Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats

Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study

“…Our study also is in accordance with Ayukawa et al [28]. In their study they demonstrated the effect of the local administration of simvastatin on the healing of artificially created bone defects.…”

“…• Promotes early consolidation of the graft [24][25][26][27] • Hastens the mineralization of the graft [28,29].…”

Dental Implant Surface Enhancement and Osseointegration

“…Simvastatin given per-orally to adult rats increased cancellous bone mass and increased cancellous bone compressive strength (Oxlund et al, 2001). Ayukawa et al (2009) confirmed that topical application of statins to alveolar bone increased bone formation and concurrently suppressed osteoclast activity at the bone-healing site. In addition, clinical studies reported that statin use is associated with increased bone mineral density (Edwards et al, 2000, Montagnani et al, 2003.…”

Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel

“…Statins are widely used to lower cholesterol levels, which is an important factor in the treatment of hyperlipidemia and arteriosclerosis. Recently, another in vivo effect of statins has also attracted attention, with a number of studies finding that statins promote differentiation of osteoblasts produced by stimulation with bone morphogenetic protein-2 (BMP-2) [2][3][4][5][6][7] , indicating their potential in the development of new osteogenic drugs. Statins are expected as a new treatment modality for bone diseases instead of BMP-2, because they can be easily synthesized and be made 16,000-times cheaper to produce than BMP-2 2) .…”

“…However, a major hurdle in the clinical application of statins is finding an appropriate method of local administration. When administered by injection their effect has been reported to be lost within 5 days 7) , making this modality impractical for clinical application in bone healing. Therefore, various methods of local administration, or drug delivery system (DDS), have been explored, and include the use of collagen gel, polyethylene glycol, and polylactide-co-glycolide [8][9][10] .…”