Local anesthetic intoxication of the fetus—a newly recognized complication of maternal caudal anesthesia

Sinclair, John C.; Fox, H.; Lentz, Joseph F.; Fuld, Gilbert L.; Murphy, Jerome

doi:10.1016/s0022-3476(65)82120-5

Cited by 10 publications

(9 citation statements)

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“…Les sept autres intoxications concernaient des injections périnéales de mépivacaïne dont six dans le scalp [14,15] et une injection sous cutanée périnéale sans lésion du scalp avec confirmation par dosage sanguin [13].…”

Section: Discussionunclassified

Intoxication néonatale à la lidocaïne après analgésie par bloc des nerfs honteux : à propos de trois observations

Pagès

Gastine²,

Quedru-Aboane

et al. 2008

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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Section: Discussionunclassified

Intoxication néonatale à la lidocaïne après analgésie par bloc des nerfs honteux : à propos de trois observations

Pagès

Gastine²,

Quedru-Aboane

et al. 2008

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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“…Intoxication of newborns by lidocaine given to the mother during delivery was first described by Sinclair and colleagues in 1965 3. Detailed clinical features including apnoea, hypotonia, seizures, and cardiac symptoms such as bradycardia or ventricular tachycardia were reported in 1991 4.…”

Section: Discussionmentioning

confidence: 99%

Perinatal asphyxia and inadvertent neonatal intoxication from local anaesthetics given to the mother during labour

Pignotti

Indolfi

Ciuti

et al. 2004

BMJ

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“…The bradycardia is responsive to epinephrine or isoproterenol administration, but not atropine. Other suggested methods of management include exchange transfusion, 5 diuresis and acidification of the urine, 12 and gastric lavage. 13…”

Section: Discussionmentioning

confidence: 99%

Lidocaine Toxicity After Maternal Pudendal Anesthesia in a Term Infant with Fetal Distress

Bozynski

Rubarth²,

Patel

1987

Amer J Perinatol

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There have been many reports of lidocaine toxicity especially after maternal paracervical block anesthesia. We recently treated a term infant with evidence of fetal distress who presented with symptoms of lidocaine toxicity after maternal pudendal anesthesia. The infant developed apnea and bradycardia soon after birth which responded to mechanical ventilation and epinephrine. A prolonged Q-T interval was noted on day 1 which normalized by day 3. Cord blood was assayed and revealed an elevated lidocaine level. Lidocaine toxicity has been associated with fetal distress secondary to fetal ion trapping in the presence of acidosis. Although good response to supportive therapy occurred in our patient, other methods of therapy such as exchange transfusion and treatment of seizures may be required in some cases. Awareness of this now uncommon syndrome will lead to prompt diagnosis, appropriate work-up, and management.

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Local anesthetic intoxication of the fetus—a newly recognized complication of maternal caudal anesthesia

Cited by 10 publications

References 0 publications

Intoxication néonatale à la lidocaïne après analgésie par bloc des nerfs honteux : à propos de trois observations

Intoxication néonatale à la lidocaïne après analgésie par bloc des nerfs honteux : à propos de trois observations

Perinatal asphyxia and inadvertent neonatal intoxication from local anaesthetics given to the mother during labour

Lidocaine Toxicity After Maternal Pudendal Anesthesia in a Term Infant with Fetal Distress

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