Local Dynamics in Polypeptides Studied by Solid State 2H NMR: Side Chain Dynamics of Poly(γ-benzyl l-glutamate) and Racemic Poly(γ-benzyl glutamate)

Hiraoki, Toshifumi; Kitazawa, So; Tsutsumi, Atsushi

doi:10.1016/s0066-4103(04)53006-5

Cited by 3 publications

(1 citation statement)

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“…This field is, however, still of great interest for methodological reasons, as seen from the recent work by Cifelli et al [134]. 2 H and 14 N relaxation analysis were combined by Dong et al [135] to describe the head-group motion of an amphiphilic molecule in a lamellar phase, while chain reorientations and segmental motions in LLCs and PLCs were also studied by solid-state 13 C and 2 H NMR [136][137][138][139], dipolar recoupling 2D magicangle spinning (MAS) NMR [140], and 1 H double-quantum NMR techniques [141]. In a few cases, the analysis of 2 H NMR spin-spin relaxation times (T 2 ) was applied to the molecular reorientations of LCs or their moieties in the slow-motional limit [114,131,142,143], however, this technique has been most widely adopted to describe collective motions, as will be reported in the next subsection.…”

Section: Single-molecular Motionsmentioning

confidence: 99%

The role of NMR in the study of partially ordered materials: Perspectives and challenges

Domenici

2010

Pure and Applied Chemistry

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The development of NMR techniques applied in the last 10 years to partially oriented systems, and in particular to liquid crystals (LCs), is the object of this brief perspective. The evolution of NMR methods (i.e., new NMR pulse sequences) and the improvement of both theoretical models and mathematic tools for the analysis of NMR data (specifically, for partially ordered systems) allowed scientists to extend their research to increasingly complex materials, such as dendrimers, polymers, and membranes, and to investigate unique phenomena, such as field-induced alignment and confining effects. Furthermore, the fast development of nanoscience and biomedicine is offering a rich variety of new “physical chemical” problems related to partially ordered materials. Starting from a brief perspective of recent works on thermotropic and lyotropic LCs based on different NMR methods, new challenges in this field will be drawn. Moreover, recent selected research works will be discussed in detail with particular emphasis on: (i) the effect of high magnetic fields on the supramolecular structure of chiral liquid-crystalline phases, such as the SmC*, TGBA*, and “de Vries”-type SmA* phases, by means of solid-state 2H NMR; (ii) the slow dynamics in the isotropic phase of bent-core LCs (BLCs) and of liquid single-crystal elastomers evidenced by 2H NMR relaxation studies; and (iii) the influence of the LC environment on the conformational properties of rod-like mesogens studied by high-resolution solid-state 13C NMR methods. This work aims to offer an occasion of reflection on this field of physical chemistry with a glance at future trends and challenges in view of the celebration of the International Year of Chemistry, 2011. \ud \ud *Pure Appl. Chem. 83, 1–252 (2011). A collection of invited, peer-reviewed articles by former winners of the IUPAC Prize for Young Chemists, in celebration of the International Year of Chemistry 2011

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Section: Single-molecular Motionsmentioning

confidence: 99%

The role of NMR in the study of partially ordered materials: Perspectives and challenges

Domenici

2010

Pure and Applied Chemistry

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Local Dynamics in Polypeptides Studied by Solid State ²H NMR: Side Chain Dynamics of Poly(γ‐benzyl L‐glutamate) and Racemic Poly(γ‐benzyl Glutamate)

2005

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Nanoengineering Spikey Surfaces: Investigation of Reversible Organizational Control of Surface-Tethered Polypeptide Brushes

Huang,

Kim,

Padilla Salas

et al. 2024

Langmuir

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Nature serves as an important source of inspiration for the innovation and development of micro-and nanostructures for advanced functional surfaces and substrates. One example used in nature is a spikey surface ranging from micrometer-sized spikes on pollen grains down to the nanometer-scale protein spikes found on viruses. This study explored the realization of such highly textured surfaces via the nanoengineering of self-assembled poly(γbenzyl-L-glutamate) "nanospikes", exploiting solvent-induced chain organization, controlled surface chemical functionality, and enhanced stability in the form of polymer brushes. The reversible solvent-responsive behavior of these polymer chains and the aggregation behavior of the chain-ends were investigated via fluorescence characterization and studied through molecular simulations. Vapor-based solvent treatments were developed for orientation control with in situ analysis to understand film response and brush organizational behavior under different selected conditions. The effect of sub-100 nm nanopatterning on surface morphology and chain organization was examined via an integrated approach of experimental and computational studies. The methodologies established in this study present opportunities for engineering sophisticated nanoscale spikey surfaces with high customizability by means of nanolithography combined with solvent-assisted treatments.

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Local Dynamics in Polypeptides Studied by Solid State 2H NMR: Side Chain Dynamics of Poly(γ-benzyl l-glutamate) and Racemic Poly(γ-benzyl glutamate)

Cited by 3 publications

References 75 publications

The role of NMR in the study of partially ordered materials: Perspectives and challenges

The role of NMR in the study of partially ordered materials: Perspectives and challenges

Local Dynamics in Polypeptides Studied by Solid State ²H NMR: Side Chain Dynamics of Poly(γ‐benzyl L‐glutamate) and Racemic Poly(γ‐benzyl Glutamate)

Nanoengineering Spikey Surfaces: Investigation of Reversible Organizational Control of Surface-Tethered Polypeptide Brushes

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Local Dynamics in Polypeptides Studied by Solid State 2H NMR: Side Chain Dynamics of Poly(γ-benzyl l-glutamate) and Racemic Poly(γ-benzyl glutamate)

Cited by 3 publications

References 75 publications

The role of NMR in the study of partially ordered materials: Perspectives and challenges

The role of NMR in the study of partially ordered materials: Perspectives and challenges