Local immune response in experimental pyelonephritis

Lehmann, James D.; Smith, James W.; Miller, Thomas E.; Barnett, Jack A.; Sanford, Jay P.

doi:10.1172/jci105936

Cited by 88 publications

(46 citation statements)

References 36 publications

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“…The 0 antigen (lipopolysaccharide) has been shown to be a potent immunogen, inducing both systemic and local antibody (1,4). Clinical studies have shown that serum antibody to 0 antigen can be of diagnostic value in patients with pyelonephritis, whereas patients with bladder infection do not develop a serum antibody response (1,5,6).…”

Section: Introductionmentioning

confidence: 99%

The local immune response to Escherichia coli O and K antigen in experimental pyelonephritis.

Smith¹,

Kaijser²

1976

J. Clin. Invest.

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Section: Introductionmentioning

confidence: 99%

The local immune response to Escherichia coli O and K antigen in experimental pyelonephritis.

Smith¹,

Kaijser²

1976

J. Clin. Invest.

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“…The observation that small mononuclear cells within the renal medulla are capable of normal immunoglobulin synthesis would provide data which mitigate against a primary role of urea or creatinine (19). Other investigators have demonstrated that metabolic degradation products, methylguanidine and guanidinosuccinic acid, are retained by poorly functioning kidneys (20)(21)(22)(23) …”

Section: Introductionmentioning

confidence: 99%

Defective cellular immunity in renal failure: depression of reactivity of lymphocytes to phytohemagglutinin by renal failure serum

Newberry¹,

Sanford²

1971

J. Clin. Invest.

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190

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A B S T R A C T In defining host resistance factors inuremia, experiments were designed to assess the effect of renal failure serum upon the reactivity of normal human lymphocytes to phytohemagglutinin in vitro. Normal buffy coat cells were resuspended in sera obtained from normal subjects and from 14 patients with renal failure, then stimulated with phytohemagglutinin M and the cellular response measured by the increase in thymidine or uridine uptake. The mean thymidine uptake by stimulated cells in normal sera was 14,389 ± 1695 (SEM) cpm per 2 X 106 lymphocytes. Uridine uptake under the same conditions was 12,540 ±1887 cpm. Compared to these are a mean thymidine uptake of 2740 ±457 cpm and uridine uptake of 3928 ±667 cpm in renal failure sera. Both differences are significant at P < 0.01 level.For controls representing "chronic illnesses," sera from patients with pneumococcal meningitis, cirrhosis of the liver without jaundice, rheumatoid arthritis, and paraplegia with urinary tract infection did not cause suppression. No single drug had been taken by all the renal failure patients; three patients were taking no drugs.The serum from one patient with acute renal failure suppressed thymidine uptake while her serum obtained after recovery from her illness supported a normal lymphocyte response. Improvement of lymphocyte response was also noted in 9 of 10 sera obtained from patients immediately after hemodialysis. These observations plus the inhibition of stimulated cells by normal serum mixed with renal failure serum indicate the presence of a dialyzable inhibitory factor rather than the absence of a supporting factor in the renal failure sera.Lymphocytes preincubated for 24 hr in renal failure serum responded normally when transferred to normal serum and stimulated. Cells stimulated in normal serum and transferred to renal failure serum within the initial

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“…These finished asymptomatic bacteriuria with E. coli 04 was again antibodies are presumably locally formed. Lehmann et al (23) ' In all patients the histologic examination was consistent with recurrent pyelonephritis. In no patient were deposits of complement component C3 shown.…”

mentioning

confidence: 80%

A Search for Escherichia coli Antigens in Kidneys from Children with Urinary Tract Infection by Means of Immunofluorescence

et al. 1974

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Local immune response in experimental pyelonephritis

Cited by 88 publications

References 36 publications

The local immune response to Escherichia coli O and K antigen in experimental pyelonephritis.

The local immune response to Escherichia coli O and K antigen in experimental pyelonephritis.

Defective cellular immunity in renal failure: depression of reactivity of lymphocytes to phytohemagglutinin by renal failure serum

A Search for Escherichia coli Antigens in Kidneys from Children with Urinary Tract Infection by Means of Immunofluorescence

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