Local anesthesia and pain perception during amniocentesis: a randomized double blind placebo‐controlled trial

Elimian, Andrew; Goodman, Jean R.; Knudtson, Eric; Wagner, Andrew; Wilson, Patrick L.; Williams, Marvin

doi:10.1002/pd.4214

Cited by 6 publications

(11 citation statements)

References 8 publications

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“…Overall, 203 citations were retrieved after the omission of duplicates. Additionally, nine articles progressed to full-text screening, of which five studies met the eligibility criteria and were included in the quantitative synthesis ( Figure 1 ) ( 5 , 6 , 7 , 8 , 9 ) .…”

Section: Resultsmentioning

confidence: 99%

“…Several randomized controlled trials (RCTs) explored the capacity of lidocaine-mediated pain relief among pregnant women undergoing amniocentesis ( 5 , 6 , 7 , 8 , 9 ) . However, the findings of these RCTs were limited by various shortcomings, such as small sample sizes, relatively poor quality of studies, different routes of administration, and inconsistent reported results.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of lidocaine local anesthesia on pain perception during amniocentesis: A meta-analysis of randomized controlled trials

Albazee¹,

Sayad²,

Alnifise³

et al. 2022

tjod

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To evaluate the efficacy of lidocaine local analgesia on maternal pain reduction during amniocentesis. Web of Science, Scopus, PubMed, and CENTRAL databases were screened from inception and updated in July 2022. The included randomized controlled trials (RCTs) were evaluated for the risk of bias via the Cochrane tool. The primary outcome was pain perception using the 10 cm visual analog scale, and was summarized as mean difference (MD) with 95% confidence interval (CI) in a random-effects model. Subgroup analysis was performed according to the mode of administration. Meta-analysis was done via Review Manager software. We included five RCTs totaling 1004 women (lidocaine arm n=502 patients and control arm n=502 patients). Overall, there was no significant difference between both arms [MD=-0.21, 95% CI (-0.48, 0.07), p=0.80]. The pooled analysis showed homogeneity (p=0.13, I 2 =43%). Subgroup analysis according to the mode of administration showed that pain perception did not significantly differ between both arms when lidocaine was employed as injection [n=3 RCTs, MD=-0.26, 95% CI (-0.76, 0.23), p=0.29] or non-injection [n=2 RCTs, MD=-0.18, 95% CI (-0.55, 0.18), p=0.33]. The pooled analyses showed heterogeneity (p=0.05, I 2 =66%) and homogeneity (p=0.27, I 2 =19%), respectively. There was no noteworthy change concerning maternal pain perception between the lidocaine and control arms. Most women reported just minimal discomfort during amniocentesis. Counseling should educate patients that the pain they might experience during amniocentesis is comparable to venous blood sampling.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of lidocaine local anesthesia on pain perception during amniocentesis: A meta-analysis of randomized controlled trials

Albazee¹,

Sayad²,

Alnifise³

et al. 2022

tjod

View full text Add to dashboard Cite

show abstract

“…Elimian et al 18 who studied the local injection of lidocaine at the area of amniocentesis, found that there was a significant pain reduction during amniocentesis in the study group as compared to the control group. Local lidocaine injection can inhibit nerve conduction at the skin area, subcutaneous tissue, peritoneal, and uterus.…”

Section: Discussionmentioning

confidence: 98%

Cold therapy for pain relief during and after amniocentesis procedure: A randomized controlled trial

Benchahong

Pongrojpaw

Chanthasenanont

et al. 2021

J of Obstet and Gynaecol

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Aim To compare effects of cold therapy on patient pain score during and after amniocentesis procedure. Methods We performed a prospective randomized‐controlled study comparing the anticipated pain, perceived pain during the procedure, and pain after 15 and 30 min of amniocentesis between pregnant women receiving cold therapy before (group 1), after (group 2), and both before and after amniocentesis (group 3) with a control group (group 4). Pain was measured using a visual analog scale (VAS) score. Results A total of 480 participants were recruited and randomly assigned into four groups of 120 each. Anticipated pain scores in all groups were not statistically different. When compared with group 4, groups 1 and 3 experienced significant pain reduction during amniocentesis, while VAS scores at 15 and 30 min after amniocentesis in groups 1–3 were significantly lower as compared to group 4. Conclusion Cold therapy both before and after amniocentesis procedure is most effective in pain reduction. It encourages the pregnant woman's cooperation during the procedure and provides a good amniocentesis experience. Application of cold compression is also beneficial in other aspects as it is simple, safe, convenient, and yet reusable and economically efficient for routine use in all pregnant women undergoing amniocentesis.

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“…1,2 Several studies have evaluated various methods to decrease pain during amniocentesis procedure using oral paracetamol, cryoanalgesia, music listening, and Xylocaine as anesthetic agent. [3][4][5][6][7][8] However, there is no conclusive evidence about the most effective method for analgesia during amniocentesis. 9 The aim of this study was to conduct a randomized controlled trial to evaluate the effect of Xylocaine spray on maternal abdominal wall for analgesia during amniocentesis.…”

Section: Introductionmentioning

confidence: 99%

“…However, this pain during the procedure can cause discomfort and anxiety to some patients . Several studies have evaluated various methods to decrease pain during amniocentesis procedure using oral paracetamol, cryoanalgesia, music listening, and Xylocaine as anesthetic agent . However, there is no conclusive evidence about the most effective method for analgesia during amniocentesis .…”

Section: Introductionmentioning

confidence: 99%

Effect of Xylocaine spray for analgesia during amniocentesis: a randomized controlled trial

2019

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Objective To compare the effect of Xylocaine spray on pain score during amniocentesis Methods Singleton pregnant women undergoing amniocentesis were recruited. Each participant was randomly assigned into three groups. Group 1 (Xylocaine spray): 1 min before the procedure, 8 puffs (80 mg) of 10% Lidocaine spray were sprayed on abdominal wall: group 2 (placebo): 8 puffs of sterile normal saline were sprayed: and group 3 (control): no spray was used. The participants rated their pain through a 10‐cm visual analog scale before, during, and 30 min after amniocentesis. Main outcome of study was difference in pain score among three groups. Results A total 570 pregnant women participated; 191 in the Xylocaine group, 193 in placebo group, and 186 in control group. Baseline pain was not different. The median procedural pain score was significantly different (2.3, 3.3, and 2.8 respectively; p 0.001). Post‐hoc analysis showed that the procedural pain score in Xylocaine group was significantly lower than placebo or control group (p value <0.001 and 0.02, respectively). However, the pain score 30 min after procedure was not different. Conclusion Xylocaine spray can significantly decrease pain during amniocentesis, however, the clinical significance is unclear given that the procedure‐related discomfort is mild and short‐lived.

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Local anesthesia and pain perception during amniocentesis: a randomized double blind placebo‐controlled trial

Abstract: Local anesthetic lidocaine significantly lowers maternal perceived pain during genetic amniocentesis.

Cited by 6 publications

References 8 publications

Efficacy of lidocaine local anesthesia on pain perception during amniocentesis: A meta-analysis of randomized controlled trials

Efficacy of lidocaine local anesthesia on pain perception during amniocentesis: A meta-analysis of randomized controlled trials

Cold therapy for pain relief during and after amniocentesis procedure: A randomized controlled trial

Effect of Xylocaine spray for analgesia during amniocentesis: a randomized controlled trial

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