Local hyperthermia in head and neck cancer: mechanism, application and advance

Gao, Siyang; Zheng, Min; Ren, Xiaohua; Tang, Yaling; Liang, Xin‐hua

doi:10.18632/oncotarget.10350

Cited by 59 publications

(49 citation statements)

References 97 publications

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“…Photothermal therapy is based on the resonant photon energy absorbed with light irradiation, resulting in the rapid 7 BioMed Research International generation of heat on the surface of the nanoparticles, which damages and destroys cancer cells. The therapeutic strategy of PTT with nanoparticles provides localized, targeted heating and cytotoxic treatment which can potentially offer more functional and aesthetic results [2,26,27]. ANS have an absorption in the NIR region; however, most biological tissues lack NIR-absorbing chemophores [10,26].…”

Section: Discussionmentioning

confidence: 99%

“…Photothermal therapy (PTT), a type of photo-based therapy, has been developed for the eradication of cancer cells in the primary tumor and the initial stage of cancer metastasis. PTT can also be combined with current therapies to improve their therapeutic outcomes [1][2][3][4]. The therapeutic efficacy of PTT depends on the transformation of light to sufficient heat with photothermal agents such as metal nanostructures, nanocarbons, and organic agents [1].…”

Section: Introductionmentioning

confidence: 99%

“…It is susceptible to hyperthermia death due to its oxygen-independent condition. This hyperthermia induces the necrosis of cancer cells with protein denaturation [2,28,33]. At temperatures greater than 43°C, protein denaturation and disruption of the cellular membrane occur, and some studies have shown ablation of tumor tissues [29,34,35].…”

mentioning

confidence: 99%

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Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Kang

Lee

Park

et al. 2020

BioMed Research International

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The purpose of this study was to investigate the effect of photothermal treatment (PTT) with gold nanoshell (ANS) using a macrophage-mediated delivery system in a head and neck squamous cell carcinoma (HNSCC) cell line. To achieve this, ANSloaded rat macrophages (ANS-MAs) were prepared via the coculture method with ANS. The human HNSCC (FaDu cell) and macrophage (rat macrophage; NR8383 cell) hybrid spheroid models were generated by the centrifugation method to determine the possibility of using ANS-MAs as a cancer therapy. These ANS-MAs were set into the tumor and macrophage hybrid spheroid model to measure PTT efficacy. Kinetic analysis of the spheroid growth pattern revealed that this PTT process caused a decreasing pattern in the volume of the hybrid model containing ANS-MAs (p < 0:001). Comparison with empty macrophages showed harmony between ANS and laser irradiation for the generation of PTT. An annexin V/dead cell marker assay indicated that the PTT-treated hybrid model induced increasing apoptosis and dead cells. Further studies on the toxicity of ANS-MAs are needed to reveal whether it can be considered biocompatible. In summary, the ANS was prepared with a macrophage as the delivery method and protective carrier. The ANS was successfully localized to the macrophages, and their photoabsorption property was stationary. This strategy showed significant growth inhibition of the tumor and macrophage spheroid model under NIR laser irradiation. In vivo toxicology results suggest that ANS-MA is a promising candidate for a biocompatible strategy to overcome the limitations of fabricated nanomaterials. This ANS-MA delivery and PTT strategy may potentially lead to improvements in the quality of life of patients with HNSCC by providing a biocompatible, minimally invasive modality for cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Kang

Lee

Park

et al. 2020

BioMed Research International

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“…The treatment process is accompanied with temperature measurement that can vary from invasive methods using thermometry devices to non-invasive techniques using Magnetic Resonance Imaging ( MRI) or Computed Tomography (CT). The key to the success of the treatment is the control of the injected power and an excellent location and setting of the heating source following the Hyperthermia Treatment Planning (HTP) [32,38].…”

Section: Hyperthermia Optionmentioning

confidence: 99%

Thermal Therapy Modalities for Cancer Treatment: A Review and Future Perspectives

