Local radiofrequency-induced hyperthermia using CuNi nanoparticles with therapeutically suitable Curie temperature

Kuznetsov, Anatoly A.; Leontiev, Vladimir; Brukvin, Vladimir A.; Vorozhtsov, Georgy N.; Kogan, Boris; Shlyakhtin, O.A.; Yunin, Alexander M.; Tsybin, O. I.; Кузнецов, О. А.

doi:10.1016/j.jmmm.2006.11.199

Cited by 61 publications

(41 citation statements)

References 8 publications

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“…Figure is reprinted from (96) with permission from Elsevier. with imaging techniques, developing materials with a limiting Curie temperature as a safety measure for use in vivo, or a combination of these goals (13,18,77,82). For instance, Lao and Ramanujan studied the effect of magnetic field strength on heating in hydrogel-magnetite composite materials (116).…”

Section: Current Research On Magnetothermally-triggered Systemsmentioning

confidence: 99%

Magnetothermally-responsive Nanomaterials: Combining Magnetic Nanostructures and Thermally-Sensitive Polymers for Triggered Drug Release

2008

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This paper reviews the design and development of magnetothermally-triggered drug delivery systems, whereby magnetic nanoparticles are combined with thermally-activated materials. By combining superparamagnetic nanoparticles with lower critical solution temperature (LCST) polymers, an alternating current (AC) magnetic field can be used to trigger localized heating in vivo, which in turn causes a phase change in the host polymer to allow diffusion and release of drugs. The use of magnetic nanoparticles for biomedical applications is reviewed, as well as the design of thermally-activated polymeric systems. Current research on externally-triggered delivery is highlighted, with a focus on the design and challenges in developing magnetothermally-activated systems.

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Section: Current Research On Magnetothermally-triggered Systemsmentioning

confidence: 99%

Magnetothermally-responsive Nanomaterials: Combining Magnetic Nanostructures and Thermally-Sensitive Polymers for Triggered Drug Release

2008

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“…CuNi alloys containing about 40wt.% Ni possess a low temperature coefficient of resistivity [1] and they are commonly used for resistive applications [2]. Literature perusal reveals diverse physical and chemical methods of synthesis, such as plasmachemical re-condensation [3], mechanical milling [4,5], diol-and polyol reduction methods [6,7], hydrothermal reduction [8][9][10], sol-gel process [11,12], electrochemical methods [13][14][15][16], metal atom-solvent co-condensation [17], microemulsion technique [18][19][20], reduction of precipitated copper and nickel compounds [21,22], combustion reactions [23,24], etc. for the preparation of CuNi bimetallic and alloy nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Composition-dependent sintering behaviour of chemically synthesised CuNi nanoparticles and their application in aerosol printing for preparation of conductive microstructures

et al. 2012

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Copper, nickel and copper-nickel nanoparticles were prepared by solution combustion method for use in direct write printing. Structural (X-ray diffraction) and morphological (transmission electron microscope) investigations showed that pure metal (Cu and Ni) and CuNi alloy particles with face-centred cubic crystal structure were formed. Atomic absorption spectrometer studies confirmed that the nanoparticle compositions corresponded to the initial Cu/Ni molar ratios selected for synthesis. Particle size and morphology were significantly influenced by composition, with high Cu content coinciding with small, spherical particles as opposed to larger, irregular shapes observed at high Ni concentrations. X-ray photoelectron spectroscopy measurements revealed that after the reduction process the surface of the alloy nanoparticles was partially oxidised in air and the amount of metallic surface species decreased, while the concentration of oxidic surface species and hydroxides increased with increasing Cu concentration (i.e. decreasing particle size). Dispersions of CuNi nanoparticles have been deposited by use of AerosolJet® and sintered under reducing atmosphere at 300-800 °C in order to prepare conductive structures. Resistivity measurements and microscopical studies (SEM-FIB) of printed and sintered CuNi structures showed that the sintering properties of nanoparticles were dependent on their chemical composition

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“…The particle size still enables direct injection; however, it cannot be targeted to the tumor by cellular carriers. Copper-nickel NPs (,100 nm) with T c =40°C-60°C were tested by Kuznetsov et al 23 They proved that the tissue may be heated by the deposited NPs, nevertheless long-term biocompatibility of the particles is questionable due to missing coating. The silica layer, which we used as a NP coating, should be thick enough to prevent direct contact of the core with the environment in vivo and may ensure safeness of the material.…”

Section: Histologymentioning

confidence: 99%

Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation

Herynek

Turnovcová

Veverka

et al. 2016

IJN

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Introduction Magnetic nanoparticles (NPs) represent a tool for use in magnetic resonance imaging (MRI)-guided thermoablation of tumors using an external high-frequency (HF) magnetic field. To avoid local overheating, perovskite NPs with a lower Curie temperature ( T c ) were proposed for use in thermotherapy. However, deposited power decreases when approaching the Curie temperature and consequently may not be sufficient for effective ablation. The goal of the study was to test this hypothesis. Methods Perovskite NPs ( T c =66°C–74°C) were characterized and tested both in vitro and in vivo. In vitro, the cells suspended with NPs were exposed to a HF magnetic field together with control samples. In vivo, a NP suspension was injected into a induced tumor in rats. Distribution was checked by MRI and the rats were exposed to a HF field together with control animals. Apoptosis in the tissue was evaluated. Results and discussion In vitro, the high concentration of suspended NPs caused an increase of the temperature in the cell sample, leading to cell death. In vivo, MRI confirmed distribution of the NPs in the tumor. The temperature in the tumor with injected NPs did not increase substantially in comparison with animals without particles during HF exposure. We proved that the deposited power from the NPs is too small and that thermoregulation of the animal is sufficient to conduct the heat away. Histology did not detect substantially higher apoptosis in NP-treated animals after ablation. Conclusion Magnetic particles with low T c can be tracked in vivo by MRI and heated by a HF field. The particles are capable of inducing cell apoptosis in suspensions in vitro at high concentrations only. However, their effect in the case of extracellular deposition in vivo is questionable due to low deposited power and active thermoregulation of the tissue.

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Local radiofrequency-induced hyperthermia using CuNi nanoparticles with therapeutically suitable Curie temperature

Cited by 61 publications

References 8 publications

Magnetothermally-responsive Nanomaterials: Combining Magnetic Nanostructures and Thermally-Sensitive Polymers for Triggered Drug Release

Magnetothermally-responsive Nanomaterials: Combining Magnetic Nanostructures and Thermally-Sensitive Polymers for Triggered Drug Release

Composition-dependent sintering behaviour of chemically synthesised CuNi nanoparticles and their application in aerosol printing for preparation of conductive microstructures

Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation

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