against Leveillula taurica (Le´v.) Arn. on greenhouse tomato. In four out of five trials, Milsana Ò achieved a disease reduction ranging from 42.2 to 64.6%. In one trial only, its efficacy was exceptionally low (23%). Application rates and disease pressure proved to be the main factors affecting the level of control. Milsana Ò was significantly less effective than fungicides (alternated DMIs and penconazole) in situ. In contrast, Milsana Ò was equally effective to wettable sulphur indicating that its effect was rather preventive than curative. The level of efficacy achieved by either Milsana Ò or fungicides did not result in a significant increase of yield. Laboratory tests showed that Milsana Ò (VP 1999) had a direct effect on conidial germination. Whether this effect significantly contributes to its field efficacy, remains to be elucidated. Overall, results indicate that Milsana Ò could play an important role in disease management of powdery mildew in organic and low input tomato production.