Local hyperthermia and radiation therapy in the treatment of superficially located lymphomas and recurrent Hodgkin's disease

Donato,; Zurlo, Alfredo; Banelli, E; Santarelli, M; Anselmo, Paola; Martelli, Maurizio; Enrici, R. Maurizi; Biagini, C

doi:10.3892/or.3.6.1043

Cited by 3 publications

(4 citation statements)

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“…In selected patients with skin and lymph node manifestations, radiotherapy is indicated. In lymphoma lesions failing to regress or recurring after irradiation alone, relatively low radiation doses combined with local hyperthermia caused a high CR rate (86)(87)(88). Overall local tumour control was obtained in 37 out of 42 patients, 88% (95% CI 66-97%).…”

Section: Miscellaneous Phase I/ii Studiesmentioning

confidence: 99%

Status of Clinical Hyperthermia

Dahl

Dalene²,

Bc³

et al. 1999

Acta Oncologica

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Section: Miscellaneous Phase I/ii Studiesmentioning

confidence: 99%

Status of Clinical Hyperthermia

Dahl

Dalene²,

Bc³

et al. 1999

Acta Oncologica

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“…As described, this treatment did not avoid systemic evolution of the disease but did successfully resolve the skin lesions and prevent their relapse, thus suggesting that RT combined with HT may have a relevant role in the treatment and relapse prevention of skin lesions [13,14], rather than merely symptom palliation. HT as an adjunct to RT has been a focus of interest in cancer management.…”

Section: Resultsmentioning

confidence: 93%

Plasmacytoid Dendritic Cell Leukemia: A Rapidly Evolving Disease Presenting with Skin Lesions Sensitive to Radiotherapy plus Hyperthermia

et al. 2009

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Plasmacytoid dendritic cell leukemia (pDCL) is a rapidly evolving disease, which frequently presents with skin lesions, particularly nodules and plaques with a typical reddish-brown or brown color. Treatment of pDCL is based on multiagent chemotherapy followed by allogeneic hematopoietic stem cell transplant, but skin lesions may be refractory to therapy. Here, we report on a 61-year-old patient affected by pDCL who first presented with multiple cutaneous nodules and plaques on the trunk. Lesions showed an excellent response to radiotherapy plus hyperthermia. Although this treatment did not avoid the systemic evolution of disease, it resolved skin lesions and prevented their relapse, thus representing a therapeutic option to be used in combination with chemotherapy regimens. The case presentation is followed by a general discussion with an emphasis on the diagnosis and treatment of this rare malignancy. The Oncologist 2009;14:1205-1208 CASE PRESENTATIONA 61-year-old white man was referred with a diagnosis of acute monocytic leukemia cutis manifesting with a 3-month history of skin nodules. The patient presented with reddishbrown or brown multiple skin nodules and plaques up to 5 cm in diameter on the trunk and neck. Brown macules were also present on the upper trunk. Lesions were moderately itchy and painful. He had no systemic symptoms. Physical examination revealed axillary lymphadenopathies. Routine blood tests and a peripheral blood smear were negative. The bone marrow aspirate showed low-level involvement (20%) by medium/large-sized agranular blast cells present-

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“…This mild range of thermal therapy (38–42 °C) has a significant effect on tumor vascular perfusion, tumor immunogenicity, immune function, lymphocyte trafficking, cytokine activity, metabolism, and gene expression, all of which affect the tumor microenvironment. − The localized heating of tumor cells can induce expression of heat shock proteins (HSPs) that act as immunogens to activate the immune system through the maturation of dendritic cells (DC), activation of the cytolytic and migratory capacities of natural killer (NK) cells, stimulation of antigen-dependent T-cell activation, and their IFN-γ secretion and the release of pro- and anti-inflammatory cytokines . Clinically, thermal therapy has been used in combination with radiotherapy, and patients have achieved remission in both Hodgkin’s and NHL . The combination of thermal therapy with other therapies has also been used in clinics during other different cancer treatments. − In this regard, magnetic nanostructures hold an important position as these can be influenced under an RF field to generate heat.…”

mentioning

confidence: 99%

“…14 Clinically, thermal therapy has been used in combination with radiotherapy, and patients have achieved remission in both Hodgkin's and NHL. 15 The combination of thermal therapy with other therapies has also been used in clinics during other different cancer treatments. 16−19 In this regard, magnetic nanostructures hold an important position as these can be influenced under an RF field to generate heat.…”

mentioning

confidence: 99%

Biomimetic Magnetic Nanostructures: A Theranostic Platform Targeting Lipid Metabolism and Immune Response in Lymphoma

et al. 2019

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B-cell lymphoma cells depend upon cholesterol to maintain pro-proliferation and pro-survival signaling via the B-cell receptor. Targeted cholesterol depletion of lymphoma cells is an attractive therapeutic strategy. We report here high-density lipoprotein mimicking magnetic nanostructures (HDL-MNSs) that can bind to the high-affinity HDL receptor, scavenger receptor type B1 (SR-B1), and interfere with cholesterol flux mechanisms in SR-B1 receptor positive lymphoma cells, causing cellular cholesterol depletion. In addition, the MNS core can be utilized for its ability to generate heat under an external radio frequency field. The thermal activation of MNS can lead to both innate and adaptive antitumor immune responses by inducing the expression of heat shock proteins that lead to activation of antigen presenting cells and finally lymphocyte trafficking. In the present study, we demonstrate SR-B1 receptor mediated binding and cellular uptake of HDL-MNS and prevention of phagolysosome formation by transmission electron microscopy, fluorescence microscopy, and ICP-MS analysis. The combinational therapeutics of cholesterol depletion and thermal activation significantly improves therapeutic efficacy in SR-B1 expressing lymphoma cells. HDL-MNS reduces the T 2 relaxation time under magnetic resonance imaging (MRI) more effectively compared with a commercially available contrast agent, and the specificity of HDL-MNS toward the SR-B1 receptor leads to differential contrast between SR-B1 positive and negative cells suggesting its utility in diagnostic imaging. Overall, we have demonstrated that HDL-MNSs have cell specific targeting efficiency, can modulate cholesterol efflux, can induce thermal activation mediated antitumor immune response, and possess high contrast under MRI, making it a promising theranostic platform in lymphoma.

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Local hyperthermia and radiation therapy in the treatment of superficially located lymphomas and recurrent Hodgkin's disease

Cited by 3 publications

References 0 publications

Status of Clinical Hyperthermia

Status of Clinical Hyperthermia

Plasmacytoid Dendritic Cell Leukemia: A Rapidly Evolving Disease Presenting with Skin Lesions Sensitive to Radiotherapy plus Hyperthermia

Biomimetic Magnetic Nanostructures: A Theranostic Platform Targeting Lipid Metabolism and Immune Response in Lymphoma

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