Local Intracerebral Administration of Paclitaxel with the Paclimer® Delivery System: Toxicity Study in a Canine Model

Pradilla, Gustavo; Wang, Paul P.; Gabikian, Patrik; Li, Khan; Magee, Carolyn; Walter, Kevin A.; Brem, Henry

doi:10.1007/s11060-005-5531-z

Cited by 49 publications

(24 citation statements)

References 32 publications

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“…A biodegradable polymer PTX microsphere, Paclimer, was developed and examined in various cancer xenografts and patients with ovarian cancer (24,25). Paclimer contains 10% PTX (w/w) with microspheres ranging in size between 20 to 200 Am in diameter (median diameter of 53 Am).…”

Section: Discussionmentioning

confidence: 99%

Translymphatic Chemotherapy by Intrapleural Placement of Gelatin Sponge Containing Biodegradable Paclitaxel Colloids Controls Lymphatic Metastasis in Lung Cancer

Liu¹,

Meisner²,

Kwong³

et al. 2009

Cancer Research

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As a means of treating lymphatic metastasis from lung cancer, the pharmacokinetics and therapeutic effects of an intrapleural (ipl) implantable drug delivery system consisting of a gelatin sponge impregnated with polylactide-co-glycolide paclitaxel (PLGA-PTX) microspheres were studied. PLGA-PTX with 7% (w/w) drug loading were incorporated into gelatin matrix. The pharmacokinetics were studied in rats with one of the following regimens: (a) Taxol 8 mg/kg by i.v. injection; (b) Taxol 8 mg/kg ipl; (c) PLGA-PTX (100 mg/kg) ipl; (d) sponge containing PLGA-PTX (100 mg/kg) ipl. PTX concentrations in lymph node and plasma were determined by liquid chromatography mass spectrometry, and the area under the curve (AUC) was calculated. Therapeutic efficacy was assessed in an orthotopic lung cancer model with tumor resection 14 days following tumor implantation. Animals were randomized to ipl placement of PLGA-PTX sponge, placebo sponge, or no treatment. Lymph node metastases were examined at 32 d. The results show that the mediastinal lymph node AUC was significantly higher with ipl.

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Section: Discussionmentioning

confidence: 99%

Translymphatic Chemotherapy by Intrapleural Placement of Gelatin Sponge Containing Biodegradable Paclitaxel Colloids Controls Lymphatic Metastasis in Lung Cancer

Liu¹,

Meisner²,

Kwong³

et al. 2009

Cancer Research

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“…In order to achieve a prolonged period of function, maximized efficiency, and minimized unwanted side effects to healthy tissues, methods such as local and sustained postsurgical drug delivery have been explored. 101 Electrospun fabrics loaded with anticancer drugs can be conveniently inserted to cover the solid tumor site, and this not only provides high local dosage with incorporation of small amounts of the drug but also reduces the need for frequent administrations, resulting in patient convenience.…”

Section: Cancer Therapymentioning

confidence: 99%

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

204

104

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Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.

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“…The limited ability of most chemotherapeutic agents to penetrate the blood-brain barrier (BBB) (1)(2)(3)(4) has been addressed by the development of polymeric devices for local delivery of chemotherapeutic agents (5)(6)(7); these devices bypass the BBB while reducing the risk of systemic toxicity effects.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel Matrix Entrapping PLGA-Paclitaxel Microspheres: Drug Delivery with Near Zero-Order Release and Implantability Advantages for Malignant Brain Tumour Chemotherapy

et al. 2009

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Local Intracerebral Administration of Paclitaxel with the Paclimer® Delivery System: Toxicity Study in a Canine Model

Cited by 49 publications

References 32 publications

Translymphatic Chemotherapy by Intrapleural Placement of Gelatin Sponge Containing Biodegradable Paclitaxel Colloids Controls Lymphatic Metastasis in Lung Cancer

Translymphatic Chemotherapy by Intrapleural Placement of Gelatin Sponge Containing Biodegradable Paclitaxel Colloids Controls Lymphatic Metastasis in Lung Cancer

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Hydrogel Matrix Entrapping PLGA-Paclitaxel Microspheres: Drug Delivery with Near Zero-Order Release and Implantability Advantages for Malignant Brain Tumour Chemotherapy

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