Local drug delivery of folic acid promotes oral mucosal wound healing

Khan, Saif; Rahman, Syed Ziaur; Ahad, Abdul

doi:10.1016/j.jds.2020.07.001

Cited by 7 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study that wound healing process simulated by software analysisincreased cell proliferation was reported compared to the control group by almost 40% at the end of 48 h. In our previous study, cytocompatibility assays results showed folic acid-loaded hydrophilic fibers have no toxicity and neat folic acid improved cell generation by nearly 177 % [6]. It is contrary to the restriction of the utilization of folic acid in pure form, Pagano et al (2019) synthesized folic acid-based emulgels and MTT tests have indicated cell viability over 100 % [7].Furthermore, Zhao et al (2018) indicated folic acid can accelerate collagen formation in diabetic wounds [8].In a similar study, Khan et al asserted folic acid could be a potential candidate for the oral mucosal wound healing process [9]. Camacho et al (2019) createdcopper-alginate hydrogels containing folic acid.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Vitamin B9 - Electrosprayed Non-Woven Surfaces for Wound Healing Applications

Parın¹,

Yildirim²,

Taner³

et al. 2021

Eskişehir Technical University Journal of Science and Technology a - Applied Sciences and Engineering

View full text Add to dashboard Cite

In this study, novel wound dressing materials based on non-woven (NW) surfaces were developed using the electrospraying (e-spraying) process. Polyester spun-bond (PET SPB), polypropylene spun-bond (PP SPB), and polypropylene melt-blown (PP MB) surfaces used as matrix, and folic acid (FA), vitamin B9weresprayed on these surfaces. The resulting NW fabrics with the same FA content were investigated in terms of physical, morphological, thermal, wettability properties.Scanning Electron Microscopy and (SEM) and Fourier Transform Infrared (FT-IR) spectroscopy results showed the formation of physical interaction between NWs and FA.Notably, FA was successfully deposited onto NWs with average fiber diameters from 2.6 µm to 23.11 µm. According to the thermogravimetric analysis (TGA),FA loaded-PP SPB has enhanced thermal stability compared to pure one (PP SPB). The FA-loaded surfaces have a hydrophobic property with contact angles values more than >90°. The in-vitro release was carried out by UV-Vis within the 8 hour-period phosphate buffer saline (pH 7.2). The results indicated that FA-loaded surfaces have a fast release behaviour. The total FA release amounts of the FA-loaded PET SBP, PP SPB and PP MB NWs were found as 22.8, 17.1, and 17.5 ppm. Moreover, the biocompatibility of all resulting NW surfaces was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red uptake (NRU) cytotoxicity tests in L929 cell lines.The obtained NWs are biocompatible and non-toxic material, except PET SPB-sFA.The study indicated that FA-loaded NWs can be potential candidates for wound healing applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Vitamin B9 - Electrosprayed Non-Woven Surfaces for Wound Healing Applications

Parın¹,

Yildirim²,

Taner³

et al. 2021

Eskişehir Technical University Journal of Science and Technology a - Applied Sciences and Engineering

View full text Add to dashboard Cite

show abstract

Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections

Costa,

Nagay,

Villa

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Folate (FT) is a suitable targeting ligand for folate receptors (FOLR) overexpressed on inflamed cells. Thus, FT‐loaded polymers can be used as FOLRs‐targeted immunotherapy to positively modulate the inflammatory process. A novel biodegradable imprinted polymer with a FT delivery mechanism driven by pH changes [PCL‐MIP@FT] is designed with molecularly imprinted technology. The pH mechanism is validated in vitro, demonstrating that an acidic environment accelerated and increased the release of FT for a period of 7 days (∼100 µg mL−1). For the first time, FT receptors (FOLR‐1 and FOLR‐3) are discovered and also overexpressed on activated human gingival fibroblasts, representing a favorable target in the oral environment. Although FT itself does not have antimicrobial effects, the nanomechanical properties of biofilm are changed after topical FT administration. In vivo systemic toxicity of PCL‐MIP@FT has been demonstrated to be a safe biomaterial (up to 1.3 mg kg−1). When the PCL‐MIP@FT is assessed in the subcutaneous tissue, it promoted an alleviating inflammation and may be able to stimulate tissue repair. The present findings have demonstrated the reliable in vitro and in vivo anti‐inflammatory actions of FT‐loaded polymer and support its use as a novel drug‐free therapeutic platform for modulating and mitigating inflammatory responses in dental implant‐related infections.

show abstract

Tailoring the proliferation of fibroblast cells by multiresponsive and thermosensitive stem cells composite F127 hydrogel containing folic acid.MgO:ZnO/chitosan hybrid microparticles for skin regeneration

Rafie

Meshkini

2021

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Local drug delivery of folic acid promotes oral mucosal wound healing

Cited by 7 publications

References 10 publications

Development and Characterization of Vitamin B9 - Electrosprayed Non-Woven Surfaces for Wound Healing Applications

Development and Characterization of Vitamin B9 - Electrosprayed Non-Woven Surfaces for Wound Healing Applications

Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections

Tailoring the proliferation of fibroblast cells by multiresponsive and thermosensitive stem cells composite F127 hydrogel containing folic acid.MgO:ZnO/chitosan hybrid microparticles for skin regeneration

Contact Info

Product

Resources

About