Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

Hensch, Takao K.; Fagiolini, Michela; Mataga, Nobuko; Stryker, Michael P.; Baekkeskov, Steinunn; Kash, Shera

doi:10.1126/science.282.5393.1504

Cited by 820 publications

(779 citation statements)

References 84 publications

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“…Inhibition is well known to have a crucial role in the expression and regulation of neural plasticity during development and adulthood: there is evidence, indeed, that the inhibitory tone is essential for the time course of critical period in the visual cortex 16 and it has been demonstrated that strategies decreasing inhibition reactivate developmental levels of plasticity in the adult brain 17 . We quantified the extracellular levels of γ-aminobutyric acid (GABA) and glutamate in the binocular visual cortex of FR and CTL animals using in vivo brain microdialysis and high-performance liquid chromatography (HPLC).…”

Section: Resultsmentioning

confidence: 99%

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Food restriction enhances visual cortex plasticity in adulthood

Spolidoro¹,

Baroncelli²,

Putignano

et al. 2011

Nat Commun

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neural circuits display a heightened sensitivity to external stimuli during well-established windows in early postnatal life. After the end of these critical periods, brain plasticity dramatically wanes. The visual system is one of the paradigmatic models for studying experiencedependent plasticity. Here we show that food restriction can be used as a strategy to restore plasticity in the adult visual cortex of rats. A short period of food restriction in adulthood is able both to reinstate ocular dominance plasticity and promote recovery from amblyopia. These effects are accompanied by a reduction of intracortical inhibition without modulation of brainderived neurotrophic factor expression or extracellular matrix structure. our results suggest that food restriction could be investigated as a potential way of modulating plasticity.

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Section: Resultsmentioning

confidence: 99%

“…Diazepam enhances GABA receptor-mediated current, and is a common tool used for enhancing inhibition in the cerebral cortex 16 . We measured binocularity in monocularly deprived FR rats treated with diazepam by recording C/I VEP ratio in the visual cortex contralateral to the deprived eye.…”

Section: Resultsmentioning

confidence: 99%

Food restriction enhances visual cortex plasticity in adulthood

Spolidoro¹,

Baroncelli²,

Putignano

et al. 2011

Nat Commun

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show abstract

“…BDNF is known to modulate the development and plasticity of the visual cortex (Huang et al, 1999) possibly by regulating the GABAergic inhibitory system, which has a clear role in cortical development (Hensch et al, 1998). We measured BDNF protein and glutamic acid decarboxylase (GAD) 65/67 expression and found that enrichment transiently increases levels of BDNF protein and GAD65/67 expression in the occipital cortex of EC with respect to SC animals before postnatal day (P) 15.…”

Section: Introductionmentioning

confidence: 99%

Acceleration of Visual System Development by Environmental Enrichment

Cancedda¹,

Putignano²,

Sale³

et al. 2004

J. Neurosci.

246

217

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Thus far, the developmental plasticity of the visual system has been studied by altering or reducing visual experience. Here, we investigated whether a complex sensory-motor stimulation, provided by rearing animals in an enriched environment, affects visual system development. We found that raising mice in this condition causes an earlier eye opening, a precocious development of visual acuity, and an accelerated decline of white matter-induced long-term potentiation. These effects are accompanied by a precocious cAMP response element-mediated gene expression and a significant increase of BDNF protein and GAD65/67 expression in enriched pups. In addition, we showed that enriched pups experienced higher levels of licking behavior provided by adult females. Thus, rearing mice from birth in an enriched environment leads to a conspicuous acceleration of visual system development as ascertained at behavioral, electrophysiological, and molecular level.

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“…Genetic reduction of intracortical GABA release blocks the effects of MD that can be restored by local pharmacological enhancement of GABA signaling (3,4). Accelerating the rate of inhibitory cell maturation leads to a precocious period of plasticity (5).…”

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confidence: 99%

Delayed plasticity of inhibitory neurons in developing visual cortex

Gandhi

Yanagawa

Stryker

2008

Proc. Natl. Acad. Sci. U.S.A.

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105

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During postnatal development, altered sensory experience triggers the rapid reorganization of neuronal responses and connections in sensory neocortex. This experience-dependent plasticity is disrupted by reductions of intracortical inhibition. Little is known about how the responses of inhibitory cells themselves change during plasticity. We investigated the time course of inhibitory cell plasticity in mouse primary visual cortex by using functional two-photon microscopy with single-cell resolution and genetic identification of cell type. Initially, local inhibitory and excitatory cells had similar binocular visual response properties, both favoring the contralateral eye. After 2 days of monocular visual deprivation, excitatory cell responses shifted to favor the open eye, whereas inhibitory cells continued to respond more strongly to the deprived eye. By 4 days of deprivation, inhibitory cell responses shifted to match the faster changes in their excitatory counterparts. These findings reveal a dramatic delay in inhibitory cell plasticity. A minimal linear model reveals that the delay in inhibitory cell plasticity potently accelerates Hebbian plasticity in neighboring excitatory neurons. These findings offer a network-level explanation as to how inhibition regulates the experiencedependent plasticity of neocortex.inhibition ͉ ocular dominance ͉ two-photon microscopy ͉ calcium imaging ͉ cortical plasticity

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Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

Cited by 820 publications

References 84 publications

Food restriction enhances visual cortex plasticity in adulthood

Food restriction enhances visual cortex plasticity in adulthood

Acceleration of Visual System Development by Environmental Enrichment

Delayed plasticity of inhibitory neurons in developing visual cortex

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