Local anti-inflammatory activity: Topical formulation containing Kalanchoe brasiliensis and Kalanchoe pinnata leaf aqueous extract

Araújo, Edilane Rodrigues Dantas de; Félix-Silva, Juliana; Xavier-Santos, Jacinthia Beatriz; Fernandes, Júlia Morais; Guerra, Gerlane Coellho Bernardo; Araújo, Aurigena Antunes de; Araújo, Daline Fernandes de Souza; Ferreira, Leandro de Santis; Silva-Júnior, Arnóbio Antônio da; Fernandes-Pedrosa, Matheus de Freitas; Zucolotto, Silvana Maria

doi:10.1016/j.biopha.2019.108721

Cited by 31 publications

(24 citation statements)

References 31 publications

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“…Another study was conducted on Swiss albino mice with induced edema. Two leaf extracts from Kalanchoe brasiliensis and Kalanchoe pinnata were administered topically and both of them had an inhibitory effect on myeloperoxidase activity, the levels of IL-1β, and TNF-α (pro-inflammatory cytokines) and increased the levels of IL-10 (anti-inflammatory) [59].…”

Section: Modulation Of Skin Immunity By Plant Extractsmentioning

confidence: 99%

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Sitarek

Merecz-Sadowska

Kowalczyk

et al. 2020

IJMS

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The skin is an important organ that acts as a physical barrier to the outer environment. It is rich in immune cells such as keratinocytes, Langerhans cells, mast cells, and T cells, which provide the first line of defense mechanisms against numerous pathogens by activating both the innate and adaptive response. Cutaneous immunological processes may be stimulated or suppressed by numerous plant extracts via their immunomodulatory properties. Several plants are rich in bioactive molecules; many of these exert antimicrobial, antiviral, and antifungal effects. The present study describes the impact of plant extracts on the modulation of skin immunity, and their antimicrobial effects against selected skin invaders. Plant products remain valuable counterparts to modern pharmaceuticals and may be used to alleviate numerous skin disorders, including infected wounds, herpes, and tineas.

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Section: Modulation Of Skin Immunity By Plant Extractsmentioning

confidence: 99%

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Sitarek

Merecz-Sadowska

Kowalczyk

et al. 2020

IJMS

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“…The anti-inflammatory activity of Bryophyllum extracts has been determined by different methods using both in vivo and in vitro models. For instance, aqueous extracts from B. pinnatum were shown to exert a relevant effect against croton oil-induced ear edema and carrageenan-induced paw edema in murine models, driven by a decrease in pro-inflammatory cytokines [57]. Moreover, different flavonoids produced by B. tubiflorum showed an inhibitory effect on nitric oxide production by lipopolysaccharide-induced macrophage in vitro RAW264.7 cell line [58].…”

Section: Species Ethnobotanical Uses Plant Organ Locationsmentioning

confidence: 99%

From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp.

et al. 2020

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The subgenus Bryophyllum includes about 25 plant species native to Madagascar, and is widely used in traditional medicine worldwide. Different formulations from Bryophyllum have been employed for the treatment of several ailments, including infections, gynecological disorders, and chronic diseases, such as diabetes, neurological and neoplastic diseases. Two major families of secondary metabolites have been reported as responsible for these bioactivities: phenolic compounds and bufadienolides. These compounds are found in limited amounts in plants because they are biosynthesized in response to different biotic and abiotic stresses. Therefore, novel approaches should be undertaken with the aim of achieving the phytochemical valorization of Bryophyllum sp., allowing a sustainable production that prevents from a massive exploitation of wild plant resources. This review focuses on the study of phytoconstituents reported on Bryophyllum sp.; the application of plant tissue culture methodology as a reliable tool for the valorization of bioactive compounds; and the application of machine learning technology to model and optimize the full phytochemical potential of Bryophyllum sp. As a result, Bryophyllum species can be considered as a promising source of plant bioactive compounds, with enormous antioxidant and anticancer potential, which could be used for their large-scale biotechnological exploitation in cosmetic, food, and pharmaceutical industries.

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“…), Crassulaceae family, popularly known as “ saião ” and “ coirama ”, is widely used in traditional medicine worldwide, mainly in treating inflammatory, gastritis, and ulcer problems ( The Plant List, 2010 ; Fernandes et al, 2019 ). B. pinnatum is rich in phenolic compounds, especially quercetin- and kaempferol-derived flavonoid glycosides, which are responsible for some of these aforementioned biological activities, and other secondary metabolites such as terpenes, steroids, and bufadienolides ( Muzitano et al, 2006 ; Cruz et al, 2012 ; Fernandes et al, 2016 ; de Araújo et al, 2019 ). In acute toxicity studies (14 days; using albino Swiss and BALB/c mice) with ethanolic and aqueous B. pinnatum extracts (administered orally) conducted as per Organization for Economic Co-operation and Development (OECD) guidelines, no mortality, noticeable behavioral, or biochemistry analysis changes were observed in any of the tested groups.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

et al. 2020

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pro-inflammatory and oxidative mediators, chemokines, and cell adhesion molecules. This immunomodulatory property was proposed that one of the possible action mechanisms of extract. An improvement in intestinal damage was also associated with a reduction in oxidative stress and infiltration of leukocytes, as evidenced by the reduction in malonaldialdehyde and myeloperoxidase activity and increase in total glutathione in the colonic tissue. Moreover, the extract improved the cytoarchitecture of the colonic tissue and the integrity of the intestinal epithelial barrier by restoring the expression of the proteins associated with mucosa protection. In view of the beneficial effects showed by the B. pinnatum leaf extract in preclinical rodent models of colitis there is the potential to conduct some future clinical studies to ensure safe and effective development of a phytotherapeutic treatment for human inflammatory bowel diseases.

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Local anti-inflammatory activity: Topical formulation containing Kalanchoe brasiliensis and Kalanchoe pinnata leaf aqueous extract

Cited by 31 publications

References 31 publications

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp.

Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

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