Local Drug Delivery Systems as an Adjunct to Cure Periodontitis- The Novel Dental Applicant

Garg, Surbhi

doi:10.5530/phm.2015.6.1

Cited by 11 publications

(8 citation statements)

References 39 publications

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“…Periocline (Perio) is a clinical used formulation in the treatment of periodontitis, which contains 2% of minocycline hydrochloride in an emulsified regime containing a large amount of triacetine, glycerine, and other additives. 40 Although the organic portions may have a stimulative effect on the surrounding tissue, such a system could effectively reduce the diffusion rate of water-soluble compounds and thus lead to a prolonged period of cumulative release. Hence, a weekly dose is recommended in clinical applications.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for Periodontitis Treatment

Dong

Sun

Chen

et al. 2019

ACS Appl. Bio Mater.

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In this work, chitosan (CS) decorated metronidazole (MTZ) microcapsules (CS@MTZ) were synthesized and used as a cross-linker for the preparation of a poly(vinyl alcohol) (PVA) injectable hydrogel by dynamic covalent bonding and ionic interaction through a 4-carboxyphenylboronic acid bridge. The use of MTZ microcapsules efficiently slowed down the release rate of the hydrophilic antibiotic from the hydrogel matrix. Besides, the hydrophobicity of the microcapsules endows the PVA@CS@MTZ hydrogel to be sticky to a substrate in wet conditions, under a suggested mechanism of evicting the water boundary layer on the substrate. The sustained release behavior endowed a prolonged bacteriostasis ability of the hydrogel formulation for up to 14 days in vitro, and the bioadhesive property as well as the injectability of the hydrogel benefited the topical delivery of MTZ in periodontal pockets and exhibited desirable antibacterial capacity in 1 week on the rat periodontitis model.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for Periodontitis Treatment

Dong

Sun

Chen

et al. 2019

ACS Appl. Bio Mater.

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“…Failure in eradication of pathogenic microorganisms may lead to bacterial recolonization and treatment failure. [ 6 7 ]…”

Section: Introductionmentioning

confidence: 99%

“…However, the potential risks of superimposed infections, formation of resistant strains, and gastrointestinal disorders caused by long-term consumption of systemic antibiotics cannot be ignored. [ 6 8 9 ] Nowadays, local drug delivery (LDD) systems have become the focus of interest in recent years to solve these problems and optimize periodontal therapy.…”

Section: Introductionmentioning

confidence: 99%

Drug release kinetics and biological properties of a novel local drug carrier system

Shafiei

Ghavami-Lahiji

Kashi

et al. 2021

Dental Research Journal

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Background: The purpose of this in vitro study was to investigate drug release kinetics and cytotoxicity of a novel drug delivery system for treatment of periodontitis. Materials and Methods: This in vitro study addresses the fabrication of a polycaprolactone/alginic acid-based polymeric film loaded with metronidazole, as a basic drug in the treatment of periodontal diseases. Films were prepared by solvent casting technique. Four formulations with different percentages of drug by weight (3%, 5%, 9%, and 13%) were prepared. Drug release kinetics were investigated using ultraviolet–visible spectroscopy during (one week). Data were analyzed using repeated measures ANOVA. Cytotoxicity of drug-loaded system extracts was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using L929 cells after 24-h incubation. The results were evaluated according to ISO standard 10993-5 and assessed using ANOVA and Tukey's tests at a significance level of P < 0.05. Results: All polymeric films showed a burst drug release followed by a gradual release. Drug release data were fitted well with the first-order kinetic model in all drug-containing formulations indicating that drug release is a fraction of remaining drug in the matrix. Drug release is mainly driven by diffusion of medium into the composite matrix. 3%wt metronidazole-containing formulation exhibited the best MTT result. Conclusion: The findings of this study supported the synthesis of drug-loaded periodontal films with 3% metronidazole due to better biological properties along with the ability of acceptable drug release to eradicate anaerobic periodontal bacteria.

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“…Degradable scaffolds have the advantage that they only require a single visit for the insertion of the device. Various types of local drug delivery systems used in the treatment of periodontal diseases and peri-implant diseases include fibers, film, injectable systems, gels, strips, compacts, vesicular systems, microparticle systems, nanoparticle systems, and nanotube systems [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Controlled releasing properties of gelatin nanofabric device containing chlorhexidine

Dae-Ung

Chang

et al. 2021

Oral Biol Res

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We aimed to evaluate the degradation and antimicrobial activity of novel chlorhexidine-containing gelatin nanofabric devices and their cytotoxicity in animals. The electro-spun device with a size of 3×4×0.4 mm 3 was prepared by entrapping chlorhexidine gluconate (CHX) in a gelatin matrix. The devices were divided into three groups based on the CHX percentage (G1: 46%, G2: 50%, and G3: 54%), and the commercial product, PerioChip (CP), was used for the control group. We used an in vitro test for the degradation and antibacterial activity and investigated cytotoxicity using an in vivo test. Artificial saliva was used for the degradation test of chips and blood agar plates seeded with the oral bacteria Streptococcus sanguinis to address antibacterial activity. Furthermore, the devices were inserted between the skin and muscle of rat abdomens to evaluate infection and inflammatory reactions. We detected no obvious differences in the antibacterial or degradation test results between the test and control groups. In the histological analysis, the scaffold without CHX showed no signs of infection or inflammatory reaction. Both CHX-containing groups exhibited inflammation and necrosis in the muscle and skin, although the reaction in the test group was milder. In the degradation tests, antibacterial tests, and cytotoxic reactions in animal experiments, the electro-spun gelatin-based device showed similar results to those of the commercial device in the control group. Further studies on the quantitative analysis and clinical outcome evaluation of the electro-spun gelatin-based device in humans are necessary.

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Local Drug Delivery Systems as an Adjunct to Cure Periodontitis- The Novel Dental Applicant

Cited by 11 publications

References 39 publications

Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for Periodontitis Treatment

Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for Periodontitis Treatment

Drug release kinetics and biological properties of a novel local drug carrier system

Controlled releasing properties of gelatin nanofabric device containing chlorhexidine

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