In general, Multi‐User Multiple Input Multiple Output Orthogonal Frequency Division Multiplexing (MU‐MIMO‐OFDM) enables multiple users to simultaneously communicate with a single base station using multiple antennas and OFDM modulation. Nevertheless, resource allocation challenges such as power management and delay optimization arise within MU‐MIMO‐OFDM systems, requiring sophisticated solutions to ensure efficient use of resources and optimal system performance. Thus, joint power and delay optimization‐based resource allocation using a Deep Convolutional Pyramid‐Dilated Neural Network (DCPDNN) with Red piranha optimization and Optimal Delay Scheduling conflict graphs Algorithm (DCPDNN‐RPO‐ODSCGA) in MU‐MIMO‐OFDM system is proposed in this presented research. The proposed mechanism is performed in two stages: power allocation and delay optimization. In the first stage, through a Deep Convolutional Pyramid‐Dilated Neural Network (DCPDNN), which aims to maximize throughput, the network resources are distributed to user equipment (UEs) based on power and transmission rate. To reduce the loss function, Red Piranha Optimization (RPO) is proposed to optimize the layers of DCPDNN. In the second stage, the Optimal Delay Scheduling conflict graphs Algorithm (ODSCGA) is proposed for the optimizing delay in the MU‐MIMO‐OFDM system. The multiracial envelope procedure and service curve for traffic flows in the uplink transmission are used in the ODSCGA approach to estimate the delay‐bound value. Ideas like the maximal weight independent set and optimal conflict graph are also utilized. The simulations of DCPDNN‐RPO‐ODSCGA were conducted using MATLAB software. Thus, the proposed approach has attained higher spectral capacity, higher fairness index, and increased cumulative distribution function (CDF), 29.74%, 32.98%, and 16.46% lower loss rate, 28.05%, 24.09%, and 17.45% improved energy efficiency, 15.09%, 13.78%, and 12.05% lower processing time than other conventional approaches like MPQM‐SCA, Hyb‐BF‐DSA, and SIA‐FDBD methods, respectively.