Local intramuscular administration of ANG1 and VEGF genes using plasmid vectors mobilizes CD34+ cells to peripheral tissues and promotes angiogenesis in an animal model

Skóra, Jan; Antkiewicz, Maciej; Kupczyńska, Diana; Kulikowska, Katarzyna; Strzelec, Bartłomiej; Janczak, Dariusz; Barć, Piotr

doi:10.1016/j.biopha.2021.112186

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…18 Increasing VEGF expression in tissues seems to require the recruitment of CD34 + bone marrow stem cells into injured tissues from circulation. 19–22 In this study, we confirmed increased VEGF expression 3 h after HIIE concurrent with CD34 + cell infiltration in human skeletal muscle. Taken together, the results of the study suggest the role of CD34 + bone marrow stem cells in exercise-induced muscle regeneration in humans.…”

Section: Discussionsupporting

confidence: 76%

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Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise

Dewi,

Liao,

Jean

et al. 2024

Food Funct.

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Section: Discussionsupporting

confidence: 76%

“…18 Increasing VEGF expression in tissues seems to require the recruitment of CD34 + bone marrow stem cells into injured tissues from circulation. [19][20][21][22] In this study, we confirmed increased VEGF expression 3 h after HIIE concurrent with CD34 + cell infiltration in human skeletal muscle. Taken…”

Section: Discussionsupporting

confidence: 76%

Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise

Dewi,

Liao,

Jean

et al. 2024

Food Funct.

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show abstract

“…Second, we had no data about hematopoietic stem cells. Hematopoietic stem cells, such as CD34-positive cells, might play an important role in the present results, as CD34-positive cells contribute to the development of structural atherosclerosis [ 26 ] and progression of angiogenesis [ 27 ]. Further investigation with data on CD34-positive cells is necessary.…”

Section: Discussionmentioning

confidence: 99%

VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study

et al. 2022

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Previous studies have reported a close correlation between vascular endothelial growth factor (VEGF), which plays an important role in angiogenesis, and human T-cell leukemia virus 1 (HTLV-1). However, an association between genetic characteristics related to VEGF and HTLV-1 infection has not yet been reported. Because the VEGF polymorphism rs3025039 is inversely associated with serum concentrations of VEGF, we focus on rs3025039 in the present study. To clarify the association between the VEGF polymorphism rs3025039 and HTLV-1 infection, a cross-sectional study of 1924 Japanese individuals aged 60–79 years who participated in general health check-ups was conducted. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (CIs) for HTLV-1 infection in relation to rs3025039 genotype were calculated with adjustment for known confounders. Compared with rs3025039 CC-homozygotes, (T) allele carriers had a significantly lower OR for HTLV-1 infection. The adjusted OR and 95% CI for HTLV-1 infection was 0.70 (0.54–0.91) (p = 0.009). Genetic characteristics related to lower angiogenesis activity might be associated with a lower chance of establishing HTLV-1 infection. Although further investigation is necessary, angiogenesis might play a crucial role in the establishment of HTLV-1 infection.

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Comprehensive analysis of the cardiac whole-transcriptome expression profiling involved in rehabilitation exercise improving myocardial remodeling after acute myocardial infarction

Chen,

et al. 2024

Preprint

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Rehabilitation exercise (RE) has been shown to mitigate cardiac remodeling and enhance cardiac function in patients with acute myocardial infarction (AMI). However, the precise molecular mechanisms underlying these effects remain incompletely elucidated. In this study, we established a mice model of acute myocardial infarction (AMI) and implemented an 8-week rehabilitation exercise intervention. Whole-transcription sequencing was conducted to examine the expression patterns of mRNA and non-coding RNAs (ncRNAs) in the myocardium of mice with AMI, with and without rehabilitation exercise (RE). GO, KEGG pathway enrichment and protein-protein interaction (PPI) network analyses were performed. And the mRANs within the ceRNA network were validated by RT-PCR. Our findings demonstrate that RE effectively enhances cardiac function, attenuates fibrosis and promotes angiogenesis in the myocardial tissue following MI. Furthermore, bio informatics tools and databases were utilized to investigate potential functions and associations of non-coding RNAs. Our data revealed that: a total of 100 long ncRNAs (lncRNAs), 14 microRNAs (miRNAs), 131 circular RNAs (circRNAs), and 1028 messenger RNAs (mRNAs) were significant. The most prominent pathways involved in RE-mediated improvement of cardiac remodeling after AMI are the PI3K-Akt signaling pathway, cytokine − cytokine receptor interaction, chemokine signaling pathway and MAPK signaling pathway. In addition, lncRNA‒miRNA-mRNA and circRNA-miRNA‒mRNA networks of RE-mediated improvement of cardiac remodeling after AMI were constructed. The present study elucidates the physiological roles of mRNA and ncRNAs in facilitating cardiac remodeling post-AMI. Our findings establish a theoretical framework for investigating the mechanisms underlying cardiac remodeling after AMI, while also providing valuable insights for exploring potential therapeutic interventions for AMI.

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Local intramuscular administration of ANG1 and VEGF genes using plasmid vectors mobilizes CD34+ cells to peripheral tissues and promotes angiogenesis in an animal model

Cited by 6 publications

References 32 publications

Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise

Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise

VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study

Comprehensive analysis of the cardiac whole-transcriptome expression profiling involved in rehabilitation exercise improving myocardial remodeling after acute myocardial infarction

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