Local co-delivery of 5-fluorouracil and curcumin using Schiff's base cross-linked injectable hydrogels for colorectal cancer combination therapy

Abandansari, Hamid Sadeghi; Pakian, Sarvenaz; Nabid, Mohammad Reza; Ebrahimi, Marzieh; Rezalotfi, Alaleh

doi:10.1016/j.eurpolymj.2021.110646

Cited by 37 publications

(24 citation statements)

References 44 publications

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“…As a consequence of the anatomical position of CRC tumors, the continuous alterations of the physiological conditions and the constitution of tumors influence the therapeutic response [19]. Recently, an increased number of studies have investigated via in vitro and in vivo experiments various combinatorial chemotherapy regimens with compounds from different classes, i.e., statins, curcuminoids, or isothiocyanate [20][21][22], as means to enhance the cytotoxic effect of conventional chemotherapeutic drugs. Among these classes, statins were the only ones that were tested in clinical trials and provided an improved therapeutic response due to their pleiotropic effects, i.e., antiproliferative, anti-inflammatory, and antioxidant [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

A Screening Study for the Development of Simvastatin-Doxorubicin Liposomes, a Co-Formulation with Future Perspectives in Colon Cancer Therapy

et al. 2021

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An increasing number of studies published so far have evidenced the benefits of Simvastatin (SIM) and Doxorubicin (DOX) co-treatment in colorectal cancer. In view of this, the current study aimed to investigate the pharmaceutical development of liposomes co-encapsulating SIM and DOX, by implementing the Quality by Design (QbD) concept, as a means to enhance the antiproliferative effect of the co-formulation on C26 murine colon cancer cells co-cultured with macrophages. It is known that the quality profile of liposomes is dependent on the critical quality attributes (CQAs) of liposomes (drug entrapped concentration, encapsulation efficiency, size, zeta potential, and drug release profile), which are, in turn, directly influenced by various formulation factors and processing parameters. By using the design of experiments, it was possible to outline the increased variability of CQAs in relation to formulation factors and identify by means of statistical analysis the material attributes that are critical (phospholipids, DOX and SIM concentration) for the quality of the co-formulation. The in vitro studies performed on a murine colon cancer cell line highlighted the importance of delivering the optimal drug ratio at the target site, since the balance antiproliferative vs. pro-proliferative effects can easily be shifted when the molar ratio between DOX and SIM changes.

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Section: Introductionmentioning

confidence: 99%

A Screening Study for the Development of Simvastatin-Doxorubicin Liposomes, a Co-Formulation with Future Perspectives in Colon Cancer Therapy

et al. 2021

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“…32 Ma et al prepared a hybrid system joining the injectable hydrogels and microspheres by combining poly(DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA−PEG−PLGA) hydrogels with alginate microspheres deprived of consuming any organic solvent or surfactant. 33 In this study and in continuation of our previous study, 28 initially, we encapsulated 5-FU into polymeric microgels, and then the microgels were incorporated the into hydrogel network to delay 5-FU release. The microgels were synthesized based on poly(acrylic acid) and poly(N-isopropylacrylamide) (PNIPAm-co-AA).…”

Section: Introductionmentioning

confidence: 82%

“…Hydrazide functionalization of gelatin was conducted following methods described by Kageyama et al 35 using BtOH/ EDC chemistry based on the formulations given in our previous work. 28 2.6. Synthesis of Aldehyde-Functionalized Pluronic F127 (PF127-CHO).…”

Section: Synthesis Of Adipic Acid Dihydrazide (Adh)mentioning

confidence: 99%

“…The details of the synthesis procedure have been described in our previous work. 28 2.7. Preparation of Curcumin Loaded PF127-CHO Micelles.…”

Section: Synthesis Of Adipic Acid Dihydrazide (Adh)mentioning

confidence: 99%

“…During the process of preparing the hydrogel, the 5-FU was loaded into the network. 28 The results showed the burst release of 5-FU (more than 60%) in the initial hours (during 5 h) which is a common problem for delivery of hydrophilic drugs using hydrogels. To overcome this challenge, several soft nanocomposite systems, known as "plum pudding" hydrogels, are investigate to regulate the drug or growth factor release by entrapment of nanoscopic or microscopic structures within hydrogels.…”

Section: Introductionmentioning

confidence: 96%

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Gelatin-Based Injectable Hydrogel/Microgel Composite as a Combinational Dual Drug Delivery System for Local Co-delivery of Curcumin and 5-Fluorouracil in Synergistic Therapy of Colorectal Cancer

Pakian

Radmanesh

Abandansari

et al. 2022

ACS Appl. Polym. Mater.

