Local Anesthetic Agents for Vitreoretinal Surgery

Jaichandran, VV; Raman, Rajiv; Gella, Laxmi; Sharma, Tarun

doi:10.1016/j.ophtha.2014.11.026

Cited by 28 publications

(24 citation statements)

References 10 publications

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“…Abovementioned differences ( [35,36]. Nevertheless, in selected subgroups of patients, intolerable pain perception during surgery negatively influenced patient satisfaction from the surgery in some reports [35; 37].…”

Section: Resultsmentioning

confidence: 99%

“…Jaichandran et al [35] observed the efficacy of PBB, expressed as adequate globe akinesia, to be 20-60%, depending on the LA mixture used; hence, on average, half of PBBs may theoretically provide insufficient analgesia. This is because estimation of sensory block by abolition of the corneal reflex may not always imply that there is no sensory perception of surgical manipulations.…”

Section: Postoperative Intolerable Pain Perception (Pipp)mentioning

confidence: 99%

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Effect of topical or peribulbar analgesia on the incidence of oculocardiac reflex, postoperative pain and postoperative nausea and vomiting following vitreoretinal surgery under surgical pleth index-guided general anaesthesia.

Stasiowski

Pluta

Lyssek-Boroń³

et al. 2019

Preprint

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Background: Despite of the risk of postoperative intolerable pain perception (PIPP), vitreoretinal surgery (VRS) requires general anaesthesia (GA) in selected patients. Intraoperative use of opioid analgesics (OA) during GA carries the risk of postoperative nausea and vomiting (PONV). The surgical pleth index (SPI) optimises the intraoperative titration of OA. Regional anaesthesia techniques are combined with GA to minimize the intraoperative use of OA. We evaluated the benefit of preventive analgesia techniques combined with GA using SPI-guided fentanyl (FNT) administration on the incidence of PONV, oculocardiac reflex (OCR) and PIPP in patients undergoing VRS. Methods: One hundred and five patients undergoing VRS were randomly allocated to receive either GA with SPI-guided fentanyl (FNT) administration alone (GA group) or with preventive topical 2% proparacaine (topical anaesthesia (TA) group) or preoperative peribulbar block (PBB) using 0.5% bupivacaine with 2% lidocaine (PBB group). Fifteen patients were excluded due to problems with postoperative SPI measurement. Results: Preventive PBB resulted in intraoperative reduction in FNT requirement, with no influence on perioperative outcomes. Intraoperative SPI-guided FNT administration during GA resulted in OCR in 7.78%, PONV in 10% and PIPP in 13.5% of patients undergoing VRS. Intraoperative SPI-guided FNT administration blunted the perioperative effect of preventive PBB and TA in terms of the presence of PONV, OCR and PIPP.Conclusions: The utility of SPI-guided FNT administration during GA eliminated benefits of preventive analgesia with PBB and TA following VRS. We recommend using intraoperative SPI-guided FNT administration during GA to reduce the presence of OCR, PONV and PIPP following VRS. Trial registration: The trial was approved and registered by The Ethical Committee of Medical University of Silesia on 29th of September 2015, as well as the project was registered in the Clinical Trial Registry (SilesianMUKOAiIT2, NCT02973581)Key words: vitreoretineal surgery, general anaesthesia, peribulbar block, topical anaesthesia, surgical pleth index.

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Section: Resultsmentioning

confidence: 99%

Section: Postoperative Intolerable Pain Perception (Pipp)mentioning

confidence: 99%

Effect of topical or peribulbar analgesia on the incidence of oculocardiac reflex, postoperative pain and postoperative nausea and vomiting following vitreoretinal surgery under surgical pleth index-guided general anaesthesia.

Stasiowski

Pluta

Lyssek-Boroń³

et al. 2019

Preprint

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“…Local anesthetics are generally used in clinical, medical and dental practices to reduce operative pain [1][2][3][4][5][6][7]and as co-adjuncts in postoperative analgesia [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Pissulin¹,

Fernandes

Orellana

et al. 2017

Journal of Photochemistry and Photobiology B: Biology

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“…These substances are widely used during medical and dental surgical procedures with the aim of achieving a safer and more comfortable procedure for patients [4][5][6][7][8][9][10], as well as the relief of postoperative pain. They are also used to treat chronic pain [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

GaAs laser therapy reestablishes the morphology of the NMJ and nAChRs after injury due to bupivacaine

Pissulin¹,

Castro

Codina

et al. 2017

Journal of Photochemistry and Photobiology B: Biology

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Local Anesthetic Agents for Vitreoretinal Surgery

Cited by 28 publications

References 10 publications

Effect of topical or peribulbar analgesia on the incidence of oculocardiac reflex, postoperative pain and postoperative nausea and vomiting following vitreoretinal surgery under surgical pleth index-guided general anaesthesia.

Effect of topical or peribulbar analgesia on the incidence of oculocardiac reflex, postoperative pain and postoperative nausea and vomiting following vitreoretinal surgery under surgical pleth index-guided general anaesthesia.

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

GaAs laser therapy reestablishes the morphology of the NMJ and nAChRs after injury due to bupivacaine

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