The differential multiplicity of dileptons in a hot and magnetized quark-gluon plasma, ∆ B ≡ dN B /d 4 xd 4 q, is derived from first principles. The constant magnetic field B is assumed to be aligned in a fixed spatial direction. It is shown that the anisotropy induced by the B field is mainly reflected in the general structure of photon spectral density function. This is related to the imaginary part of the vacuum polarization tensor, Im[Π µν ], which is derived in a first order perturbative approximation. As expected, the final analytical expression for ∆ B includes a trace over the product of a photonic part, Im[Π µν ], and a leptonic part, L µν . It is shown that ∆ B consists of two parts, ∆ B and ∆ ⊥ B , arising from the components (µ, ν) = ( , ) and (µ, ν) = (⊥, ⊥) of Im[Π µν ] and L µν . Here, the transverse and longitudinal directions are defined with respect to the direction of the B field. Combining ∆ B and ∆ ⊥ B , a novel anisotropy factor ν B is introduced. Using the final analytical expression of ∆ B , the possible interplay between the temperature T and the magnetic field strength eB on the ratio ∆ B /∆ 0 and ν B is numerically studied. Here, ∆ 0 is the Born approximated dilepton multiplicity in the absence of external magnetic fields. It is, in particular, shown that for each fixed T and B, in the vicinity of certain threshold energies of virtual photons, ∆ B ≫ ∆ 0 and ∆ ⊥ B ≫ ∆ B . The latter anisotropy may be interpreted as one of the microscopic sources of the macroscopic anisotropies, reflecting themselves, e.g., in the elliptic asymmetry factor v 2 of dileptons. 1 eB = 1 GeV 2 corresponds to B ≃ 1.7 × 10 20 Gauß. 2 See, e.g. [12,13] for a complete analysis of the effect of strong magnetic fields on various phases of quark matters, including chiral and color superconducting phases. See also [14] for the most recent review of the effects induced by magnetic catalysis [15,16] and inverse magnetic catalysis [17] on QCD phase diagram. 3 Studying the effect of hot magnetized plasminos on DPR is rather involved, and will be postponed to our future works.