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Chemotherapy using curcumin (Cur) and 5-fluorouracil (5-FU) has been broadly applied to treat colorectal cancer (CRC). In situ chemotherapy mediated by biological macromolecule platforms, such as gelatin-based injectable hydrogels, has recently attracted sizable attention due to their injectability, biocompatibility, and high therapeutic efficacy. Here, a microgel-embedded and micelle-cross-linked injectable hydrogel composite (MMHC) was synthesized for combinational local delivery of 5-FU and curcumin. The hydrophobic core of Pluronic-based micelles in injectable hydrogel was prepared for loading curcumin as a hydrophobic drug. The microgels were physically entrapped into the injectable hydrogel for sustained hydrophilic drug delivery. 5-FU release could be sustained for more than a month from these composite hydrogels, which is considerably longer than that achievable using the microgels alone. The proliferation inhibitory effect and cell cycle arrest were observed in HT-29 cells using the dual drug loaded MMHC system. In conclusion, the Cur/5-FU@MMHC system is a synergistic therapeutic delivery system that can achieve prolonged, sustained-release action for the combination of 5-FU and curcumin against the human colon cancer cell line HT-29.

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An Injectable Living Hydrogel with Embedded Probiotics as a Novel Strategy for Combating Multifaceted Pathogen Wound Infections

Tao,

Zhang,

Wei

et al. 2024

Adv Healthcare Materials

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Wound infections pose a significant challenge in healthcare, and traditional antibiotic treatments often result in the development of resistant pathogens. Addressing this gap, we introduced ProGel, a living hydrogel created by entrapping probiotic Lactobacillus plantarum as a therapeutic component within a gelatin matrix. With a double‐syringe system, ProGel can be easily mixed and applied, conforming swiftly to any wound shape and forming hydrogel in situ. It also demonstrated robust mechanical and self‐healing properties owing to the Schiff‐base bonds. ProGel sustained more than 80% viability of the entrapped L. plantarum while restricting their escape from the hydrogel. After a week of storage, more than 70% viability of the entrapped L. plantarum was preserved. Importantly, ProGel exhibited broad‐spectrum antimicrobial efficacy against pathogens commonly associated with wound infections, i.e., Pseudomonas aeruginosa (7Log reduction), Staphylococcus aureus (3‐7Log reduction), and Candida albicans (40‐70% reduction). Moreover, its cytocompatibility was affirmed through co‐culture with human dermal fibroblasts. The effectiveness of ProGel was further highlighted in more clinically relevant tests on human skin wound models infected with P. aeruginosa and S. aureus, where it successfully prevented the biofilm formation of these pathogens. This study showcases an injectable living hydrogel system for the management of complex wound infections.This article is protected by copyright. All rights reserved

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Local co-delivery of 5-fluorouracil and curcumin using Schiff's base cross-linked injectable hydrogels for colorectal cancer combination therapy

Cited by 37 publications

References 44 publications

A Screening Study for the Development of Simvastatin-Doxorubicin Liposomes, a Co-Formulation with Future Perspectives in Colon Cancer Therapy

A Screening Study for the Development of Simvastatin-Doxorubicin Liposomes, a Co-Formulation with Future Perspectives in Colon Cancer Therapy

Gelatin-Based Injectable Hydrogel/Microgel Composite as a Combinational Dual Drug Delivery System for Local Co-delivery of Curcumin and 5-Fluorouracil in Synergistic Therapy of Colorectal Cancer

An Injectable Living Hydrogel with Embedded Probiotics as a Novel Strategy for Combating Multifaceted Pathogen Wound Infections

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