Local Increase of Sleep Slow Wave Activity after Three Weeks of Working Memory Training in Children and Adolescents

Pugin, Fiona; Metz, Andreas; Wolf, Martin; Achermann, Peter; Jenni, Oskar G.; Huber, Reto

doi:10.5665/sleep.4580

Cited by 57 publications

(57 citation statements)

References 34 publications

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“…Various forms of conditioning can result in modified sleep states in the post-conditioning period in both humans and rodents (Sanford et al, 2003b, Eschenko et al, 2006, Stickgold and Walker, 2007, Molle et al, 2009, Diekelmann and Born, 2010, Barnes et al, 2011). The post-conditioning changes in sleep, or sleep oscillations can be local to the involved circuits (Huber et al, 2004, Pugin et al, 2015) Replay of recently acquired information can occur during post-conditioning sleep, strengthening those memories (Skaggs and McNaughton, 1996, Stickgold and Walker, 2007, Popa et al, 2010, Abel et al, 2013, Barnes and Wilson, 2014). In addition, post-conditioning reset of synaptic strength can occur during sleep, as a homeostatic mechanism for maintaining synapses and circuits within their most dynamic range (Huber et al, 2004, Liu et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Developmental ethanol exposure-induced sleep fragmentation predicts adult cognitive impairment

et al. 2016

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Developmental ethanol exposure can lead to long-lasting cognitive impairment, hyperactivity, and emotional dysregulation among other problems. In healthy adults, sleep plays an important role in each of these behavioral manifestations. Here we explored circadian rhythms (activity, temperature) and slow-wave sleep in adult mice that had received a single day of ethanol exposure on postnatal day 7 and saline littermate controls. We tested for correlations between slow-wave activity and both contextual fear conditioning and hyperactivity. Developmental ethanol resulted in adult hyperactivity within the home cage compared to controls but did not significantly modify circadian cycles in activity or temperature. It also resulted in reduced and fragmented slow-wave sleep, including reduced slow-wave bout duration and increased slow-wave/fast-wave transitions over 24 hour periods. In the same animals, developmental ethanol exposure also resulted in impaired contextual fear conditioning memory. The impairment in memory was significantly correlated with slow-wave sleep fragmentation. Furthermore, ethanol treated animals did not display a post-training modification in slow-wave sleep which occurred in controls. In contrast to the memory impairment, sleep fragmentation was not correlated with the developmental ethanol-induced hyperactivity. Together these results suggest that disruption of slow-wave sleep and its plasticity are a secondary contributor to a subset of developmental ethanol exposure's long-lasting consequences.

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Section: Discussionmentioning

confidence: 99%

Developmental ethanol exposure-induced sleep fragmentation predicts adult cognitive impairment

et al. 2016

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“…There are already a number of clues from studies in humans, rodents and flies that sleep need increases following tasks or experiences that specifically engage selective attention. In humans, training in visual learning, perception and working memory tasks leads to increases in slow-wave activity, a marker of sleep pressure, in brain regions that are important for visual processing and attention [50, 81-83]. Slow wave activity also increases in rats following operant learning or when they explore a novel environment [84, 85].…”

Section: Sleep and Attention Regulate Each Othermentioning

confidence: 99%

The Yin and Yang of Sleep and Attention

Kirszenblat

Swinderen

2015

Trends in Neurosciences

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Sleep is not a single state, but a complex set of brain processes that supports a number of physiological needs. Sleep deprivation is known to affect attention in many animals, suggesting that a key function of sleep is to regulate attention. Conversely, tasks that require more attention drive sleep need and sleep intensity. Attention involves the ability to filter incoming stimuli based on their relative salience, and this is likely to require coordinated synaptic activity across the brain. This capacity may have only become possible with the evolution of related neural mechanisms that support two key sleep functions: stimulus suppression and synaptic plasticity. We argue here that sleep and attention may have co-evolved as brain states that regulate each other.

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“…Moreover, subjects with a stronger increase in spindle density showed more overnight improvement in speed and accuracy. A study on the effect of an intensive working memory training on subsequent sleep in children and adolescents aged 10–16 years showed increased SWA, which was positively associated with overnight increments in working memory performance (Pugin et al., ).…”

Section: Introductionmentioning

confidence: 99%

Sleep spindle characteristics and sleep architecture are associated with learning of executive functions in school‐age children

Vermeulen

Heijden

Swaab

et al. 2018

Journal of Sleep Research

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The macro‐ and microstructural characteristics of sleep electroencephalography have been associated with several aspects of executive functioning. However, only a few studies have addressed the association of sleep characteristics with the learning involved in the acquisition of executive functions, and no study has investigated this for planning and problem‐solving skills in the developing brain of children. The present study examined whether children's sleep stages and microstructural sleep characteristics are associated with performance improvement over repeated assessments of the Tower of Hanoi task, which requires integrated planning and problem‐solving skills. Thirty children (11 boys, mean age 10.7 years, SD = 0.8) performed computerized parallel versions of the Tower of Hanoi three times across 2 days, including a night with polysomnographically assessed sleep. Pearson correlations were used to evaluate the associations of Tower of Hanoi solution time improvements across repeated assessments with sleep stages (% of total sleep time), slow‐wave activity, and fast and slow spindle features. The results indicated a stronger performance improvement across wake in children with more Stage N2 sleep and less slow‐wave sleep. Stronger improvements across sleep were present in children in whom slow spindles were more dense, and in children in whom fast spindles were less dense, of shorter duration and had less power. The findings indicate that specific sleep electroencephalography signatures reflect the ability of the developing brain to acquire and improve on integrated planning and problem‐solving skills.

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Local Increase of Sleep Slow Wave Activity after Three Weeks of Working Memory Training in Children and Adolescents

Cited by 57 publications

References 34 publications

Developmental ethanol exposure-induced sleep fragmentation predicts adult cognitive impairment

Developmental ethanol exposure-induced sleep fragmentation predicts adult cognitive impairment

The Yin and Yang of Sleep and Attention

Sleep spindle characteristics and sleep architecture are associated with learning of executive functions in school‐age children

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