Local epidermal growth factor delivery using nanopillared chitosan–gelatin films for melanogenesis and wound healing

Altuntaş, Sevde; Dhaliwal, Harkiranpreet Kaur; Radwan, A. E.; Amiji, Mansoor M.; Büyükserin, Fatih

doi:10.1039/d2bm00836j

Cited by 10 publications

(6 citation statements)

References 49 publications

(86 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the past several years, multiple forms of biomaterials used for wound healing have been developed including hydrogels, sponges, and particles. [8][9][10][11] Among which, particles have attracted great attention because of their good therapeutic efficacy and low toxicity. 12,13 Particles with a porous structure show high water absorbability.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of yeast β-glucan/sodium alginate/γ-polyglutamic acid composite particles for hemostasis and wound healing

Zou,

Duan,

Fang

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Fabrication of yeast β-glucan/sodium alginate/γ-polyglutamic acid composite particles for hemostasis and wound healing

Zou,

Duan,

Fang

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…Kim et al 29 employed the conjugation of EGF to hyaluronate, which resulted in delayed degradation and prolonged retention time of EGF, leading to significant improvements in skin tissue regeneration in the wound area. Altuntas et al 30 utilized nanopillar chitosan‐gelatin films for the topical delivery of EGF, which resulted in considerable improvements in wound closure and collagen thickness. These studies highlight the potential of utilizing innovative biomaterials for enhanced EGF delivery and wound healing outcomes.…”

Section: Discussionmentioning

confidence: 99%

The role of epidermal growth factor‐containing topical products on recovery and post‐inflammatory hyperpigmentation prevention after laser surgeries: A systematic review and meta‐analysis

Ying,

Zhang,

Qiu

et al. 2023

J of Cosmetic Dermatology

View full text Add to dashboard Cite

BackgroundPost‐inflammatory hyperpigmentation (PIH) is a common complication after laser surgeries. Recent studies applied epidermal growth factor (EGF) on the lasered area after laser surgery to decrease the incidence of PIH with controversial results. Therefore, a comprehensive literature review of randomized controlled trials (RCTs) was conducted to investigate the issue.MethodsTwo reviewers independently searched the literatures, extracted, and analyzed the data. A total of seven RCTs involving 169 patients were included to evaluate the efficacy of EGF on recovery and PIH prevention after laser surgery.ResultsThe results show that the incidence of PIH in the EGF group was relatively lower than that in the control group, although the difference was not statistically significant (OR 0.64, 95% CI 0.33 ~ 1.25, p = 0.19). However, the EGF groups had a significant decrease in melanin index (MI) scores at the 1st month after the laser surgery when compared to the control groups (SMD −1.57, 95% CI −2.83 ~ −0.31, p = 0.01). In addition, the patients on the EGF side rated significantly higher satisfactory scores (SMD 0.49, 95% CI 0.22 ~ 0.76, p = 0.0004). There was no significant difference as regard to changes in MI at the 2nd week and 2nd month, erythema index (EI), and trans‐epidermal water loss (TEWL) at days 3 and 7 after laser therapy, respectively.ConclusionThe current meta‐analysis found a limited temporary inhibitory effect of EGF‐containing topical products on PIH with no significant effect on reducing post‐laser erythema or promoting epidermal barrier repair. More studies are needed in the future due to the small sample size and marked intergroup heterogeneities.

show abstract

“…Because nanopillars increase surface area, nanopillar surfaces are more valuable than conventional flat surfaces [3]. Due to the promise of nanopillar membranes and films for the creation of protective skin barriers [4], it is important to investigate fabrication technologies that involve the control of the geometry of nanopillars.…”

Section: Extended Abstractmentioning

confidence: 99%

Vibration Analysis of Nanopillared Chitosan Membrane Using HighFrequency Excitation Technique during Solvent Casting Method

Cigane,

Palevicius,

Janusas

2024

Proceedings of the 9th World Congress on Recent Advances in Nanotechnology

View full text Add to dashboard Cite

Local epidermal growth factor delivery using nanopillared chitosan–gelatin films for melanogenesis and wound healing

Abstract: Epidermal growth factor (EGF) is required for various regulations of skin tissue including wound healing, however, it has limited stability due to the physicochemical conditions of the wound milieu. The...

Cited by 10 publications

References 49 publications

Fabrication of yeast β-glucan/sodium alginate/γ-polyglutamic acid composite particles for hemostasis and wound healing

Fabrication of yeast β-glucan/sodium alginate/γ-polyglutamic acid composite particles for hemostasis and wound healing

The role of epidermal growth factor‐containing topical products on recovery and post‐inflammatory hyperpigmentation prevention after laser surgeries: A systematic review and meta‐analysis

Vibration Analysis of Nanopillared Chitosan Membrane Using HighFrequency Excitation Technique during Solvent Casting Method

Contact Info

Product

Resources

About