Local and Systemic Vegf-А Production in Complicated Proliferative Diabetic Retinopathy

Нероев, В. В.; Зайцева, О В; Балацкая, Н. В.; Курчаева, З В

doi:10.15789/1563-0625-2016-4-357-364

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…We found that vitreous VEGF levels were not significantly effected by the type or duration of diabetes, severity of arterial hypertension, state of the lens or whether the patient had or had not past panretinal laser photocoagulation. Our findings are in agreement with those reported by others regarding the effect of the type or duration of diabetes on vitreous VEGF levels [15]; however, they are in disagreement with those reported by others regarding the effect of the state of the lens and whether the patient had past panretinal laser photocoagulation. Although there have been reports on an increased risk of secondary neovascular glaucoma after phacoemulsification with IOL implantation in patients with PDR [19,20], we did not find this in our patients.…”

Section: Discussionsupporting

confidence: 80%

“…In studies by Neroev and colleagues [15,27], VEGF levels in the vitreous, subretinal fluid and serum were highest in the eyes operated for complicated PDR without preliminary anti-VEGF therapy, with mean values of 1151.6 pg/ml, 3490 pg/ml and 226.4 pg/ml for the vitreous, subretinal fluid, and serum, respectively, compared to 205.6±175.0 pg/ml, 775.4±560 pg/ml, and 140.5 ± 64.2 pg/ml, respectively, in the eyes operated for PDR with a stable course without preliminary anti-VEGF therapy. In addition, among eyes with PDR, tear VEGF-A levels were higher in those with a fibrovascular epiretinal membrane compared to those with a fibroglial epiretinal membrane.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, among eyes with PDR, tear VEGF-A levels were higher in those with a fibrovascular epiretinal membrane compared to those with a fibroglial epiretinal membrane. Moreover, tear VEGF-A levels of 3490 pg/ml or above were significantly associated with the presence of active neovascularization within the eye, and may be used as a prognostic criterion for the presence of active neovascularization within an eye with opaque media [15,27].…”

Section: Discussionmentioning

confidence: 99%

“…VEGF levels in the vitreous, subretinal fluid and serum were found to vary with pathological changes in the retina and vitreous [15][16][17]. In addition, it is in proliferative diabetic retinopathy (PDR) that vitreous VEGF levels are commonly highest.…”

Section: Introductionmentioning

confidence: 99%

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Vitreous VEGF levels among patients with proliferative diabetic retinopathy depending on the general clinical status and ocular status

Ponomarchuk¹,

Velychko²,

Umanets³

2021

Oftalmol Zh

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The most common cause of visual impairment in patients with diabetic retinopathy is the pathology progression to the proliferative stage which is accompanied by apparent fibrovascular proliferation, development of tractional retinal detachment and/or vitreous hemorrhage. Vascular endothelial growth factor (VEGF) is the most important in the pathogenesis of ocular microvascular changes in diabetes. Purpose: To assess vitreous VEGF levels in the proliferative diabetic retinopathy (PDR) patients not initially treated with anti-VEGF agents, depending on the general clinical status and ocular status. Material and Methods: Forty-one patients (45 eyes) aged 19 to 81 years with neovascular glial PDR and epiretinal membrane with a marked proliferative component were involved in the study. Each patient underwent a 25G three-port vitrectomy during which a vitreous specimen was collected. Vitreous VEGF levels were determined by a three-step enzyme-linked immunosorbent assay. Results: We managed to assess total vitreous VEGF levels in 44 of the 45 eyes. Patients with PDR had elevated total vitreous VEGF levels, with a mean value of 757.69 ± 117 pg/ml, confirming the involvement of VEGF in pathological intraocular angiogenesis. There was a significant difference in vitreous VEGF levels between PDR patients with a fibrovascular membrane with a marked proliferative component (997.0±151.8 pg/ ml) and those with a fibrovascular membrane with a moderate proliferative component (244.9 ± 53.7 pg/ml) (F = 10.3; р = 0.0025).

