Local antibody formation in the brain of chickens

Zakay‐Rones, Zichria; Spira, Gad; Levy, Rachel

doi:10.1007/bf01249693

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1978

2010

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Cited by 4 publications

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“…The extent of the secretory immunc response elicited dcpends on the route of immunization. In order to evoke a local response, antigen should be applied to the site [16,18,19,21]. The parenteral route of immunization leads to humoral immunity only.…”

Section: Introductionmentioning

confidence: 99%

Modulation of the lung local immune response by systemic immunization

Zakay‐Rones

Hadas

Levy

1978

Med Microbiol Immunol

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The present study describes the respiratory immune response of mice to locally administered antigen, and the modulation of this response by systemic immunization. Intranasal immunization of mice with the A/PR/8/34 strain of influenza virus evoked local antibody response of the IgA type. The titer of the IgA antibodies declined to a nondetectable level in 40--50 days. If at that time a second intranasal dose was administered, a secondary IgA response was evoked. On the other hand, administration by the intramuscular route resulted in a mixed population of IgA and IgG antibodies. The relevance of this finding to problems of immunization against respiratory viral infections is discussed.

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Section: Introductionmentioning

confidence: 99%