Local control and survival in spinal cord compression from lymphoma and myeloma

Wallington, Margaret; Mendis, Shehara; Premawardhana, U.; Sanders, Prashanthan; Shahsavar-Haghighi, K.

doi:10.1016/s0167-8140(96)01858-0

Cited by 51 publications

(25 citation statements)

References 18 publications

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“…Chemotherapy may be administered in addition to radiotherapy if MESCC is caused by chemo sensitive tumors such as hematological or germcell malignancies. [68][69][70] In a series of 48 lymphoma patients who received either radiotherapy alone, chemotherapy alone or both regimens, the 10year local control rates were 50%, 46% and 76%, respectively. 68 In another series of 48 patients withlymphoma or myeloma, no further progression of neurologic symptoms was observed in 58% of patients after radiotherapy alone and in 75% of patients after radiotherapy plus chemotherapy.…”

Section: Glucocorticoid Therapymentioning

confidence: 99%

The role of radiotherapy for metastatic epidural spinal cord compression

2010

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Radiotherapy alone is the most common treatment for metastatic epidural spinal cord compression (MESCC). Decompressive surgery followed by radiotherapy is generally indicated only in 10-15% of MESCC cases. Chemotherapy has an unclear role and may be considered for selected patients with hematological or germ-cell malignancies. If radiotherapy alone is given, it is important to select the appropriate regimen. Similar functional outcomes can be achieved with short-course radiotherapy regimens and longer-course radiotherapy regimens. Longer-course radiotherapy is associated with better local control of MESCC than short-course radiotherapy. Patients with a more favorable survival prognosis (expected survival of ≥6 months) should receive longer-course radiotherapy, as they may live long enough to develop a recurrence of MESCC. Patients with an expected survival of <6 months should be considered for short-course radiotherapy. A recurrence of MESCC in the previously irradiated region after short-course radiotherapy may be treated with another short-course of radiotherapy. After primary administration of longer-course radiotherapy, decompressive surgery should be performed if indicated. Alternatively, re-irradiation can be performed using high-precision techniques to reduce the cumulative dose received by the spinal cord. Larger prospective trials are required to better define the appropriate treatment for the individual patient.

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Section: Glucocorticoid Therapymentioning

confidence: 99%

The role of radiotherapy for metastatic epidural spinal cord compression

2010

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“…No significant differences could be observed for gender, distribution of favorable (myeloma, lymphoma, breast cancer) or unfavorable (cancer of unknown primary, lung cancer) tumors [5,16,27,30], pre-treatment ambulatory rates, and the time of developing motor deficits before radiotherapy. The two groups were also comparably balanced for age, performance status, and pre-treatment functional score (Table 1).…”

Section: Methodsmentioning

confidence: 88%

A Comparison of Two Different Radiation Schedules for Metastatic Spinal Cord Compression Considering a New Prognostic Factor

Rades

Karstens

2002

Strahlentherapie und Onkologie

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“…About 3 months after RT, 40 patients had to be excluded from follow-up (cancer-related deaths 31, insufficient data 9). Tables 1 and 2 show that the groups A (1–7 days), B (8–14 days), and C (>14 days) were comparably balanced for radiation parameters, for ambulatory status before RT, and for distribution of primary tumors including the distribution of favorable (breast cancer, myeloma, lymphoma) and unfavorable (lung cancer, cancer of unknown primary) tumors [2, 3, 5, 14]. …”

Section: Resultsmentioning

confidence: 99%

Time of Developing Motor Deficits before Radiotherapy as a New and Relevant Prognostic Factor in Metastatic Spinal Cord Compression: Final Results of a Retrospective Analysis

et al. 2001

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The aim of this retrospective analysis was to determine the prognostic value of the time of developing motor deficits before radiotherapy (RT) and to confirm our preliminary results by achieving statistical significance. Of 529 patients receiving spinal irradiation (1994–1998) 131 fulfilled the selection criteria. Three groups were formed according to time of developing motor deficits: 1–7 days (n = 51), 8–14 days (40), >14 days (40). Motor function was graded before, 2 weeks and 3 months after RT. After 2 weeks, patients developing motor deficits for >14 days showed improvement more often than patients of the other groups (65 versus 32.5 and 4%, p < 0.001). After 3 months results were comparable (p < 0.001). A slower development of motor deficits predicts a better functional outcome. Time of developing motor deficits before RT is a relevant prognostic factor in metastatic spinal cord compression.

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Local control and survival in spinal cord compression from lymphoma and myeloma

Cited by 51 publications

References 18 publications

The role of radiotherapy for metastatic epidural spinal cord compression

The role of radiotherapy for metastatic epidural spinal cord compression

A Comparison of Two Different Radiation Schedules for Metastatic Spinal Cord Compression Considering a New Prognostic Factor

Time of Developing Motor Deficits before Radiotherapy as a New and Relevant Prognostic Factor in Metastatic Spinal Cord Compression: Final Results of a Retrospective Analysis

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