Mellal¹,

Oukaira²,

Kengene³

et al. 2017

Appl Sci Res Rev

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“…For SPT, the reactive oxygen species (ROS) generated by the phototherapeutic agents would clear the heat immunity of the cancer cells . In parallel, the heat produced by the phototherapeutic agents could kill the surviving cancer cells due to the hypoxia of tumor . Thus, SPT could exhibit the synergistic effect of “1 + 1 > 2” in theory.…”

Section: Introductionmentioning

confidence: 99%

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy

Zhao

Xie

Jun-gu

et al. 2019

Adv Healthcare Materials

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of tumor. [7][8][9] Thus, SPT could exhibit the synergistic effect of "1 + 1 > 2" in theory. However, the effect of PDT would be limi ted severely due to the hypoxic microen vironment in the tumor, leading to that the photothermal effect often dominates the therapy efficiency during the syner gistic therapy process. [10][11][12][13][14][15][16] Thus, tradi tional combination of PTT and PDT failed to fully perform the effect of synergistic phototherapy. Consequently, it is very urgent to develop novel SPT agents which can show the truly synergistic and even enhanced effects of PTT and PDT.Recent works indicated that MnO 2 is a versatile nanocarrier for anticancer treat ment. [13][14][15][16][17] MnO 2 nanostructures have been demonstrated to enhance the anti cancer efficiency through the following three approaches: (1) catalyzing H 2 O 2 to generate O 2 to relieve the hypoxic environ ment in the tumor and enhance the PDT effect, [17,18] (2) generating extra heat to improve the PTT efficiency under irradia tion, [10,21] and (3) reacting with glutathione to reduce the consumption of ROS and release the anticancer drug to enhance the synergistic therapy process. [19,20] Therefore, MnO 2 nanocarriers provide a new insight into design strategies for enhancement of SPT effect. Nevertheless, common strategies to utilize MnO 2 nanocarrier for improving the anticancer effects face with the problems of complicated structures and cumbersome preparation process, because the nanosystems usually contain MnO 2 nanocarrier with various morphologies, phototherapy agents, hydrophilic group, and even some functional groups such as protein and RNA. [21][22][23][24] Therefore, developing MnO 2 nanosystems with simple structures for enhancing the synergistic therapeutic effi ciency is urgent but challenging.In order to construct a simple MnO 2 based nanosystem to realize the truly synergistic and even enhanced effects of PTT and PDT, suitable phototherapeutic agents should be selected. Among numerous phototherapeutic agents, nearinfrared (NIR) azaBODIPY dyes, which exhibit both excellent photo thermal and photodynamic effects, were ideal SPT agent for further application in combination with MnO 2 . [25][26][27][28][29] In parallel, to avoid the complex structure and preparation process of the Recent studies indicate that the synergistic phototherapy (SPT) process can simultaneously generate heat for photothermal therapy (PTT) and singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT) to overcome the recurrence of tumors. However, the hypoxic environment in tumors seriously limits the therapeutic effect of the oxygen-dependent PDT, leading to the domination of PTT in the SPT process. Therefore, it is urgent to develop a novel SPT platform for overcoming hypoxia in tumors and improving the therapeutic effect of both PTT and PDT. In this work, a novel phototherapeutic platform based on a nanocomposite of aza-BODIPY/manganese dioxide (MnO 2 ) is developed via simple electrostatic self-assembly. In this design, MnO 2 nanosheets, which coul...

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Local hyperthermia in head and neck cancer: mechanism, application and advance

Cited by 59 publications

References 97 publications

Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Thermal Therapy Modalities for Cancer Treatment: A Review and Future Perspectives

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy

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Local hyperthermia in head and neck cancer: mechanism, application and advance

Cited by 59 publications

References 97 publications

Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Thermal Therapy Modalities for Cancer Treatment: A Review and Future Perspectives

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO2 for Enhancing Tumor Synergistic Therapy

Contact Info

Product

Resources

About

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy