Local and systemic effects of aging on acute pancreatitis

Coelho, Ana Maria M.; Sampietre, Sandra N.; Machado, Maria Aparecida Miranda de Paula; Cunha, J.E.M.; Chaib, Eleazar; D’Albuquerque, Luiz Carneiro

doi:10.1016/j.hpb.2016.02.863

Cited by 2 publications

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“…The underlying mechanism of the above condition is still debate. A view proposed in a literature that the increasing age was associated to the loss of protective proteins of AP which led an adverse clinical course in oldest patients of the disease [28]. Pre-existing comorbidities such as diabetes, chronic renal disease would influence the physiological functions of aging AP patients which causing a more severe inflammatory response reflected as primary clinical manifestation of the disease [13].…”

Section: Discussionmentioning

confidence: 99%

The clinical traits of acute pancreatitis in aging patients: a retrospective analysis of 473 cases

Lü¹,

Yu²,

Xie³

2020

Preprint

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Background The incidence of acute pancreatitis in aging patients has increasing in recent years. Controversial results about clinical outcomes of acute pancreatitis in aging patients were reported in different literature. The aim of our study was to compare the clinical outcomes of AP in aging patients between 60-79 years old and over 80 years old. Methods 80 patients aged ≥ 80 years old(oldest group) were compared to 393 patients aged 60 to 79 years old(older group). The clinical course, biochemical, radiological data were enrolled. The primary endpoint was to compare the death rate, intensive care unit admission rate and in-hospital length of stay(LOS). The secondary endpoint was operative treatment and the complications of AP. Results Abdominal symptom of abdominal pain (61.3% vs 46.3%, P=0.013) was less in oldest group, while diarrhea(18.3% vs 30.0%, P=0.018), jaundice(8.9% vs 17.5%, P=0.021), dyspnea(11.5% vs 26.3%, P=0.001) were more obvious in older group than oldest group. A higher death rate (8.9% vs 16.3%, P = 0.003) and longer hospital length of stay (11.51±10.19 vs 15.26±11.04, P = 0.001) were found in aging patients aged ≥80 years old. Mean BMI was lower in oldest group compared to older group(22.36±2.89 vs 21.07±3.18, P = 0.001). Multivariate analysis identified aged over 80 years(OR 3.299, 95%CI 1.316-8.269, P=0.011) and organ failure(P<0.05) as independent risk factors of mortality. More severe of AP(OR 11.722, 95%CI 4.780-28.764, P=0.001), abdominal pain(OR 1.906, 95%CI 1.052-3.453, P=0.033) and organ failure(P<0.05) were recognized as influencing intensive care unit rate. Aging patients aged over 80 years old(OR 0.149, 95%CI 2.027-6.268, P=0.001), more severe of AP(OR 0.218, 95%CI 1.567-4.322, P=0.001), female(OR 0.093, 95%CI 0.336-3.542, P=0.018), Jaundice(OR 0.080, 95%CI 0.146-5.324, P=0.038), operative treatment(P<0.05) and organ failure(P<0.05) were the risk factors for LOS.

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Section: Discussionmentioning

confidence: 99%

The clinical traits of acute pancreatitis in aging patients: a retrospective analysis of 473 cases

Lü¹,

Yu²,

Xie³

2020

Preprint

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“…An islet—β death promotes reduction in insulin secretion and increased blood glycemic index. Ultimately, an abnormal or no insulin secretion results in immune damage, inflammation damage, and fat infiltration leading to pancreas shrinkage (Coelho et al, 2019; Huang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Near‐infrared optical spectroscopy for pancreas shrinkage estimation with multi synchrosqueezing transform and multivariate regression model

Priyadharshini¹,

Prem²,

Suresh³

2021

Microscopy Res & Technique

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In this article, we proposed a method to estimate pancreas shrinkage with pancreas β cell insulin secretion. The β cells in the pancreas secrete insulin and digestive enzymes after food consumption. Conventionally, the pancreas structure estimation is done with magnetic resonance imaging (MRI) and ultrasound imaging techniques. However, the structure of the pancreas changes due to islet cell death. The presence of islet cells is detected through near infrared (NIR) spectroscopy signal acquired from the epigastric region (pancreas) of the abdomen. Subsequently, the NIR spectroscopy signal from the pancreas is analyzed with multi synchrosqueezing transform (MSST); whereas, the β cell insulin secretion varies for diabetic and nondiabetic persons. The existence of β cell and insulin secretion correlates with Root Mean Square (RMS) and kurtosis via a multivariate regression model to evaluate pancreas shrinkage. In terms of numerical results, NIR spectroscopy signal from the pancreas was obtained for about 20 nondiabetic and 20 diabetic persons. The pancreas shrinkage was estimated with 88% accuracy. The results are validated with MRI pancreas images for earlier detection of the apoptotic pancreas. The pancreas shrinkage causes lower insulin emission and unpredictable blood glucose in diabetic patients. Analysis of NIR spectroscopy signals of the pancreas with MSST was done to obtain higher‐order and lower‐order frequency components.

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Local and systemic effects of aging on acute pancreatitis

Cited by 2 publications

References 0 publications

The clinical traits of acute pancreatitis in aging patients: a retrospective analysis of 473 cases

The clinical traits of acute pancreatitis in aging patients: a retrospective analysis of 473 cases

Near‐infrared optical spectroscopy for pancreas shrinkage estimation with multi synchrosqueezing transform and multivariate regression model

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