Local Control of Piriform Sinus Cancer Treated by Radiation Therapy Alone

Itami, Jun; Umemura, Takashi; Aruga, Moriyo; Ode, Shigeomi

doi:10.3109/02841869709001285

Cited by 2 publications

(4 citation statements)

References 16 publications

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“…However, like other head and neck cancers, the incidence has been increasing over the past three decades, trailing the curve for tobacco and alcohol abuse (1)(2)(3)(4). The prognosis for hypopharyngeal cancer has generally been reported as being remarkably poor (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) and hypopharyngeal cancers seem to behave much more aggressively than the laryngeal cancers of similar aetiology and histology that originate just adjacent to the hypopharynx. Many reported series have concentrated on the treatment outcome for the relatively favourable group of small-stage operable patients (3,4,9,17), whereas the majority of patients are at an advanced stage of disease at the time of diagnosis.…”

Section: Original Articlementioning

confidence: 99%

“…Many reported series have concentrated on the treatment outcome for the relatively favourable group of small-stage operable patients (3,4,9,17), whereas the majority of patients are at an advanced stage of disease at the time of diagnosis. These advanced cases have been managed by radical radiotherapy (10,16,18,19) or combined treatment (5, 7, 11-14, 17, 20). Organ-conserving surgery is difficult (9), except when the primary lesion is small and suitable for endoscopic resection (17), and in these cases irradiated patients also do relatively well (18).…”

Section: Original Articlementioning

confidence: 99%

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Hypopharyngeal Squamous Cell Carcinoma: Treatment Results in 138 Consecutively Admitted Patients

Johansen

Grau²,

Overgaard³

2000

Acta Oncologica

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The aim of this study was to evaluate the results of the initial and salvage treatment for hypopharyngeal carcinoma. The study was conducted in 1963 to 1991 and included 138 patients (38 females (28%) and 100 males (73%)). Most of the tumours originated in the piriform sinus (86%). Tumour stage distribution was T1: 20%, T2: 27%, T3: 37% and T4: 17% and nodal stage distribution was N0: 45%, N1: 25%, N2: 10%, and N3: 20%. Primary treatment was delivered with curative intent in 124 out of 138 cases (90%). Treatment failure was noted in 98 patients, with 55% recurrence in T-position, 39% in N-position, and 14% at distant metastases sites. Salvage surgery was successful in 9 out of 32 patients. The overall 5-year locoregional tumour control, cause-specific and overall survival rates were 20%, 25% and 19%, respectively. Univariate actuarial analysis showed that T- and N-stage, clinical stage, tumour size and well-differentiated tumours were significant prognostic parameters. A Cox multivariate analysis showed that only the T- and N-stages were independent prognostic factors. In conclusion, the prognosis for advanced hypopharyngeal carcinoma is extremely poor and the meagre results with conventional radiotherapy alone indicate that other treatment modalities should be introduced in the management of this disease.

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Section: Original Articlementioning

confidence: 99%

Section: Original Articlementioning

confidence: 99%

Hypopharyngeal Squamous Cell Carcinoma: Treatment Results in 138 Consecutively Admitted Patients

Johansen

Grau²,

Overgaard³

2000

Acta Oncologica

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“…Die Prognose dieser fortgeschrittenen Erkrankungen ist ernst. Die 5-Jahres-Ûberlebensraten werden zwischen 0 und 20 % angegeben [4,6,8,9].…”

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“…Aufgrund der geringeren Morbidita Èt und a Èhnlicher onkologischer Ergebnisse wird derzeit mehr und mehr die kombinierte Radiochemotherapie als prima Ère Therapie diskutiert [2, 4,8]. Die Indikation zu operativen Verfahren, die in der Regel mit einem Organverlust einhergehen, wird zunehmend strenger gestellt.…”

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Laryngo-Hypopharyngo-Ösophagektomie beimfortgeschrittenen Hypopharynxkarzinom - Ist dieser radikalchirurgische Eingriff heute noch gerechtfertigt? -

Bödeker¹,

Füchtmeier²,

Stehr³

et al. 2000

Zentralbl Chir

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Minimal invasive laser surgery with preservation of the organs is well established in the treatment of hypopharynx carcinoma. In cases of advanced tumors of the hypopharynx, which can not be managed by laser surgery, the combined radio-chemo therapy becomes the treatment of choice because of the low morbidity and the comparable results. The indication for an operative procedure, which means loss of larynx and oesophagus, is seen more and more restrictively. From 1993 to 1997 101 patients with advanced neoplasm of the hypopharynx or larynx (larynxcarcinoma T4; hypopharynx carcinoma T3-T4 with N > 2b) were treated in the Department of Otolaryngology of the University of Regensburg. 5 of these patients underwent a laryngohypopharyngoesophagectomy. Only patients with a severe dysfunction of the larynx (dyspnea, dysphagia, aspiration) were selected for this procedure. Postoperative complications were: one insufficiency of anastomosis with secondary bleeding and five pleura effusions. In all cases postoperative radiation began within six weeks after the operation. All patients were nourished orally when they were discharged from hospital. The mean follow up was 21 months. During this time none of the patients died. In one case pulmonary metastasis was found after 11 months. In another case a regional recurrence was diagnosed after 11 months and was removed by operation. No local recurrence was found at that time. This operative procedure can be done only in experienced and well trained medical centers. Furthermore excellent cooperation of the operating teams and strong regard to the selection criteria is obligatory.

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Local Control of Piriform Sinus Cancer Treated by Radiation Therapy Alone

Cited by 2 publications

References 16 publications

Hypopharyngeal Squamous Cell Carcinoma: Treatment Results in 138 Consecutively Admitted Patients

Hypopharyngeal Squamous Cell Carcinoma: Treatment Results in 138 Consecutively Admitted Patients

Laryngo-Hypopharyngo-Ösophagektomie beimfortgeschrittenen Hypopharynxkarzinom - Ist dieser radikalchirurgische Eingriff heute noch gerechtfertigt? -

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