Local delivery of proteins and the use of self-assembling peptides

Segers, Vincent F.M.; Lee, Richard T.

doi:10.1016/j.drudis.2007.05.003

Cited by 92 publications

(84 citation statements)

References 52 publications

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“…Self-assembling is a process that is mediated by non-covalent interaction between molecules via ionic bonds, hydrogen bonding, hydrophobic interactions and van der Waal interactions [60]. Self-assembling peptides are normally 8-16 amino acids long and they are composed of alternating hydrophilic and hydrophobic residues that form a stable hydrogel of flexible nanofibers (NFs) upon exposure to physiological salt concentration or pH [61].…”

Section: Hydrogels In Cell-based Therapiesmentioning

confidence: 99%

Heart regeneration after myocardial infarction using synthetic biomaterials

Pascual-Gil

Garbayo

Díaz-Herráez

et al. 2015

Journal of Controlled Release

122

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Abstract:Myocardial infarction causes almost 7.3 million deaths each year worldwide. However, current treatments are more palliative than curative. Presently, cell and protein therapies are considered the most promising alternative treatments. Clinical trials performed until now have demonstrated that these therapies are limited by protein short half-life and by low transplanted cell survival rate, prompting the development of novel cell and protein delivery systems able to overcome such limitations. In this review we discuss the advances made in the last 10 years in the emerging field of cardiac repair using biomaterial-based delivery systems with focus on the progress made on preclinical in vivo studies. Then, we focus in cardiac tissue engineering approaches, and how the incorporation of both cells and proteins together into biomaterials has opened new horizons in the myocardial infarction treatment. Finally, the ongoing challenges and the perspectives for future work in cardiac tissue engineering will also be discussed.

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Section: Hydrogels In Cell-based Therapiesmentioning

confidence: 99%

Heart regeneration after myocardial infarction using synthetic biomaterials

Pascual-Gil

Garbayo

Díaz-Herráez

et al. 2015

Journal of Controlled Release

122

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“…It will also discuss a few areas of challenge and opportunity that exist as self-assembling biomaterials move closer to biotechnological and biomedical applications, including how these materials may interface with the immune system. For more detailed discussions of other aspects of self-assembling biomaterials, including stimulus-responsiveness, 2 protein delivery from self-assembled scaffolds, 3 polypeptide-based materials, 4, 5 biomaterials for controlling stem cell phenotype, 6 nanofibrous biomaterials, 5,7,8 peptide-amphiphiles, 8,9 and the cell-surface interface, 10 the reader is referred to other recent reviews. In addition, for more extensive discussions of modularity in supramolecular biomaterials, please see the comprehensive reviews published recently by Dankers and Meijer 11 and Weck and coworkers.…”

Section: Introductionmentioning

confidence: 99%

Modular self-assembling biomaterials for directing cellular responses

Collier

2008

Soft Matter

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Self-assembling biomaterials are promising as cell-interactive matrices because they can be constructed in a modular fashion, which enables the independent and simultaneous tuning of several of their physicochemical and biological properties. Such modularity facilitates the optimization of multi-component matrices for use in complex biological environments such as 3-D cell culture or scaffolds for regenerative medicine. This Highlight will discuss recent strategies for producing modular self-assembling biomaterials, with a particular focus on how ligand presentation and matrix mechanics can be controlled in modular ways. In addition, it will discuss key hurdles that remain for employing these materials as cell-interactive scaffolds in biomedical applications, particularly those that relate to how they may interface with the immune system.

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“…7 In recent years, these peptides have also been attracted great interest from scientists used for drug delivery system. [8][9][10] As we know, the self-assembly peptides lead to a unique amphiphilic structure because of numbers of hydrophobic and hydrophilic residues in the amino acid sequence. The property made them wide useful for combination with drug molecules.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Research of a Potential Carrier for Hydrophobic Compound Model Pyrene Using Amphiphilic Peptide EYK

Wang¹,

Zhao²

2011

Bulletin of the Korean Chemical Society

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In recent years, the study of self-assembly peptide used in drug delivery system has been attracted great interest from scientists. In the category are self-assembly peptides in the structure either with one hydrophobic surface and another hydrophilic or a hydrophobic head and a hydrophilic tail. Here, we focus on a novel designed peptide EYK with double amphiphilic surfaces, investigating on the capability of peptide as a carrier for hydrophobic compound model pyrene. The fluorescence data presented the dynamic process of the transfer, showing that the pyrene was in the crystalline form in peptide solution, and molecularly migrated from its peptide encapsulations into the membrane bilayers when the peptide-pyrene suspension was mixed with liposome vesicles. The results indicated that the peptide EYK could stabilize hydrophobic pyrene in aqueous solution and delivered it into EPC liposome as a potential carrier.

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Local delivery of proteins and the use of self-assembling peptides

Cited by 92 publications

References 52 publications

Heart regeneration after myocardial infarction using synthetic biomaterials

Heart regeneration after myocardial infarction using synthetic biomaterials

Modular self-assembling biomaterials for directing cellular responses

Dynamic Research of a Potential Carrier for Hydrophobic Compound Model Pyrene Using Amphiphilic Peptide EYK

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