Local disease control after stereotactic body radiotherapy in patients with neuroendocrine neoplasms: a cohort study

Insulin-producing pancreatic tumors are a common subtype of neuroendocrine tumor. Standard of care includes surgical resection of the pancreatic tumor and medical management with somatostatin analogs. For patients with metastatic disease, tumor control and hypoglycemic symptom relief can be achieved through surgical resection of the tumor, hepatic artery embolization, radiofrequency ablation, or radioembolization using radioactive isotopes as well as with systemic therapy such as somatostatin analogs and everolimus. We present the case of a 74-year-old male with metastatic insulin-producing pancreatic carcinoma. After a long history of successfully controlling his hypoglycemic episodes post-liver wedge resection, bland embolizations subsequently failed to maintain control of the frequency and severity of his hypoglycemic symptoms. Stereotactic body radiotherapy (SBRT) with protons was used to achieve symptomatic control and led to partial radiographic response with complete resolution of his hypoglycemic episodes. This case demonstrates the potential utility of proton SBRT in metastatic insulinomas.

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Gastroenteropancreatic neuroendocrine neoplasms: epidemiology, genetics, and treatment

Tan,

Zhang,

Chen

2024

Front. Endocrinol.

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The incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP NEN) is increasing at a rapid pace and is becoming an increasingly important consideration in clinical care. Epidemiological data from multiple countries indicate that the incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP NEN) exhibits regional, site-specific, and gender-based variations. While the genetics and pathogenesis of some GEP NEN, particularly pancreatic NENs, have been investigated, there are still many mechanisms that require further investigation. The management of GEP NEN is diverse, but surgery remains the primary option for most cases. Peptide receptor radionuclide therapy (PRRT) is an effective treatment, and several clinical trials are exploring the potential of immunotherapy and targeted therapy, as well as combination therapy.

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Local disease control after stereotactic body radiotherapy in patients with neuroendocrine neoplasms: a cohort study

Cited by 3 publications

References 23 publications

Current Status of Immunotherapy in Management of Small Bowel Neuroendocrine Tumors

Current Status of Immunotherapy in Management of Small Bowel Neuroendocrine Tumors

Proton Stereotactic Body Radiotherapy for Liver Metastases From Malignant Pancreatic Insulinoma

Gastroenteropancreatic neuroendocrine neoplasms: epidemiology, genetics, and treatment

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