Local Oral Delivery Agents with Anti-Biofilm Properties for the Treatment of Periodontitis and Peri-Implantitis. A Narrative Review

Elnagdy, Shorouk; Raptopoulos, Michail; Kormas, Ioannis; Pedercini, Alessandro; Wolff, Larry F.

doi:10.3390/molecules26185661

Cited by 10 publications

(3 citation statements)

References 109 publications

(126 reference statements)

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“…Among them, quercetin (QUE), a flavonoid compound ubiquitously present in roots and leaves of various vegetables, has a plethora of beneficial effects on human health, including in preventing and treating various systemic and oral diseases [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Cristo¹,

Valentino²,

Luca³

et al. 2022

Molecules

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The management of periodontitis remains a vital clinical challenge due to the interplay between the microorganisms of the dental biofilm and the host inflammatory response leading to a degenerative process in the surrounding tissues. Quercetin (QUE), a natural flavonol found in many foods, including apples, onions and tea, has exhibited prolonged and strong antibiofilm and anti-inflammatory effects both in vitro and in vivo. However, its clinical application is limited by its poor stability and water solubility, as well as its low bioavailability. Thus, in the present study, electrospun polylactic acid (PLA) nanofibers loaded with different amounts (5–10% w/w) of QUE were produced to rapidly respond to the acidic microenvironment typical of periodontal pockets during periodontal disease. This strategy demonstrated that PLA-QUE membranes can act as a drug reservoir releasing high QUE concentrations in the presence of oral bacterial infection (pH < 5.5), and thus limiting Pseudomonas aeruginosa PAO1 and Streptococcus mutans biofilm maturation. In addition, released QUE exerts antioxidant and anti-inflammatory effects on P. gingivalis Lipopolysaccharide (LPS)-stimulated human gingival fibroblast (HGFs). The reported results confirmed that PLA-QUE membranes could inhibit subgingival biofilm maturation while reducing interleukin release, thereby limiting host inflammatory response. Overall, this study provided an effective pH-sensitive drug delivery system as a promising strategy for treating periodontitis.

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Section: Introductionmentioning

confidence: 99%

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Cristo¹,

Valentino²,

Luca³

et al. 2022

Molecules

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show abstract

“…Th), infiltration of inflammatory cells, and optical density of IL-1, TNF-α, and TGF-β. Another study developed a chitosan/cyclodextrin drug delivery system loaded with minocycline, which can inhibit the biofilm formation of Streptococcus gordonii and P. gingivalis (Elnagdy et al, 2021;Li et al, 2021). The developed drug delivery system alleviated several histological changes, including GI, TM, the distance between CEG and ABC, proliferation and erosion of periodontal epithelial cells, and bone resorption.…”

Section: Trend Analysis Of Marine Bioactive Substances (Mbs) Against ...mentioning

confidence: 99%

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Lee¹,

Kwon²,

Jung³

2023

Fish Aquat Sci

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Marine bioactive substances (MBS), such as phlorotannins, collagens, peptides, sterols, and polysaccharides, are increasing attention as therapeutic agents for several diseases due to their pharmacological effects. Previous studies have demonstrated the biological activities of MBS including antibacterial, anticoagulant, antidiabetic, antimicrobial, anti-inflammatory activities. Among numerous human diseases, periodontitis is one of the high-prevalence inflammatory diseases in the world. To treat periodontitis, several surgeries (bone grafting, flap surgery, and soft tissue graft) are usually used. However, the surgery for patients with chronic periodontitis induces several side effects, including additional inflammatory responses at the operated site, chronic wound healing, and secondary surgery. Therefore, this review assessed the most recent trends in MBS using Google Scholar, PubMed, and Web of Science search engines to develop marine-derived therapeutic agents for periodontitis. Further, we summarized the current applications and therapeutic potential of MBS to serve as a reference for developing novel technologies applied to MBS against periodontitis treatment.

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“…The previous studies have demonstrated that the resistance of bacteria to antibiotics after forming biofilms is 1000 times higher than that in the floating state, which also increases the persistence and recurrence of bacterial infection [ 1 , 2 ]. Biofilms can cause many diseases, such as periodontitis [ 3 ], otitis media [ 4 , 5 ], osteomyelitis [ 6 , 7 ]. Furthermore, it should be noted that biofilms have the capability to adhere to various materials, including catheters [ 8 , 9 , 10 ], prosthetic joints [ 7 , 11 ], contact lenses [ 12 ], mechanical artificial heart valves [ 13 ], and others.…”

Section: Introductionmentioning

confidence: 99%

LC-AMP-F1 Derived from the Venom of the Wolf Spider Lycosa coelestis, Exhibits Antimicrobial and Antibiofilm Activities

Song,

Wang,

Liu

et al. 2024

Pharmaceutics

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In recent years, there has been a growing interest in antimicrobial peptides as innovative antimicrobial agents for combating drug-resistant bacterial infections, particularly in the fields of biofilm control and eradication. In the present study, a novel cationic antimicrobial peptide, named LC-AMP-F1, was derived from the cDNA library of the Lycosa coelestis venom gland. The sequence, physicochemical properties and secondary structure of LC-AMP-F1 were predicted and studied. LC-AMP-F1 was tested for stability, cytotoxicity, drug resistance, antibacterial activity, and antibiofilm activity in vitro compared with melittin, a well-studied antimicrobial peptide. The findings indicated that LC-AMP-F1 exhibited inhibitory effects on the growth of various bacteria, including five strains of multidrug-resistant bacteria commonly found in clinical settings. Additionally, LC-AMP-F1 demonstrated effective inhibition of biofilm formation and disruption of mature biofilms. Furthermore, LC-AMP-F1 exhibited favorable stability, minimal hemolytic activity, and low toxicity towards different types of eukaryotic cells. Also, it was found that the combination of LC-AMP-F1 with conventional antibiotics exhibited either synergistic or additive therapeutic benefits. Concerning the antibacterial mechanism, scanning electron microscopy and SYTOX Green staining results showed that LC-AMP-F1 increased cell membrane permeability and swiftly disrupted bacterial cell membranes to exert its antibacterial effects. In summary, the findings and studies facilitated the development and clinical application of novel antimicrobial agents.

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Local Oral Delivery Agents with Anti-Biofilm Properties for the Treatment of Periodontitis and Peri-Implantitis. A Narrative Review

Cited by 10 publications

References 109 publications

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

LC-AMP-F1 Derived from the Venom of the Wolf Spider Lycosa coelestis, Exhibits Antimicrobial and Antibiofilm Activities

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