Local immunotherapy: pharmacokinetics and efficacy

Passalacqua, Giovanni; Bagnasco, Marcello; Mariani, Giuliano; Falagiani, P.; Canonica, Giorgio Walter

doi:10.1111/j.1398-9995.1998.tb04084.x

Cited by 18 publications

(8 citation statements)

References 56 publications

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“…In accordance with those studies [9][10][11][12][13]17], in our study significant improvement was observed both in SLIT and SLIT1BCG groups with respect to asthma and rhinitis symptom scores and drug consumption as early as 6 months. One of the parameters we monitored in this study was the number of acute asthma exacerbations, which showed a significant reduction at the end of the study period in both treatment groups.…”

Section: Discussionsupporting

confidence: 92%

“…One of the current hypotheses is induction of tolerance by Langerhans' cells that internalize the antigens in the sublingual mucosa before migrating to the regional lymph nodes, where they act as antigen-presenting cells. This may result in T cell response modifications responsible for oral tolerance [8][9][10]. The tolerogenicity of the oral route has been clearly demonstrated in animal models.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental support for this theory is available. It has been shown that locally administered allergen is taken up by mucosal dendritic cells, and at least in nonsensitized mice, the allergen is then presented to T cells, together with IL-12, thereby biasing the response toward a T helper (Th1) profile and away from the IgE-inducing Th2 profile [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Bacillus Calmette–Guérin‐induced interleukin‐12 did not additionally improve clinical and immunologic parameters in asthmatic children treated with sublingual immunotherapy

Arıkan

Bahceciler

Deniz

et al. 2004

Clin Experimental Allergy

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bacillus Calmette–Guérin‐induced interleukin‐12 did not additionally improve clinical and immunologic parameters in asthmatic children treated with sublingual immunotherapy

Arıkan

Bahceciler

Deniz

et al. 2004

Clin Experimental Allergy

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“…These cells internalize antigens in the sublingual mucosa before migrating to the regional lymph nodes, where they act as antigen-presenting cells. This may result in T-cell response modifications responsible for oral tolerance [30, 31, 32]. Animal experiments point to mucosal vaccination with antigens being potential candidates for mucosal tolerance induction [33].…”

Section: Discussionmentioning

confidence: 99%

Impact of Sublingual Immunotherapy on Specific Antibody Levels in Asthmatic Children Allergic to House Dust Mites

Bahceciler

Arıkan²,

Taylor³

et al. 2005

Int Arch Allergy Immunol

125

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Objective: To evaluate the clinical outcome and changes in allergen-specific antibodies during sublingual immunotherapy (SLIT) in house dust mite (HDM)-allergic asthma patients and to compare levels of allergen-specific antibodies in HDM-allergic patients before and after treatment with that of healthy controls. Method: Thirty-one asthma patients allergic to HDM were studied. Patients in groups I (n = 17) and II (n = 14) received SLIT with a standardized Dermatophagoides pteronyssinus plus Dermatophagoides farinae 50/50 extract for 6 and 12 months, respectively. A group of healthy children (n = 8) were enrolled as controls. Patients in both groups were evaluated at the start and at the end of treatment according to daily symptom and medication scores, lung function and skin prick tests, PC₂₀, blood eosinophil count, and Der-p-1-specific IgE, IgA, IgG1 and IgG4 levels. Results: Drug consumption decreased significantly in both groups. Furthermore, PC₂₀ and forced expiratory flow between 25 and 75% of vital capacity of patients in group II improved significantly. Although specific IgA, IgG1 and IgG4 levels did not change throughout the treatment period, total eosinophil count and specific IgE decreased significantly in both groups. According to baseline measurements, specific IgA levels of patients in groups I and II were significantly lower than that of controls. This difference disappeared at the end of the treatment period in both groups. Conclusion: SLIT seems to be effective in ameliorating clinical symptoms, drug consumption and bronchial hyperreactivity, and results in downregulation of Der-p-1-specific IgE production. Furthermore, at the end of SLIT, specific IgA levels, which were decreased compared to healthy controls initially, did no longer differ between patients and controls.

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“…These cells are, most likely, critically involved in the binding and persistence of allergens in the sublingual area [47,48]. Oral mucosal Langerhans-like dendritic cells differ from the epidermal Langerhans cells in that they constitutively have higher expression of High affinity IgE receptor, Major histocompatibility complex (MHC) I and MHC II, as well as costimulatory molecules CD40, CD80/B7.1 and CD86/B7.2.…”

Section: Immunological Mechanismsmentioning

confidence: 99%

Comparing subcutaneous and sublingual ımmunotherapy

Bahceciler¹,

Galip²

2012

Current Opinion in Allergy &Amp; Clinical Immunology

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SLIT and SCIT are both clinically effective in the treatment of respiratory allergic diseases with slight differences in the early phase in terms of onset of clinical efficacy and simultaneous immunological responses. Both SLIT and SCIT induce similar T-cell responses in time, but specific IgG4-blocking antibody responses are more prevalent following SCIT. Further head-to-head studies addressing the preventive effect of monotherapy and the efficacy and immunological responses of nonrelated multiallergen immunotherapy in polysensitized patients are warranted.

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Local immunotherapy: pharmacokinetics and efficacy

Cited by 18 publications

References 56 publications

Bacillus Calmette–Guérin‐induced interleukin‐12 did not additionally improve clinical and immunologic parameters in asthmatic children treated with sublingual immunotherapy

Bacillus Calmette–Guérin‐induced interleukin‐12 did not additionally improve clinical and immunologic parameters in asthmatic children treated with sublingual immunotherapy

Impact of Sublingual Immunotherapy on Specific Antibody Levels in Asthmatic Children Allergic to House Dust Mites

Comparing subcutaneous and sublingual ımmunotherapy

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