Local injury to the endometrium: its effect on implantation

Li, Rong; Hao, Guiqin

doi:10.1097/gco.0b013e32832a0654

Cited by 105 publications

(81 citation statements)

References 19 publications

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“…The production of the injury-induced cytokines IP10, MCP1, and CCL4 was shown to be regulated by estrogen (Boucher et al 2000, Kitaya et al 2003, Sentman et al 2004, Carlino et al 2008. Local injury of the endometrium during the proliferative phase of the menstrual cycle substantially increases endometrial expression of estrogen receptors in the following secretory phase (Li & Hao 2009). Therefore, this reciprocal regulation of estrogen and pro-inflammatory cytokines may indicate that the estrogen-induced proliferation in the endometrium is mediated by cytokines.…”

Section: Discussionmentioning

confidence: 99%

Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action

Gnainsky¹,

Granot²,

Aldo³

et al. 2015

Reproduction

139

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A decade ago, we first reported that endometrial biopsy significantly improves the success of pregnancy in IVF patients with recurrent implantation failure, an observation that was later confirmed by others. Recently, we have demonstrated that this treatment elevated the levels of endometrial pro-inflammatory cytokines and increased the abundance of macrophages (Mac) and dendritic cells (DCs). We therefore hypothesised that the biopsy-related successful pregnancy is secondary to an inflammatory response, and aimed at deciphering its mechanism of action. Supporting our hypothesis, we found that the pro-inflammatory TNFa stimulated primary endometrial stromal cells to express cytokines that attracted monocytes and induced their differentiation into DCs. These monocytederived DCs stimulated endometrial epithelial cells to express the adhesive molecule SPP1 (osteopontin (OPN)) and its receptors ITGB3 and CD44, whereas MUC16, which interferes with adhesion, was downregulated. Other implantation-associated genes, such as CHST2, CCL4 (MIP1B) and GROA, were upregulated by monocyte-derived Mac. These findings suggest that uterine receptivity is mediated by the expression of molecules associated with inflammation. Such an inflammatory milieu is not generated in some IVF patients with recurrent implantation failure in the absence of local injury provoked by the biopsy treatment.Reproduction (2015) 149 75-85

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Section: Discussionmentioning

confidence: 99%

Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action

Gnainsky¹,

Granot²,

Aldo³

et al. 2015

Reproduction

139

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“…That is to say, the rate of successful implantation in patients with endometrial trauma was 10.9% while the rate of success in the control group was 3.38% (4). In another research performed by Li et al in the Infertility Department of Shenzhen University of China it was found out that local endometrial trauma leads to an increase in the success of implantation in IVF patients (7). In a study by Zhou et al in the Infertility Department of Shenzhen University of China, a number of IVF patients were examined.…”

Section: Discussionmentioning

confidence: 94%

The Effect of Local Endometrial Injury and GnRH Agonist on Pregnancy Rate in Patients With Recurrent Implantation Failure

Farzadi¹,

Arefeh²,

Ghasemzadeh³

et al. 2015

IJWHR

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IntroductionInfertility is defined as the failure of pregnancy following one year of unprotected sexual intercourse without using contraception. Approximately 85%-90% of healthy couples will be pregnant within 6 months in a year, and often infertility affects about 10%-15% of couples (1). Contrary to public perception, the fertility rate has remained relatively unchanged over the past 3 decades, however, the evaluation and treatment of infertility has changed dramatically over the same period. Several important advances in this field have the greatest impact; the most important of which are in vitro fertilization (IVF) and assisted reproductive technology (ART) (1). Approximately one third of women who have attempted for IVF have become pregnant. Thus, failure in this process implies on a defect in implantation of embryo or shortly after it (1). Although delivery rate has improved enormously following embryo transfer during IVF, it is clear that the majority of IVF-ET cycles are still not successful, and in most cases, an obvious explanation does not exist except for the failure of the replacement process (1). Controlled ovarian hyper (COH) stimulation is an important factor in the success of IVF-ET. However, despite great advances in ovarian stimulation protocols and fertilization, implantation per embryos is roughly 15%, thus a lot of couples have left fertility treatment after failure in pregnancy (2). In couples with recurrent implantation failure (RIF) (i.e. after 3 cycles of good embryo transfer are not pregnant) a series of multiple therapeutic strategies have been proposed, including hysteroscopy, endometrial trauma and changes in stimulation protocols, blastocyst assisted hatching transfer and pre-implantation genetic diagnosis (PGD) for aneuploidy. The advantage of the strategies over each other, however, is not clear. Local trauma to the endometrium in candidate patients for IVF may lead to acidolization and increased potential of implantation failure (2). Prognostic factors in IVF success depends on factors including maternal age, ovarian reserve status and pre-ability of the reproductive system. Younger women with normal ovarian reserve have more probability of pregnancy in comparison with older woman with diminished ovarian reserve. Also, women who have previously failed IVF Abstract Objectives: These days, infertility is one of the most common diseases in the community involving 10%-15% of the couples. One method of infertility treatment is assisted reproductive technology (ART). Recently studies have shown that local endometrial injury in patients treated with in vitro fertilization (IVF) cause treatment failure and subsequently decrease the implantation rates. The aim of this study was to show the direct relationship between local endometrial injury and increasing recurrent implantation failure (RIF). Materials and Methods: Our study populations included patients that experienced at least two or more RIFs during IVF which was performed in the Department of Obstetrics and Gynecology of Tabriz Uni...