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vitreous VEGF levels among patients with proliferative diabetic retinopathy depending on the general clinical status and ocular status

Ponomarchuk¹,

Velychko²,

Umanets³

2021

Oftalmol Zh

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“…We think that this could be because in conditions of extent atherosclerosis and systemic vascular remodeling, there can be an increased migration of VEGFR2 hi -neutrophils into the tissue (mediated by both VEGFR and CXCR2), which leads to a decrease in their number in the systemic circulation [ 28 ]. In our opinion, the lack of interrelations between the serum VEGF level and the number of neutrophils of various subpopulations can be due to the fact that in the absence of clinically significant ischemic syndromes (patients with ASCVD were not included in the study), the serum VEGF level does not represent local tissue hypoxia, which was previously shown in examples of other diseases [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 91%

Associations between Circulating VEGFR2hi-Neutrophils and Carotid Plaque Burden in Patients Aged 40-64 without Established Atherosclerotic Cardiovascular Disease

Генкель

Долгушин

Батурина

et al. 2022

Journal of Immunology Research

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Background. Neutrophils expressing vascular endothelial growth factor receptor (VEGFR) represent a distinct subtype of neutrophils with proangiogenic properties. The purpose of this study was to identify the interrelations between circulating CD16hiCD11bhiCD62LloCXCR2hiVEGFR2hi-neutrophils and indicators of carotid plaque burden in patients without atherosclerotic cardiovascular diseases (ASCVD). Methods. The study included 145 patients, 51.7% men and 48.3% women, median age—49.0 years. All patients underwent carotid duplex ultrasound scanning. The maximal carotid plaque thickness was used as an indicator of carotid plaque burden. Also, carotid intima-media thickness (cIMT) and femoral IMT were measured. The phenotyping of neutrophil subpopulations was executed by the flow cytometry via the Navios 6/2. Results. The subpopulation of VEGFR2hi-neutrophils accounted for about 5% of the total pool of circulating neutrophils. A decrease in VEGFR2hi-neutrophils with an increase in carotid plaque burden was statistically significant ( p = 0.036 ). A decrease in VEGFR2hi- neutrophils < 4.52 % allowed to predict the presence of plaque with a maximum height > 2.1 mm (Q4), with sensitivity of 78.9% and specificity of 61.5% (AUC 0.693; 95% CI 0.575-0.811; p = 0.007 ). Inverse correlations were established between the carotid and femoral IMT and the absolute and relative number of VEGFR2hi-neutrophils ( p < 0.01 ). Conclusion. In patients aged 40-64 years without established ASCVD, with an increase in indicators of the carotid plaque burden, a significant decrease in the proportion of circulating VEGFR2hi-neutrophils was noticed. A decrease in the relative number of VEGFR2hi-neutrophils of less than 4.52% made it possible to predict the presence of extent carotid atherosclerosis with sensitivity of 78.9% and specificity of 61.5%.

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Possibilities of multicolor confocal scanning laser ophthalmoscopy in complex diagnostics of severe proliferative diabetic retinopathy

et al. 2019

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Диабетическая ретинопатия (ДР) является тяжелым поздним микрососудистым осложнением сахарного диабета (СД) и одной из ведущих причин слепоты в мире среди трудоспособного населения [1]. Число пациентов, страдающих СД, постоянно растет. Согласно прогнозам ВОЗ, к 2030 г. в мире бу-дет насчитываться 440 млн больных СД, что составит 7,7% от всего населения нашей планеты, тогда как в 2015 г. в мире диабетом страдали около 415 млн человек (6,4% населения) [1, 2]. По данным федераль

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Local and Systemic Vegf-А Production in Complicated Proliferative Diabetic Retinopathy

Cited by 4 publications

References 18 publications

Vitreous VEGF levels among patients with proliferative diabetic retinopathy depending on the general clinical status and ocular status

Vitreous VEGF levels among patients with proliferative diabetic retinopathy depending on the general clinical status and ocular status

Associations between Circulating VEGFR2hi-Neutrophils and Carotid Plaque Burden in Patients Aged 40-64 without Established Atherosclerotic Cardiovascular Disease

Possibilities of multicolor confocal scanning laser ophthalmoscopy in complex diagnostics of severe proliferative diabetic retinopathy

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