2015
DOI: 10.2106/jbjs.n.00840
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Local Delivery of the Cationic Steroid Antibiotic CSA-90 Enables Osseous Union in a Rat Open Fracture Model of Staphylococcus aureus Infection

Abstract: Local delivery of CSA-90 represents a novel strategy for prevention of infection and may have specific benefits in the context of orthopaedic injuries.

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Cited by 26 publications
(34 citation statements)
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“…As mimics of AMPs, ceragenins display broad-spectrum antibacterial activity, including potent antibiofilm activity (1113). In in vivo studies involving medical devices and bone regrowth, ceragenins are effective in eliminating bacterial challenges, and local administration is well tolerated (1416). …”
Section: Textmentioning
confidence: 99%
“…As mimics of AMPs, ceragenins display broad-spectrum antibacterial activity, including potent antibiofilm activity (1113). In in vivo studies involving medical devices and bone regrowth, ceragenins are effective in eliminating bacterial challenges, and local administration is well tolerated (1416). …”
Section: Textmentioning
confidence: 99%
“…The mass of the sponge made the size of the SAIB depot and the collagen implant differ; however, the total dose of BMP‐2 added to both groups as well as the delivery volumes of the SAIB and the saline used to load the collagen sponge were comparable. For ethical and practical reasons, exhaustive internal controls for tissue histology were not performed, and specimens were compared to historical collagen/BMP‐2 treated fractures as previously published . The overall histological appearance of the collagen/BMP‐2 and SAIB/BMP‐2 and SAIB/BMP‐2/HA/ZA groups were analogous, and in addition the delayed/non‐unions in the SAIB group were akin to untreated open fractures also showing delayed union …”
Section: Discussionmentioning
confidence: 99%
“…In the case of plate osteosynthesis, woven bone deposition is more evident in bone regions distant to the implant‐related infection, that is, opposite or further away from the plate . In the case of intramedullary fixation, bone apposition is observed in the periosteal region along the length of the implant . Studies that have incorporated micro‐CT algorithms to quantify bone formation and bone destruction separately from each other, have confirmed that significantly enhanced bone volume is measured more peripheral to the infected site …”
Section: What Is the Balance Between The Osteoclastic And Osteoblastimentioning
confidence: 99%