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“…This improvement in implantation after endometrial injury can be explained by 3 suggestions. First postulation is the increased decidualization in response to local injury [4]. Second hypothesis, the considerable increase in the release of cytokines, interleukins, growth factors, macrophages, and dendritic cells with endometrial healing, all of which are of benefit in the process of implantation [4] [5].…”

Section: Et Al In 2003 Was the Very Firstmentioning

confidence: 99%

“…First postulation is the increased decidualization in response to local injury [4]. Second hypothesis, the considerable increase in the release of cytokines, interleukins, growth factors, macrophages, and dendritic cells with endometrial healing, all of which are of benefit in the process of implantation [4] [5]. Third is the accelerated maturation of the endometrium in response to controlled ovarian stimulation during ART [6].…”

Section: Et Al In 2003 Was the Very Firstmentioning

confidence: 99%

Endometrial Ice Application Prior to Embryo Transfer in Cases of Recurrent Unexplained <i>In-Vitro</i> Fertilization Failure: A Pilot Study

El-Halwagy¹,

Al-Gergawy²

2017

OJOG

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Introduction: This prospective pilot study was done to get preliminary data about a new technique of inflecting endometrial injury in order to improve implantation rate in IVF cases. Patients and methods: 60 patients were enrolled and randomly distributed into 3 groups. Each group included 20 patients. This study was conducted in the Egyptian consultants for infertility management and IVF center Tanta-Egypt, in the period from January 2015 to March 2016. In group A (study group 1), the 20 patients included in this group underwent endometrial scratching once at day 21 of menstrual cycle in the cycle prior to ET by a 4 mm disposable Karman's cannula inserted through the cervical os. While in group B (study group 2), the 20 patients underwent the new technique of endometrial Ice bars application for 10 minutes at day 7 of the embryo transfer cycle to inflect the physical trauma required for the change in the endometrial receptivity. In Group C (control group), the 20 patients didn't receive any extra action rather than the ordinary preparation for embryo transfer. The primary outcome measures of the study were the clinical pregnancy rate and the number of pregnancies that exceeded 14 weeks of gestation. The secondary outcome measures were multiple pregnancy and miscarriage ratios. Results: The results of this pilot study shows a (>14 weeks) pregnancy rate which is equal in the endometrial icing (30% n = 6/20) and endometrial scratching group (30% n = 6\20). The >14 weeks pregnancy rate in both groups is higher than the control group (25% n = 5/20). The small number of patients in the pilot study may explain the difference to be statistically non-significant. The abortion rate was 33.3% (n = 3/9) in the scratching group and 25% (n = 2/8) in the icing group and 16.6% (n = 1/5) in the control group. The multiple pregnancy rate was 16.6% (n = 1/6) in the scratching group and 33.3% (n = 2/6) in the icing group and 20% (n = 1/5) in the control group. Conclusion: Endometrial icing is a new technique of endometrial injury which deserves more studies to test its efficacy in improving embryo im-

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Local injury to the endometrium: its effect on implantation

Abstract: Local injury to endometria of IVF patients in controlled ovarian hyperstimulation cycle may increase the incidence of embryo implantation.

Cited by 105 publications

References 19 publications

Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action

Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action

The Effect of Local Endometrial Injury and GnRH Agonist on Pregnancy Rate in Patients With Recurrent Implantation Failure

Endometrial Ice Application Prior to Embryo Transfer in Cases of Recurrent Unexplained <i>In-Vitro</i> Fertilization Failure: A Pilot Study

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Local injury to the endometrium: its effect on implantation

Abstract: Local injury to endometria of IVF patients in controlled ovarian hyperstimulation cycle may increase the incidence of embryo implantation.

Cited by 105 publications

References 19 publications

Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action

Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action

The Effect of Local Endometrial Injury and GnRH Agonist on Pregnancy Rate in Patients With Recurrent Implantation Failure

Endometrial Ice Application Prior to Embryo Transfer in Cases of Recurrent Unexplained &lt;i&gt;In-Vitro&lt;/i&gt; Fertilization Failure: A Pilot Study

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Endometrial Ice Application Prior to Embryo Transfer in Cases of Recurrent Unexplained <i>In-Vitro</i> Fertilization Failure: A Pilot Study