Motivated by the astrophysical problems of star formations from molecular clouds, we make the first step on the possible mathematical descriptions of molecular clouds. This article first obtain a model describing the physically reasonable molecular clouds by a proposal to remedy the defects of Makino's star model and removing its exterior regularities (i.e., remove its imposed nonphysically exterior free-falling equations). Since some technical and tricky problems occur, this question is not easy and has been asked by Makino's original paper [37] and Rendall's [48] for a long time. We, in this article, establish a reasonable model by Euler-Poisson system for describing the evolution of molecular clouds and obtain the local existence, uniqueness and continuation principle of the classical solution. In the companion article [31], we will develop this description to the long time region, and conclude under certain data (without any symmetry), the developments of the molecular clouds are either global with near-boundary mass accretions (leads to star formations), or blowup at finite time.