Local application of rhTGF-β2 enhances peri-implant bone volume and bone-implant contact in a rat model

Ranieri, Aladino De; Virdi, Amarjit S.; Kuroda, Shinji; Shott, Susan; Leven, Robert M.; Hallab, Nadim J.; Sumner, Dale R.

doi:10.1016/j.bone.2005.03.011

Cited by 48 publications

(45 citation statements)

References 23 publications

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“…A number of studies have been carried out to overcome this issue, including the use of growth factors or drugs such as bisphosphonate [19][20][21][22][23][24]. However, these modalities are still unpopular because they have associated problems such as price, efficacy or safety.…”

Section: Discussionmentioning

confidence: 99%

The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

et al. 2010

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Section: Discussionmentioning

confidence: 99%

The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

et al. 2010

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“…In addition, systemic administration of TGF-β2 increased the rate of bone formation and mineral apposition 38) . Using implantation experiments into the rat femur bone defects, Ranieri et al 25) studied the influence of loading TGF-β2 to hydroxyapatite/tricalcium phosphate coated titanium implants on bone response, and reported that 10 μg rhTGF-β2 loading increased bone regeneration, but a lower dose was not effective. In contrast, Sena et al 26) evaluated the doses of rhTGF-β2 at 5, 10 and 20 μg for bone response after implantation into rat femur defects and found that all rhTGF-β2 groups provided significantly higher bone volume.…”

Section: Discussionmentioning

confidence: 99%

“…Ranieri et al 25) and Sena et al 26) loaded TGF-β2 onto hydroxyapatite/tricalcium phosphate coated titanium implants and placed the implants into rat femur defects. Loaded TGF-β2 stimulated bone formation around the dental implants and increased implant fixation strength.…”

Section: Introductionmentioning

confidence: 99%

Bone response of TGF-β2 immobilized titanium in a rat model

Suzuki

Hayakawa

Kawamoto³

et al. 2014

Dent. Mater. J.

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The present study aimed to immobilize TGF-β2 onto titanium implants by using a tresyl chloride-activation technique and to evaluate the bone response of TGF-β2 immobilized titanium (TGF-β2/Ti) implants in a rat femur defect model. XPS and FT-IR measurements identified the presence of TGF-β2 on titanium. Atomic force microscopy showed globular images of immobilized TGF-β2. The contact angle of TGF-β2/Ti against water significantly decreased compared with untreated titanium (Ti). There was no change of surface roughness after immobilization of TGF-β2. Ti and TGF-β2/Ti implants were inserted into rat femur defects. TGF-β2/Ti showed more bone formation by calcein labeling and histological observation. The measurements of bone to implant contact (BIC) and bone mass (BM) around the implants revealed that BIC and BM of TGF-β2/Ti implants were significantly higher than those of Ti at 4 weeks after the implantation. In conclusion, TGF-β2/Ti implant effectively enhances bone regeneration around implants.

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“…Transforming growth factor beta-1 (TGF-beta 1), which is highly chemotactic toward osteoblasts, and TGF-beta 2 may enhance bone healing at lower concentrations (Lind, 1998;De Ranieri et al, 2005), but human clinical trials are lacking.…”

Section: Biomolecules In Regenerationmentioning

confidence: 99%

The Role of Heparan Sulfate and Perlecan in Bone-regenerative Procedures

DeCarlo

Whitelock

2006

J Dent Res

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Tissue engineering, grafting procedures, regeneration, and tissue remodeling are developing therapeutic modalities with great potential medical value, but these regenerative modalities are not as effective or predictable as clinicians and patients would like. Greater understanding of growth factors, cytokines, extracellular matrix molecules, and their roles in cell-mediated healing processes have made these regenerative therapies more clinically viable and will continue advancing the fields of tissue engineering and grafting. However, millions of oral and non-oral bone-grafting procedures are performed annually, and only a small percentage yield the most desirable results. Here we review the heparan-sulfate-decorated extracellular biomolecule named perlecan and the research relating to its potential as an adjunct in bone-regenerative procedures. The review includes an overview of bone graft substitutes and biological adjuncts to bone-regenerative procedures in medicine as they apply to periodontal disease, alveolar ridge augmentation, and barrier membrane therapy. Perlecan is discussed as a potential biological adjunct in terms of growth factor sequestration and delivery, and promoting cell adhesion, proliferation, differentiation, and angiogenesis. Further, we propose delivery and application schemes for perlecan and/or its domains in bone-regenerative procedures, with particular emphasis on its heparan-sulfate-decorated domain I. The perlecan molecule, with its heparan sulfate glycosylation, may provide a multi-faceted approach for the delivery of a more comprehensive stimulus than other single potential adjuncts currently available for bone-regenerative procedures.

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Local application of rhTGF-β2 enhances peri-implant bone volume and bone-implant contact in a rat model

Cited by 48 publications

References 23 publications

The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

Bone response of TGF-β2 immobilized titanium in a rat model

The Role of Heparan Sulfate and Perlecan in Bone-regenerative Procedures

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