Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

Hajishengallis, George; Chavakis, Triantafyllos

doi:10.1038/s41577-020-00488-6

Cited by 842 publications

(764 citation statements)

References 161 publications

(274 reference statements)

Supporting

Mentioning

743

Contrasting

Unclassified

Order By: Relevance

“…First, this group of athletes has a thorough and continuous medical follow-up, though oral health seems somehow neglected, and this fact has been previously highlighted [ 22 ]. Second, the systemic consequences of periodontitis, for instance the leukocytosis and mild anemia [ 26 ], the increase in inflammatory mediators (CRP and cytokines) [ 27 , 28 ] and harmful consequences for health [ 29 ] may place these athletes at higher risk. Unfortunately, to date, the number of studies on the systemic effect of periodontitis in elite athletes is scarce and further studies are needed to clarify this topic.…”

Section: Discussionmentioning

confidence: 99%

Periodontal Health, Nutrition and Anthropometry in Professional Footballers: A Preliminary Study

Botelho

Vicente²,

Dias³

et al. 2021

Nutrients

View full text Add to dashboard Cite

Poor oral health in elite sport is a pressing issue, however little is known about the periodontal status of professional footballers. The aim of this study was to examine the prevalence of periodontitis in a group of professional footballers and its association with nutritional parameters and self-report non-traumatic injuries. Additionally, we assessed its association with anthropometric, dietary inflammatory load and self-reported muscular and/or articular injuries. Twenty-two professional footballers were evaluated at the beginning of the 2020–2021 season via full-mouth periodontal inspection, anthropometric measurements and the application of the dietary inflammatory index through a food intake measurement of 24 h dietary recall on two different days. Self-reporting non-traumatic muscular and articular injuries for the past 6 months were recorded from each athlete. Then we compared clinical measurements according to the periodontal status and we correlated age, periodontal and nutritional parameters. Overall, the prevalence of periodontitis was 40.9% and peri-implantitis was also observed. No significant differences were found regarding age or nutritional parameters according to the periodontal status. More non-traumatic muscular events in the past 6 months were found in the periodontitis group (55.6% vs. 38.4%), although the difference was non-significant. Both clinical attachment loss, periodontal pocket depth and the periodontal epithelial surface area revealed a significant moderate correlation with the percentage of fat mass, muscle mass, muscle mass index and total adipose folds. This group of professional footballers showed an alarming prevalence of periodontitis. Further studies shall examine whether periodontitis and periodontal treatment impact the performance of this group of athletes.

show abstract

Section: Discussionmentioning

confidence: 99%

Periodontal Health, Nutrition and Anthropometry in Professional Footballers: A Preliminary Study

Botelho

Vicente²,

Dias³

et al. 2021

Nutrients

View full text Add to dashboard Cite

show abstract

“…Recent studies have revealed that oral gut bacteria are associated with the pathogenesis of IBD [47,48]. It has been reported that oral resident bacteria, such as Fusobacteriaceae and Pasteurellaceae, are accumulated in the intestinal mucosa of patients with IBD [49,50].…”

Section: Alteration Of the Microbial Composition In Ibdmentioning

confidence: 99%

Diet–Microbiota Interactions in Inflammatory Bowel Disease

Sugihara

Kamada

2021

Nutrients

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. Although the precise etiology of IBD is largely unknown, it is widely thought that diet contributes to the development of IBD. Diet shapes the composition of the gut microbiota, which plays critical roles in intestinal homeostasis. In contrast, intestinal inflammation induces gut dysbiosis and may affect the use of dietary nutrients by host cells and the gut microbiota. The interaction of diet and the gut microbiota is perturbed in patients with IBD. Herein, we review the current knowledge of diet and gut microbiota interaction in intestinal homeostasis. We also discuss alterations of diet and gut microbiota interaction that influence the outcome and the nutritional treatment of IBD. Understanding the complex relationships between diet and the gut microbiota provides crucial insight into the pathogenesis of IBD and advances the development of new therapeutic approaches.

show abstract

“…It has been estimated that a patient with periodontitis experiences several occasions of bacteremia each day lasting for a total up to 3 hours [ 3 ]. Furthermore, a patient with periodontitis can have a wound bed estimated to cover a surface area of 8–20 cm 2 [ 34 ] from which bacteria have easy access to the blood stream [ 20 ]. Bacteria from periodontitis can also be transferred to the brain via other routes such as the trigeminal nerve, circumventricular organs, perivascular spaces, and by olfactory unsheathing cells acting as Trojan horses [ 20 ].…”

Section: Relationship Between Periodontitis and Alzheimer’s Diseasementioning

confidence: 99%

Can Porphyromonas gingivalis Contribute to Alzheimer’s Disease Already at the Stage of Gingivitis?

Olsen

2021

ADR

View full text Add to dashboard Cite

Alzheimer’s disease (AD) has been associated with periodontitis, which starts as gingivitis. Similar to periodontitis, gingivitis bacteria, bacterial products, and inflammatory mediators can travel to the brain via the blood stream and promote brain inflammation. Periodontal pathogens such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, both associated with AD, have been found in dental plaque of children already at the age of 3. It is suggested that these bacteria during long-term exposure may drive microglia (brain resident macrophage cells) into a pro-inflammatory M1 phase where they contribute to AD rather than protect against it. This notion comes from studies in mice showing that microglia actually can “remember” previous inflammatory challenge and become “trained” or “tolerant” to toxins like lipopolysaccharide. If gingivitis has an impact on AD, which should be verified, AD prophylaxis should start already at this pre-periodontitis stage with removal of supragingival plaque.

show abstract

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

Cited by 842 publications

References 161 publications

Periodontal Health, Nutrition and Anthropometry in Professional Footballers: A Preliminary Study

Periodontal Health, Nutrition and Anthropometry in Professional Footballers: A Preliminary Study

Diet–Microbiota Interactions in Inflammatory Bowel Disease

Can Porphyromonas gingivalis Contribute to Alzheimer’s Disease Already at the Stage of Gingivitis?

Contact Info

Product

Resources

About