Information on temporal and spatial variation in weed seedling populations within agricultural fields is very important for weed population assessment and management. Primarily, spatial information allows a potential reduction in herbicide use, when post-emergent herbicides are only applied to field sections with high weed infestation levels. This paper presents a system for sitespecific weed control in sugar beet, maize, winter wheat, winter barley, winter rape and spring barley. The system includes on-line weed detection using digital image analysis, computer-based decision making and GlobalPositioning System-controlled patch spraying. In a 2year study, herbicide use with this map-based approach was reduced in winter cereals by 6-81% for herbicides against broad leaved weeds and 20-79% for grass weed herbicides. Highest savings were achieved in cereals followed by sugar beet, maize and winter rape. The efficacy of weed control varied from 85% to 98%, indicating that site-specific weed management will not result in higher infestation levels in the following crops. Keywords: weed distribution, site-specific weed control, patch spraying, on-line weed detection, decision support systems, crop rotation. GERHARDS R & OEBEL H (2006) Practical experiences with a system for site-specific weed control in arable crops using real-time image analysis and GPS-controlled patch spraying. Weed Research 46, 185-193.