INTRODUCTIONErysipelas also called bacterial dermo-hypodermitis is an infection of deep skin layers, mainly due to streptococcus [1,2]. Facial localization became become less frequent while the infection is currently developed on the leg [3,4]. Erysipelas of the leg is a common skin infection in dermatology consultation in sub-Saharan Africa [5][6][7][8]. However monocentric studies are rather conducted in these areas instead of multicentric type studies. We aimed at describing the epidemiological and clinical characteristics of erysipelas of the leg, and ABSTRACT Introduction: Erysipelas of the leg is a common and serious infection. We carried out this study aiming at describing the epidemiological and clinical characteristics, and assessing the risks factors associated with the local complications of erysipelas of the leg in sub-Saharan Africa. Methods: This was a prospective multicentric study carried out in the dermatology units of Hospitals located in seven sub-Saharan African countries during a period of 12 months. Patients aged 15 and above with a first episode of erysipelas of the leg were recruited. Results: In this study, 562 patients were recruited, having a mean age of 43.7±16.9 years and a sex-ratio (M/F) of 0.67. Patients infected on one leg were 562 while those infected with two were 27. Bullous forms of the disease were observed in 95 patients, while purpuric forms were observed in 167 patients. The existence of a point of entry (485 cases), obesity (230), lymph edema (130) and the use of bleaching agents (97) were the mains risk factors. Complications during the course of the infection such as necrotizing fasciitis (34 cases) and abscesses (63 cases) were observed. They were due to the use of antibiotics and non-steroidal anti-inflammatory treatments, and the use of cataplasm. Conclusion: This study reveals that existence of a point of entry, obesity and lymph edema, and the use of bleaching agents were the mains risk factors influencing the local complications of erysipelas of the leg. Necrotizing fasciitis and abscesses were influenced by the use of antibiotics and non-steroidal anti-inflammatory treatments, and the use of cataplasm.